Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this ....Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this project include a new fundamental understanding of the effect of mechanical properties on cell function, novel insights into the regulation of stem cell fate, and the development of a new class of roughness-tunable materials suitable for use in tissue engineering and pharmaceutical applications. Read moreRead less
Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipi ....Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.Read moreRead less
Single molecule sensing on nanopillars: Reading complex molecular circuits. This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in c ....Single molecule sensing on nanopillars: Reading complex molecular circuits. This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in cellular pathways. Expected outcomes include a universal technology platform to detect single molecules in single cells, with potential to deliver valuable intellectual property of commercial interest and economic benefit through technological advancements.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100357
Funder
Australian Research Council
Funding Amount
$409,118.00
Summary
Catalyst design for converting carbon dioxide into valuable chemicals. This project aims to use solar energy to convert carbon dioxide, the primary greenhouse gas that drives global climate change, into valuable chemicals via catalytic reduction. This project expects to facilitate the selective production of valuable ethylene from carbon dioxide reduction by developing novel cocatalyst materials derived from metal-oxo cluster molecules. Expected outcomes include fundamental understanding of the ....Catalyst design for converting carbon dioxide into valuable chemicals. This project aims to use solar energy to convert carbon dioxide, the primary greenhouse gas that drives global climate change, into valuable chemicals via catalytic reduction. This project expects to facilitate the selective production of valuable ethylene from carbon dioxide reduction by developing novel cocatalyst materials derived from metal-oxo cluster molecules. Expected outcomes include fundamental understanding of the structure-property relationship in new catalytic systems, and technological breakthroughs in reducing carbon dioxide emissions. The success of this project will bring significant environmental and economic benefits, and position Australia at the frontier of global transition to a low-carbon economy.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101190
Funder
Australian Research Council
Funding Amount
$359,446.00
Summary
Interfacial nano-engineering of electrodes for perovskite solar cells. This project aims to explore new strategies of functional electrode design and interfacial engineering for efficient and stable perovskite solar cell application. The key concept is to modify the electron transport and perovskite layers through structural design, interfacial engineering and contact passivation, for use in high-performance solar-to-electricity conversion systems with improved light harvesting and charge collec ....Interfacial nano-engineering of electrodes for perovskite solar cells. This project aims to explore new strategies of functional electrode design and interfacial engineering for efficient and stable perovskite solar cell application. The key concept is to modify the electron transport and perovskite layers through structural design, interfacial engineering and contact passivation, for use in high-performance solar-to-electricity conversion systems with improved light harvesting and charge collection. Expected project outcomes will place Australia at the forefront of practical low-cost and large-scale solar energy conversion technologies.Read moreRead less
Towards Robust Hydrogen Electrode for High-Rate Alkaline Electrolysis. This project aims to develop robust, efficient porous hybrid hydrogen electrodes for electrochemical hydrogen production in anion exchange membrane water electrolyser. anion exchange membrane water electrolyser powered by renewable energy has emerged as a key avenue towards clean hydrogen with zero carbon footprint. However, the electrochemical turnover on the hydrogen electrode has been significantly hindered by the sluggish ....Towards Robust Hydrogen Electrode for High-Rate Alkaline Electrolysis. This project aims to develop robust, efficient porous hybrid hydrogen electrodes for electrochemical hydrogen production in anion exchange membrane water electrolyser. anion exchange membrane water electrolyser powered by renewable energy has emerged as a key avenue towards clean hydrogen with zero carbon footprint. However, the electrochemical turnover on the hydrogen electrode has been significantly hindered by the sluggish reaction kinetics in alkaline solution. The project is expected to generate cost-effective hydrogen electrodes for hydrogen electrolyzers, advanced knowledge in the electrode material engineering, electrochemical reaction mechanistic insights, and eventually promoted development of disruptive electrolysis technology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100930
Funder
Australian Research Council
Funding Amount
$396,948.00
Summary
Defect Engineering Enabling Efficient Solar Hydrogen Production. The project aims to achieve efficient renewable hydrogen production through solar driven photoelectrochemical water splitting. As a carbon-emission free process, photoelectrochemical water splitting is significant in solar hydrogen supply. The key idea is to design innovative photoelectrode materials using defect engineering strategy which allows more efficient conversion of solar energy to hydrogen. The expected outcomes include h ....Defect Engineering Enabling Efficient Solar Hydrogen Production. The project aims to achieve efficient renewable hydrogen production through solar driven photoelectrochemical water splitting. As a carbon-emission free process, photoelectrochemical water splitting is significant in solar hydrogen supply. The key idea is to design innovative photoelectrode materials using defect engineering strategy which allows more efficient conversion of solar energy to hydrogen. The expected outcomes include high Solar-to-Hydrogen conversion efficiency on the new materials and cutting-edge knowledge in advanced material design. The success of this project will contribute to the implementation of the Australia's National Hydrogen Strategy and position the nation at the frontier of renewable hydrogen supply technologies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101577
Funder
Australian Research Council
Funding Amount
$446,639.00
Summary
Two-Dimensional Covalent Organic Framework for Next-Generation Batteries. This project aims to develop advanced two-dimensional (2D) covalent organic framework (COF) materials for sodium and potassium-ion batteries. It expects to generate a new family of few-layered 2D COF materials and their 2D-2D heterostructured composites with improved electrochemical properties, and develop processing technologies and fundamental understanding of COF-based electrodes for flexible sodium and potassium-ion ba ....Two-Dimensional Covalent Organic Framework for Next-Generation Batteries. This project aims to develop advanced two-dimensional (2D) covalent organic framework (COF) materials for sodium and potassium-ion batteries. It expects to generate a new family of few-layered 2D COF materials and their 2D-2D heterostructured composites with improved electrochemical properties, and develop processing technologies and fundamental understanding of COF-based electrodes for flexible sodium and potassium-ion batteries. Expected outcomes include novel materials, technologies, and energy-storage options for Australia. Significant economic and environmental benefits are expected from developing advanced sodium and potassium-ion batteries with low cost, high energy density, and improved safety for renewable energy storage.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH210100040
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this ....ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this Hub include advanced manufacturing capacity for connected sensors, strategic partnerships and commercialisation skills to translate sensors research to create economic benefits such as jobs and locally-made products for domestic and export markets, as well as improving the health of Australians.Read moreRead less
Designer Nanoparticles Enable mRNA Protein Factories. Intracellular delivery of mRNA facilitates target protein production, which could build protein factories that are essential in biomanufacturing industries. However, the instability of mRNA greatly lowers the protein production performance, limiting the commercial translation potential. This project aims to develop a new generation of nanoparticle delivery system to enhance mRNA stability against intracellular unstable cue, enzymatic digestio ....Designer Nanoparticles Enable mRNA Protein Factories. Intracellular delivery of mRNA facilitates target protein production, which could build protein factories that are essential in biomanufacturing industries. However, the instability of mRNA greatly lowers the protein production performance, limiting the commercial translation potential. This project aims to develop a new generation of nanoparticle delivery system to enhance mRNA stability against intracellular unstable cue, enzymatic digestion and thermal stress. This will be achieved by tailoring the nanochemistry at multi-scales. Expected outcomes include new knowledge in custom-design of functional nanomaterials for mRNA delivery, and new technology that will bring commercial benefits to the partner organisation and the biopharma sector.Read moreRead less