Energetics and dynamics of solvated biologically relevant molecules using liquid microjet and ion imaging technologies. The shape of many biomolecules in solution plays a critical role in determining their biological activity and function. It is known that the bonds that form between the biomolecules and the water solvent control this shape. However, very little is known about the strength and structure of these bonds at different sites around the biomolecule. Many experiments have informed u ....Energetics and dynamics of solvated biologically relevant molecules using liquid microjet and ion imaging technologies. The shape of many biomolecules in solution plays a critical role in determining their biological activity and function. It is known that the bonds that form between the biomolecules and the water solvent control this shape. However, very little is known about the strength and structure of these bonds at different sites around the biomolecule. Many experiments have informed us about the strength of the bonds, others have told us where the bonds occur. This project will provide both pieces of information for the first time, allowing us to better understand, and therefore control, biological function. This work will assist in the development of new biotechnology processes, especially in the emerging area of proteomics.Read moreRead less
Hydrodynamics of Bubble Column Reactors. This project will study the hydrodynamics of bubble columns with the aim of optimising these reactors for offshore gas-to-liquid plants. Along with experiments using the state-of-art techniques such as the particle image velocimetry, radioactive particle tracking, electrical capacitance tomography and optical probes, computational fluid dynamics simulations will be conducted to gain a deeper insight into bubble-induced turbulence and regime transitions in ....Hydrodynamics of Bubble Column Reactors. This project will study the hydrodynamics of bubble columns with the aim of optimising these reactors for offshore gas-to-liquid plants. Along with experiments using the state-of-art techniques such as the particle image velocimetry, radioactive particle tracking, electrical capacitance tomography and optical probes, computational fluid dynamics simulations will be conducted to gain a deeper insight into bubble-induced turbulence and regime transitions in these reactors. This information will then be used to devise scale-up strategies of these complex and industrially important equipment.Read moreRead less
Influence of adsorbed surfactants on three phase contact line motion at high capillary number. The interaction between thin films and solid surfaces underpins the performance of a number of value-adding industrial processes, most notably metallurgical coating operations. Typically, these operations are performed at speeds well beyond the range of existing models, thereby limiting their value when changes in operation occur or when there are problems with product quality. Existing models are also ....Influence of adsorbed surfactants on three phase contact line motion at high capillary number. The interaction between thin films and solid surfaces underpins the performance of a number of value-adding industrial processes, most notably metallurgical coating operations. Typically, these operations are performed at speeds well beyond the range of existing models, thereby limiting their value when changes in operation occur or when there are problems with product quality. Existing models are also limited by their inability to account for the presence of surfactants commonly used throughout industry. This study will produce a capability for predicting how velocity and local changes in molecular composition affect the wetting/dewetting of coated surfaces.Read moreRead less
Confinement of space based on association of water soluble container molecules. The proposed research addresses the use of water soluble bowl shaped molecules or ions (cavitands) in conjunction with metal ions and crown ether and related cryptand molecules to form molecular capsules, two or more of the components being pre-programmed to assemble thus. The new materials will be unique in supramolecular chemistry, with the associated architectures bearing on materials science, molecular electronic ....Confinement of space based on association of water soluble container molecules. The proposed research addresses the use of water soluble bowl shaped molecules or ions (cavitands) in conjunction with metal ions and crown ether and related cryptand molecules to form molecular capsules, two or more of the components being pre-programmed to assemble thus. The new materials will be unique in supramolecular chemistry, with the associated architectures bearing on materials science, molecular electronics, separation sciences, and drug delivery. The new range of water soluble container molecules that will become accessible as part of this proposal, promises new applications in these areas.Read moreRead less
Design and synthesis of novel lanthanoid complexes for the fabrication of light emitting devices. There is a huge and still growing economy centred around the design and fabrication of low-cost Light Emitting Devices (LEDs), as demonstrated by the excess of US$1.3 billion invested in this field between 2000 and 2007. Nations focused on the production of new and more efficient materials will be at the forefront of these emerging technologies. The major thrust of this proposal, the design and prep ....Design and synthesis of novel lanthanoid complexes for the fabrication of light emitting devices. There is a huge and still growing economy centred around the design and fabrication of low-cost Light Emitting Devices (LEDs), as demonstrated by the excess of US$1.3 billion invested in this field between 2000 and 2007. Nations focused on the production of new and more efficient materials will be at the forefront of these emerging technologies. The major thrust of this proposal, the design and preparation of luminescent rare earths complexes, and their use for the fabrication of LEDS, represent a good opportunity for Australia to access this growing market. Read moreRead less
