Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989539
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Purchase of a state-of-the-art high resolution inductively coupled plasma mass spectrometer. This new state-of-the-art mass spectrometer with enhanced capability will allow Tasmanian researchers to accurately determine the elemental composition of their samples of interest. The instrument will be extremely sensitive and will be able to detect elements to very low concentrations. It will be used to support a diverse range of local research projects of international significance, for example the ....Purchase of a state-of-the-art high resolution inductively coupled plasma mass spectrometer. This new state-of-the-art mass spectrometer with enhanced capability will allow Tasmanian researchers to accurately determine the elemental composition of their samples of interest. The instrument will be extremely sensitive and will be able to detect elements to very low concentrations. It will be used to support a diverse range of local research projects of international significance, for example the environmental assessment of clean and contaminated sites, chemical synthesis on a miniature scale using micro-chips, and the monitoring of selected elements of key importance for human health.Read moreRead less
Southern Ocean productivity and carbon dioxide (CO2) exchange under current and future climate regimes. This project will contribute to Australian ocean science expertise in key areas of data synthesis, satellite oceanography and the understanding of marine ecosystems' response to climate change. Collaborations will be developed and strengthened among Australian research institutions, and between Australia and the United States. The focus of the research is the Southern Ocean, which impacts glob ....Southern Ocean productivity and carbon dioxide (CO2) exchange under current and future climate regimes. This project will contribute to Australian ocean science expertise in key areas of data synthesis, satellite oceanography and the understanding of marine ecosystems' response to climate change. Collaborations will be developed and strengthened among Australian research institutions, and between Australia and the United States. The focus of the research is the Southern Ocean, which impacts global climate, and on which Australia's southern coastal ecosystems depend. The expertise and techniques developed will have application to other Australian regional seas.Read moreRead less
Microfluidic technology to help understand physical damage to brain cells. Understanding the organisation, structure and mechanisms of the human brain and nervous system remains one of the biggest challenges of science. This project aims to develop a new cell culture platform to form defined molecular networks of brain cells and to monitor changes throughout the network in response to a small localised injury within the network. This innovative platform will be used to help understand changes wi ....Microfluidic technology to help understand physical damage to brain cells. Understanding the organisation, structure and mechanisms of the human brain and nervous system remains one of the biggest challenges of science. This project aims to develop a new cell culture platform to form defined molecular networks of brain cells and to monitor changes throughout the network in response to a small localised injury within the network. This innovative platform will be used to help understand changes within cells in response to physical damage to networks of brain cells. This is one of the major causes of death and disability in developed nations, and is identified as a risk factor for a range of neurodegenerative diseases including Alzheimer's, Parkinson's and motor neuron disease.Read moreRead less
Harnessing light and electricity to drive chemical synthesis. This project will explore and establish original strategies that use inputs of energy (light and electricity) to break or form chemical bonds, which can provide new or improved access to valuable compounds. In this way, this research will augment or enhance existing methods for the selective and direct manipulation of molecules by creating tools that allow chemists to prepare molecules under particularly mild conditions. The outcomes ....Harnessing light and electricity to drive chemical synthesis. This project will explore and establish original strategies that use inputs of energy (light and electricity) to break or form chemical bonds, which can provide new or improved access to valuable compounds. In this way, this research will augment or enhance existing methods for the selective and direct manipulation of molecules by creating tools that allow chemists to prepare molecules under particularly mild conditions. The outcomes of the project will include the development of new technology for organic synthesis and forging novel approaches for chemical alkylation and cross-coupling reactions. This can contribute to making important compounds more efficiently, safely and cheaper to produce in the future.Read moreRead less
Advanced micro analysis systems for environmental monitoring. Understanding of the behaviour of the nutrients controlling nuisance algae in water bodies is currently limited by the cost and logistics of collecting and analysing the large numbers of samples required.
This proposal describes the development and evaluation of portable multiparameter micro analysis systems that will be capable of high frequency measurements from a sampling vessel. This will enable environmental agencies to perfo ....Advanced micro analysis systems for environmental monitoring. Understanding of the behaviour of the nutrients controlling nuisance algae in water bodies is currently limited by the cost and logistics of collecting and analysing the large numbers of samples required.
