Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100083
Funder
Australian Research Council
Funding Amount
$777,493.00
Summary
A cutting-edge and high-throughput nuclear magnetic resonance platform. The proposal aims to establish a multi-institutional nuclear magnetic resonance (NMR) platform across two of Victoria’s leading research universities. The platform will consist of two state-of-the-art NMR spectrometers equipped with parallel acquisition and variable temperature capabilities. It will renew obsolete equipment and support cutting-edge research in fundamental and applied chemical and materials science across the ....A cutting-edge and high-throughput nuclear magnetic resonance platform. The proposal aims to establish a multi-institutional nuclear magnetic resonance (NMR) platform across two of Victoria’s leading research universities. The platform will consist of two state-of-the-art NMR spectrometers equipped with parallel acquisition and variable temperature capabilities. It will renew obsolete equipment and support cutting-edge research in fundamental and applied chemical and materials science across the Victorian region. Expected outcomes include enhanced research capacity and productivity, supporting new interdisciplinary collaborations. Benefits will accrue across the spectrum of the chemical sciences and include environmental monitoring, drug development, process chemistry, and advanced materials manufacturing.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100065
Funder
Australian Research Council
Funding Amount
$423,808.00
Summary
Designing Organocatalysts to Achieve Hyperpolarised Magnetic Resonance. Magnetic resonance techniques (such as MRI scans) suffer from an inherent insensitivity problem. In medical imaging, this can hamper diagnosis and mean long scan times for patients. This project aims to chemically develop catalysts which dramatically increase sensitivity, producing a signal that is thousands of times more visible. This project is significant as these catalysts can turn common, harmless molecules in the body ....Designing Organocatalysts to Achieve Hyperpolarised Magnetic Resonance. Magnetic resonance techniques (such as MRI scans) suffer from an inherent insensitivity problem. In medical imaging, this can hamper diagnosis and mean long scan times for patients. This project aims to chemically develop catalysts which dramatically increase sensitivity, producing a signal that is thousands of times more visible. This project is significant as these catalysts can turn common, harmless molecules in the body - even water - into visible tracers. The expected outcomes of this project include the synthesis and understanding of these catalysts which will be chemically fine-tuned to maximise their effectiveness. Potential benefits include translation to MRI applications to improve diagnosis and treatment, or chemical monitoring.Read moreRead less
New laser and mass spectrometry methods for detecting protonation isomers. Mass spectrometry is a major tool for the detection of molecules for understanding disease, pollution control and chemical synthesis. However, intricate differences in molecular structure - vital to chemical function - can confuse detection methods leading to false negatives. This is especially problematic for complex biological samples. Recent breakthroughs in laser-based mass spectrometry methods, combined with ion mobi ....New laser and mass spectrometry methods for detecting protonation isomers. Mass spectrometry is a major tool for the detection of molecules for understanding disease, pollution control and chemical synthesis. However, intricate differences in molecular structure - vital to chemical function - can confuse detection methods leading to false negatives. This is especially problematic for complex biological samples. Recent breakthroughs in laser-based mass spectrometry methods, combined with ion mobility, now allow detection of subtle yet important structural features. This project aims to exploit these advances by developing new instrumentation and protocols with these enhanced capabilities thus accelerating advances in automated mass spectrometry, improved antibiotic detection and complex biomolecule screening.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100060
Funder
Australian Research Council
Funding Amount
$563,390.00
Summary
Shared picosecond-laser facility. This project aims to extend the Shared Picosecond Laser Facility to include picosecond-pulse technology and to incorporate new consortium members. The Facility, shared among members at four universities and building on over 23 years of collaboration, continues to provide access to state-of-the-art lasers. The Facility will take advantage of its bulk purchasing power to negotiate significant discounts, extended warranties and maintenance contracts. The new lasers ....Shared picosecond-laser facility. This project aims to extend the Shared Picosecond Laser Facility to include picosecond-pulse technology and to incorporate new consortium members. The Facility, shared among members at four universities and building on over 23 years of collaboration, continues to provide access to state-of-the-art lasers. The Facility will take advantage of its bulk purchasing power to negotiate significant discounts, extended warranties and maintenance contracts. The new lasers will enable access to picosecond timescales and facilitate complex multi-laser experiments in a wide variety of projects including reaction dynamics, materials chemistry and photovoltaics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100057
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A diffractometer for small molecule structural elucidation by crystallographic analysis. X-ray diffractometry provides an unambiguous means of identifying the three-dimensional spatial arrangement of atoms within molecules affording important insights into the origins of chemical properties. A modern diffractometer will provide information to help develop new functional materials, therapeutic agents and environmentally sustainable processes.