Cyclophane Carbene Complexes as Catalysts: An Integrated Synthetic, Structural, and Mechanistic Approach. Metal-carbene complexes are emerging as efficient catalysts for chemical processes of immense importance to the pharmaceutical and fine chemicals industries. This project will build on the recent discovery of a family of complexes that exhibits the highest activity yet reported for metal-carbene catalysts in carbon-carbon bond-forming reactions. Insights into the ways the new catalysts work ....Cyclophane Carbene Complexes as Catalysts: An Integrated Synthetic, Structural, and Mechanistic Approach. Metal-carbene complexes are emerging as efficient catalysts for chemical processes of immense importance to the pharmaceutical and fine chemicals industries. This project will build on the recent discovery of a family of complexes that exhibits the highest activity yet reported for metal-carbene catalysts in carbon-carbon bond-forming reactions. Insights into the ways the new catalysts work will be gained through a combination of synthetic, mechanistic, and structural studies. This detailed investigation of structure/reactivity relationships will provide an understanding of why these catalyst are so efficient and hence give synthetic leads for the development of superior new catalysts suitable for industrial application.Read moreRead less
Biochar as a renewable catalyst for hot gas cleaning. This project aims to generate new knowledge for the development of a novel hot gas cleaning technology. This project expects to understand the mechanisms of tar reforming using biochar as a renewable catalyst, which can avoid the problems associated with the catalyst deactivation and catalyst disposal if conventional supported catalysts are used. Expected outcomes of this project include a theoretical framework and a kinetic model describing ....Biochar as a renewable catalyst for hot gas cleaning. This project aims to generate new knowledge for the development of a novel hot gas cleaning technology. This project expects to understand the mechanisms of tar reforming using biochar as a renewable catalyst, which can avoid the problems associated with the catalyst deactivation and catalyst disposal if conventional supported catalysts are used. Expected outcomes of this project include a theoretical framework and a kinetic model describing the catalytic reforming of tar as part of the hot gas cleaning during the conversion of biomass. The technology will contribute to Australia’s improved energy security and reduced carbon dioxide (CO2) emissions in the carbon-constrained future.Read moreRead less
A New Spin on Liquid Hydrogen: Controlled Cold Energy. While hydrogen is set to play a leading role in global decarbonisation, significant challenges remain regarding methods for its reliable storage and transportation. Hydrogen liquefaction has emerged as a promising approach in this regard due to its high energy density and hydrogen purity, but is currently prohibitively expensive. In this project we will exploit the peculiar spin physics of hydrogen to alleviate liquefactions costs through t ....A New Spin on Liquid Hydrogen: Controlled Cold Energy. While hydrogen is set to play a leading role in global decarbonisation, significant challenges remain regarding methods for its reliable storage and transportation. Hydrogen liquefaction has emerged as a promising approach in this regard due to its high energy density and hydrogen purity, but is currently prohibitively expensive. In this project we will exploit the peculiar spin physics of hydrogen to alleviate liquefactions costs through the provision of controllable refrigeration (so-called 'cold energy') following regasification. In particular we will measure, optimise and exploit the highly endothermic catalysed conversion of para- to ortho- hydrogen, which can provide up to 525 kJ/kg of cooling at convenient temperatures. Read moreRead less
Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lip ....Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lipid biology at the cellular and sub-cellular level across a wide range of in vitro and in vivo models. The outcomes of this project should provide significant knowledge to tackle modern societal challenges in healthy ageing, brain pathologies and neurodegenerative diseases.Read moreRead less
Illuminating Molecular Electronic Rectification. This project aims to develop molecular rectifiers incorporating organometallic complexes for future electronics applications. The organometallic molecules will be an integral part of the electronic device to ameliorate the technological problems arising from miniaturisation of semiconductors. Expected outcomes are a new approach to molecular designs that provide a rectifying response in single molecules and large area molecular junctions. This sho ....Illuminating Molecular Electronic Rectification. This project aims to develop molecular rectifiers incorporating organometallic complexes for future electronics applications. The organometallic molecules will be an integral part of the electronic device to ameliorate the technological problems arising from miniaturisation of semiconductors. Expected outcomes are a new approach to molecular designs that provide a rectifying response in single molecules and large area molecular junctions. This should build manufacturing capacity in Australia and enhance international collaboration and reputation by addressing significant challenges in molecular electronics. Benefits arising include skilled researchers, internationalisation of Australian research and contributions to fundamental science.Read moreRead less