This proposal describes the development and evaluation of portable multiparameter micro analysis systems that will be capable of high frequency measurements from a sampling vessel. This will enable environmental agencies to perform rapid on-site mapping of nutrients and other water quality parameters in large water bodies, intensive scale mapping of effluent mixing and dispersal zones, quick assessment of the impact of dredging and aquaculture, and compliance monitoring in effluent streams.
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Iron in the Antarctic sea ice zone and its role in the past and future climate. The Antarctic sea ice environment has remained poorly investigated for decades as it is difficult to access. Recent scientific advances have revealed that melting sea ice may provide a significant amount of the plant micro-nutrient iron to the Southern Ocean. Given that polar waters are iron-deficient and seasonal sea ice affects ~14 million square kilometres of ocean, the importance of iron fertilisation from deca ....Iron in the Antarctic sea ice zone and its role in the past and future climate. The Antarctic sea ice environment has remained poorly investigated for decades as it is difficult to access. Recent scientific advances have revealed that melting sea ice may provide a significant amount of the plant micro-nutrient iron to the Southern Ocean. Given that polar waters are iron-deficient and seasonal sea ice affects ~14 million square kilometres of ocean, the importance of iron fertilisation from decaying sea ice and its effect on global climate urgently need to be evaluated. This proposal aims at improving our understanding of Earth's complex system, and will inform future climate change policy in Australia.
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Switchable and stereocontrolled photoredox catalysis. This project aims to develop new catalytic synthetic reactions for the rapid and more direct functionalisation of organic compounds under mild conditions with the use of visible light. An integrated experimental and computational approach will be used to design potent visible-light photocatalysts that retain the advantages of standard photoredox catalysis but with the added ability to intercept and, thus control, reactive intermediates in sit ....Switchable and stereocontrolled photoredox catalysis. This project aims to develop new catalytic synthetic reactions for the rapid and more direct functionalisation of organic compounds under mild conditions with the use of visible light. An integrated experimental and computational approach will be used to design potent visible-light photocatalysts that retain the advantages of standard photoredox catalysis but with the added ability to intercept and, thus control, reactive intermediates in situ. This will enable the control of stereochemistry in photoredox reactions – not possible with standard catalysts - and establish other useful synthetic transformations. These strategies will make it easier to prepare valuable classes of organic molecules – efficiently, safely, and cost-effectively.
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Microreactors for Organic Synthesis. Since the electronic revolution, miniaturisation has been the trend for devices from consumer electronics to scientific instruments. In this time very little has changed in the manner, or scale, that synthetic organic chemistry has been carried out even though advances in instrumentation mean that less compound is required for identification and analysis. This project aims to bridge the gap by developing recyclable miniaturised reaction vessels for the format ....Microreactors for Organic Synthesis. Since the electronic revolution, miniaturisation has been the trend for devices from consumer electronics to scientific instruments. In this time very little has changed in the manner, or scale, that synthetic organic chemistry has been carried out even though advances in instrumentation mean that less compound is required for identification and analysis. This project aims to bridge the gap by developing recyclable miniaturised reaction vessels for the formation of organic compounds on a scale thousands of times smaller than it is currently done. These devices will have applications in drug discovery programmes due to higher throughput and increased efficiency while minimising waste.Read moreRead less
Binuclear palladium motifs in synthetic transformations. Reactions involving palladium compounds with organic reagents are important for synthesis of new materials, pharmaceuticals, and molecules of value in medical research. This project will provide a better understanding of applications of palladium in these fields, and structural features of compounds containing chemical bonds linking metal atoms.
Targeting organically-complexed iron species in seawater using selective solid-phase adsorbent resins. Iron limits primary productivity in 40% of the oceans. Its accurate determination is thus critical to understanding the functioning of marine ecosystems and their role in moderating Earth's climate. Recent findings indicate that serious discrepancies exist in iron concentrations obtained using different analytical methods. These discrepancies are believed to be due to the lability of organic ....Targeting organically-complexed iron species in seawater using selective solid-phase adsorbent resins. Iron limits primary productivity in 40% of the oceans. Its accurate determination is thus critical to understanding the functioning of marine ecosystems and their role in moderating Earth's climate. Recent findings indicate that serious discrepancies exist in iron concentrations obtained using different analytical methods. These discrepancies are believed to be due to the lability of organic and colloidal iron species to extraction by adsorbent preconcentration resins. This project will design and synthesise a range of functionalised resins for the selective extraction of iron species from seawater, advancing our knowledge of its bioavailability and leading to the generation of class-specific analytical methodologies.Read moreRead less