Discovery Early Career Researcher Award - Grant ID: DE200100549
Funder
Australian Research Council
Funding Amount
$384,616.00
Summary
The true impact of fluorinated compounds in the atmosphere. This project aims to improve the underpinning science that is incorporated into atmospheric chemistry models so humanity can better understand, predict and respond to the impact of emitting large volumes of fluorinated compounds. This project expects to challenge assumptions currently used to model the atmospheric chemistry of organic fluorine compounds, as well as to evaluate the environmental impact of replacements. Expected outcomes ....The true impact of fluorinated compounds in the atmosphere. This project aims to improve the underpinning science that is incorporated into atmospheric chemistry models so humanity can better understand, predict and respond to the impact of emitting large volumes of fluorinated compounds. This project expects to challenge assumptions currently used to model the atmospheric chemistry of organic fluorine compounds, as well as to evaluate the environmental impact of replacements. Expected outcomes include a general model of organic fluorine photochemistry and refined atmospheric chemistry models. This should provide significant benefits in that humanity can avoid an environmental disaster and new, environmentally benign products can be developed.Read moreRead less
Bespoke rylene diimides for fundamental and applied photophysics. This project aims to develop and apply bespoke fluorescent molecular systems based on rylene diimide. Fluorescence provides a tuneable, exquisitely sensitive readout allowing detailed investigation and application down to the level of single molecules. This project will use fluorescence to study chemical reactions and energy transfer phenomena, design tools and methodologies for microscopy (including emerging super-resolution tech ....Bespoke rylene diimides for fundamental and applied photophysics. This project aims to develop and apply bespoke fluorescent molecular systems based on rylene diimide. Fluorescence provides a tuneable, exquisitely sensitive readout allowing detailed investigation and application down to the level of single molecules. This project will use fluorescence to study chemical reactions and energy transfer phenomena, design tools and methodologies for microscopy (including emerging super-resolution techniques), and develop 'designed for purpose' systems for a range of applications. The knowledge gained and proofs-of-principle established are expected to influence fields as diverse as energy storage and transduction, imaging and diagnostics and chemical reactions and catalysis.Read moreRead less
Artificial photosynthesis: developing a simple, functional light harvesting porphyrin-protein ensemble. Inspired by photosynthesis, in this project we will fabricate a light driven reaction centre using an array of artificial chlorophylls or porphyrins integrated into a synthetic protein. This centre has the potential to be used as a photocatalyst to, for example, split water into hydrogen and oxygen or be the active component of a solar cell.
Spectroscopic investigations into nano-scale drug interactions and molecular processes in single living cells and isolated molecules. This project will develop micro-spectroscopy and nano-spectroscopy molecular imaging based techniques to spatially locate and determine the bonding sites of a new range of chemotherapeutic drugs designed to treat cancer and malaria. This project will adopt a translational approach looking first at drug interactions directly with molecules such as DNA. Secondly, in ....Spectroscopic investigations into nano-scale drug interactions and molecular processes in single living cells and isolated molecules. This project will develop micro-spectroscopy and nano-spectroscopy molecular imaging based techniques to spatially locate and determine the bonding sites of a new range of chemotherapeutic drugs designed to treat cancer and malaria. This project will adopt a translational approach looking first at drug interactions directly with molecules such as DNA. Secondly, investigating these interactions in living cells and finally applying the technology to tissue samples. The outcome of this research will be new drug screening technologies and methodologies to address two of the most devastating diseases to afflict human kind, offering hope to the countless millions suffering from these diseases.Read moreRead less