Multi-scale Process Modelling for Intelligent Control. Processing and manufacturing systems are inherently multi-scale in their behaviour. From the molecular scale to the enterprise-wide scale. This and other attributes of the individual models create difficulties in the design and control of such systems. This project will develop suitable multi-scale measures (metrics) for process models based on an object oriented assumption based modelling language. It will lead to enhanced intelligent contr ....Multi-scale Process Modelling for Intelligent Control. Processing and manufacturing systems are inherently multi-scale in their behaviour. From the molecular scale to the enterprise-wide scale. This and other attributes of the individual models create difficulties in the design and control of such systems. This project will develop suitable multi-scale measures (metrics) for process models based on an object oriented assumption based modelling language. It will lead to enhanced intelligent control strategies and improved operational performance through use of the most appropriate model. The work will focus on industrially important reaction and particulate processing systemsRead moreRead less
Multi-Scale, Multi-Form Approach to the Modelling, Design and Control of Complex Particulate Processes. Many particulate processes suffer from high recycle rates and instability due to lack of knowledge at various scale levels, and on the fitness between model forms and applications. This project will develop a complete model hierarchy ranging from the microscopic scale to full plant scale using a multi-scale, multi-form approach. The joint force of two world class teams will tackle the complex ....Multi-Scale, Multi-Form Approach to the Modelling, Design and Control of Complex Particulate Processes. Many particulate processes suffer from high recycle rates and instability due to lack of knowledge at various scale levels, and on the fitness between model forms and applications. This project will develop a complete model hierarchy ranging from the microscopic scale to full plant scale using a multi-scale, multi-form approach. The joint force of two world class teams will tackle the complex interaction problems covering granulation fundamentals, dynamic modelling, process design and advanced control. The work will lead to significantly improved productivity and quality for a wide range of industrial particulate processes using innovative design and model based control strategies.Read moreRead less
Discrete Element Method for Analysis and Design of Pharmaceutical Encapsulation. Tablets represent the preferred method of dose delivery in the pharmaceutical industry, with over 80% of the market. PressFit - gelcaps have recently been developed, which encase a tablet core within a gelatin coating. The product combines the consumer appeal of capsules with the processing convenience of tablets, and provides a high degree of tamper-resistance. An important issue is that the caplets are required ....Discrete Element Method for Analysis and Design of Pharmaceutical Encapsulation. Tablets represent the preferred method of dose delivery in the pharmaceutical industry, with over 80% of the market. PressFit - gelcaps have recently been developed, which encase a tablet core within a gelatin coating. The product combines the consumer appeal of capsules with the processing convenience of tablets, and provides a high degree of tamper-resistance. An important issue is that the caplets are required to have very precise dimensional precision, an issue not previously of high priority for tabletting . This project seeks to enhance the competitive advantage of this new technology, through a combination of advanced mathematical modeling supported by experiments.Read moreRead less
Scale-up and Intelligent Control of Granulation Processes. Granulation is the process that forms granular products with carefully targeted properties from powdery or liquid feeds. Granular products abound in the pharmaceutical, agricultural & industrial chemicals, and food & consumer goods industries. Poor understanding of the granulation causes delays in the time to market of new products and poor efficiency in large scale continuous granulation plants. This project will build on recent adva ....Scale-up and Intelligent Control of Granulation Processes. Granulation is the process that forms granular products with carefully targeted properties from powdery or liquid feeds. Granular products abound in the pharmaceutical, agricultural & industrial chemicals, and food & consumer goods industries. Poor understanding of the granulation causes delays in the time to market of new products and poor efficiency in large scale continuous granulation plants. This project will build on recent advances in the understanding of granulation fundamentals to (1) develop new robust design and scale up rules (2) develop intelligent control schemes for continuous granulation circuits, and (3) develop a new generation of regime separated granulators. The project is receiving substantial support from 3 industry partners (MSD Australia, Incitec and WMC Fertilizers) with cash contributions over 40% of the ARC grant requested, as well as very substantial in-kind contributions.Read moreRead less
Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microflu ....Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microfluidic platform technology for reproducibly producing targeted polymer nanocarriers having systematically varied properties, a dual-templating method for making targeted silica nanocapsules and new design of in vivo-mimicking 'Tissue Chips' for screening and evaluating the nanocarriers.Read moreRead less
Skid mounted process for on-demand acetylene production. Skid mounted process for on-demand acetylene production. This project aims to develop a new, cheaper, safer and easier process for providing acetylene for the metal fabrication and construction industries. Mains gas (methane) will be converted into acetylene, on-site and on-demand, using a highly compact, transportable skid-based gas generator that is self-operating with a single touch ON-OFF system. This should remove the need to deliver ....Skid mounted process for on-demand acetylene production. Skid mounted process for on-demand acetylene production. This project aims to develop a new, cheaper, safer and easier process for providing acetylene for the metal fabrication and construction industries. Mains gas (methane) will be converted into acetylene, on-site and on-demand, using a highly compact, transportable skid-based gas generator that is self-operating with a single touch ON-OFF system. This should remove the need to deliver bottled acetylene to metal fabrication works, eliminating road transport and storage risks. There is a high potential for export of the plants to countries like China and India that use a calcium carbide-based process as a distributed acetylene source.Read moreRead less
Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will re ....Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will resolve uncertainties in the underlying phenomena. The expected outcome should support future high quality cell cultures suitable for transplantation therapies.Read moreRead less
Plasma-Catalytist Hybrid Process for Simultaneous Removal of NOx and SOx. Coal combustion provides over 80% of the electricity produced in Australia, with the power stations being major emitters of the pollutants NOx and SOx. This project will potentially lead to a new technology to simultaneously remove NOx and SOx in a single and economical process, eliminating the secondary waste streams that disadvantage current competing technologies. This will provide: significant environmental benefits f ....Plasma-Catalytist Hybrid Process for Simultaneous Removal of NOx and SOx. Coal combustion provides over 80% of the electricity produced in Australia, with the power stations being major emitters of the pollutants NOx and SOx. This project will potentially lead to a new technology to simultaneously remove NOx and SOx in a single and economical process, eliminating the secondary waste streams that disadvantage current competing technologies. This will provide: significant environmental benefits for Australia in reducing these dangerous atmospheric pollutants; economic advantage to our power stations by enabling cheaper, more efficient technologies and consolidate Australia's leading position in the world in air pollution control. Read moreRead less
Improving biological nitrogen removal by enhanced mixing in non-aerated bioreactors. Mixing has been identified as a key factor in achieving enhanced performance out of existing and upgraded bioreactors. There is currently a poor understanding of the relationship between non-ideal flow and performance in wastewater treatment bioreactors. The project will determine this relationship and subsequently use it to show how reactor performance can be improved, providing first criteria by which mixing c ....Improving biological nitrogen removal by enhanced mixing in non-aerated bioreactors. Mixing has been identified as a key factor in achieving enhanced performance out of existing and upgraded bioreactors. There is currently a poor understanding of the relationship between non-ideal flow and performance in wastewater treatment bioreactors. The project will determine this relationship and subsequently use it to show how reactor performance can be improved, providing first criteria by which mixing can be assessed, and second a systematic methodology for improving reactor performance by improving mixing.Read moreRead less
Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipi ....Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.Read moreRead less