Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882889
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
History, the archives and new technologies: developing the Australian women's archives project. This project will create and define generic tools and services to increase the productivity of those involved with the creation, maintenance and use of source material for humanities research. It will provide a pathway to move this infrastructure onto a more sustainable footing and address issues of information overload, authority and quality facing researchers in the networked digital age. This imper ....History, the archives and new technologies: developing the Australian women's archives project. This project will create and define generic tools and services to increase the productivity of those involved with the creation, maintenance and use of source material for humanities research. It will provide a pathway to move this infrastructure onto a more sustainable footing and address issues of information overload, authority and quality facing researchers in the networked digital age. This imperative is seen by scholars and representatives of the nation's major collecting institutions as a primary limiting factor in the contemporary research environment. The project will enhance Australia's reputation as a world leader in the development of web-based information infrastructure to support research and scholarship.Read moreRead less
Chemical building block size principles for discovery chemists. This project aims to deliver an innovative platform of new fundamental molecules, and associated design principles that will assist discovery chemists (DCs) to sidestep outdated, caged hydrocarbon chemical building blocks (CHCBBs). The expanding global population places significant challenges on discovery chemistry, driven by an appetite for innovative chemical technologies for societal longevity such as pharmaceuticals, agrichemica ....Chemical building block size principles for discovery chemists. This project aims to deliver an innovative platform of new fundamental molecules, and associated design principles that will assist discovery chemists (DCs) to sidestep outdated, caged hydrocarbon chemical building blocks (CHCBBs). The expanding global population places significant challenges on discovery chemistry, driven by an appetite for innovative chemical technologies for societal longevity such as pharmaceuticals, agrichemicals, and microelectronics. In translating this new CHCBB technology into accessible commodity supply streams, the project hopes to provide DCs with tools to sustain chemical technology evolution in a multitude of key industries that underpin the longevity of society.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989127
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
A High-Throughput Neutron Spectrometer for The Study of Atomic and Molecular Motion at ANSTO. Neutron scattering enables new science across a broad range of disciplines, and for this reason it is undergoing major expansion in the USA, Europe, Japan and Australia. Various diffactometers and spectrometers have recently been built at ANSTO, but an instrumental option for a high-throughput cross-discipline spectroscopy is urgently needed. Fortunately, it is fairly straightforward to add this type of ....A High-Throughput Neutron Spectrometer for The Study of Atomic and Molecular Motion at ANSTO. Neutron scattering enables new science across a broad range of disciplines, and for this reason it is undergoing major expansion in the USA, Europe, Japan and Australia. Various diffactometers and spectrometers have recently been built at ANSTO, but an instrumental option for a high-throughput cross-discipline spectroscopy is urgently needed. Fortunately, it is fairly straightforward to add this type of option to an existing spectrometer that will broaden its user-base from specialised applications in physics to more general applications in physics, chemistry, materials-science and biology. This additional option provides a totally new way for Australian scientists to study atomic and molecular motions. Read moreRead less
Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would p ....Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would play an important role in preventing avian influenza outbreaks, which are currently affecting both developed and developing countries, costing millions of dollars due to the death and culling of infected poultry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989608
Funder
Australian Research Council
Funding Amount
$190,000.00
Summary
The Heron Island Climate Change Observatory: An In-Situ Ocean Acidification and Carbonate Chemistry Monitoring Platform. Climate change and ocean acidification are widely recognized as key threats to Australia's natural ecosystems, yet we are currently ill-equipped to respond due to poor knowledge of the scale/nature of the impacts. The Heron Island Climate Change Observatory will establish key infrastructure that will rapidly improve our understanding of the impacts of ocean acidification whic ....The Heron Island Climate Change Observatory: An In-Situ Ocean Acidification and Carbonate Chemistry Monitoring Platform. Climate change and ocean acidification are widely recognized as key threats to Australia's natural ecosystems, yet we are currently ill-equipped to respond due to poor knowledge of the scale/nature of the impacts. The Heron Island Climate Change Observatory will establish key infrastructure that will rapidly improve our understanding of the impacts of ocean acidification which is important to local communities and the nation given that coral reefs support over $6 billion in revenue (and employ 60,000 people) each year. This critically important information is essential to the management and protection of Australia's coral reefs, including the Great Barrier Reef.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100148
Funder
Australian Research Council
Funding Amount
$1,350,000.00
Summary
Advanced Nuclear Magnetic Resonance Technologies for Southeast Queensland. This project aims to establish an advanced Nuclear Magnetic Resonance capability and capacity at two of Queenslands' leading research intensive universities. The project expects to enhance the scope and productivity of hundreds of research projects spanning natural products, synthetic, medicinal, materials and environmental science. Expected outcomes include smarter science, more productive collaborations and superior res ....Advanced Nuclear Magnetic Resonance Technologies for Southeast Queensland. This project aims to establish an advanced Nuclear Magnetic Resonance capability and capacity at two of Queenslands' leading research intensive universities. The project expects to enhance the scope and productivity of hundreds of research projects spanning natural products, synthetic, medicinal, materials and environmental science. Expected outcomes include smarter science, more productive collaborations and superior research training, leading to innovative solutions to challenging problems that confront science and society. This investment should provide significant benefits in the form of new knowledge across multiple disciplines, informing the design of future medicines, agrochemicals, materials and other products.
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Eradicating bacterial biofilms with nitroxide-antimicrobial hybrids. This project aims to develop new antimicrobials to address the rise of drug-resistant infections and resilient bacterial communities called biofilms. We aim to break new ground in our fundamental knowledge of antimicrobial mechanisms and exploit this understanding by fusing cellular/molecular microbiology and synthetic chemistry approaches. We seek to gain an in-depth understanding of how nitroxides induce bacterial biofilm dis ....Eradicating bacterial biofilms with nitroxide-antimicrobial hybrids. This project aims to develop new antimicrobials to address the rise of drug-resistant infections and resilient bacterial communities called biofilms. We aim to break new ground in our fundamental knowledge of antimicrobial mechanisms and exploit this understanding by fusing cellular/molecular microbiology and synthetic chemistry approaches. We seek to gain an in-depth understanding of how nitroxides induce bacterial biofilm dispersal, which is critical for the discovery of anti-biofilm molecules that do not fail due to resistance development. These breakthroughs should induce a step-change in our ability to reduce the occurrence of biofilm-related infection in fields ranging from medical and veterinary to biotechnology and agriculture.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883096
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Analytical and Preparative Enantioselective Chromatography. Enantiomers are forms of the same molecule that are non-superimposable mirror images of one another, like a left hand and a right hand. Because they are so similar they are very difficult to separate. However, they have very different biological properties, such as when used as drugs. One enantiomer may be beneficial while the other has no effect or sometimes is even toxic. Therefore it is important to be able to tell how much of ea ....Analytical and Preparative Enantioselective Chromatography. Enantiomers are forms of the same molecule that are non-superimposable mirror images of one another, like a left hand and a right hand. Because they are so similar they are very difficult to separate. However, they have very different biological properties, such as when used as drugs. One enantiomer may be beneficial while the other has no effect or sometimes is even toxic. Therefore it is important to be able to tell how much of each enantiomer is present in a sample and to be able to separate them. This facility will allow us to do both of these things.Read moreRead less
Nitroxide-containing scaffolds for controlling biofilm-related infections. Bacterial biofilms are a major problem in healthcare systems around the world as they cause persistent and chronic infections, including those associated with medical implants and cystic fibrosis. This project aims to develop new chemical approaches to deliver nitroxides at surface interfaces and in microparticles to facilitate long term control over biofilm growth. It is expected that these functionalised scaffolds will ....Nitroxide-containing scaffolds for controlling biofilm-related infections. Bacterial biofilms are a major problem in healthcare systems around the world as they cause persistent and chronic infections, including those associated with medical implants and cystic fibrosis. This project aims to develop new chemical approaches to deliver nitroxides at surface interfaces and in microparticles to facilitate long term control over biofilm growth. It is expected that these functionalised scaffolds will represent a breakthrough in the field and will have a profound impact by reducing infection rates associated with medical devices and improving airway clearance in cystic fibrosis patients.Read moreRead less
Bubble, Bubble CO2 is the trouble: A Natural Ocean Acidification Experiment in a coral reef setting. Carbon dioxide seep sites expose shallow coral reefs in Papua New Guinea to volcanic carbon dioxide resulting in gradients of seawater ranging from pH 8.0 (normal) to a more acidic pH of 7.5. Some areas of these reefs experience carbon dioxide exposure equivalent to IPCC predictions for 2050 and 2100. This project will reconstruct seawater pH using radiocarbon as a novel tracer of carbon dioxide ....Bubble, Bubble CO2 is the trouble: A Natural Ocean Acidification Experiment in a coral reef setting. Carbon dioxide seep sites expose shallow coral reefs in Papua New Guinea to volcanic carbon dioxide resulting in gradients of seawater ranging from pH 8.0 (normal) to a more acidic pH of 7.5. Some areas of these reefs experience carbon dioxide exposure equivalent to IPCC predictions for 2050 and 2100. This project will reconstruct seawater pH using radiocarbon as a novel tracer of carbon dioxide input at a coral reef site that has been exposed to high carbon dioxide due to volcanic seeps (seep carbon dioxide has no carbon-14) for an unknown period of time (at least many decades, but possibly centuries). These results will help to understand the time it takes to change calcifying organisms into “winners” or “losers” as an analog for Ocean Acidification due to increased atmospheric carbon dioxide input.Read moreRead less