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Microreactors for Organic Synthesis. Since the electronic revolution, miniaturisation has been the trend for devices from consumer electronics to scientific instruments. In this time very little has changed in the manner, or scale, that synthetic organic chemistry has been carried out even though advances in instrumentation mean that less compound is required for identification and analysis. This project aims to bridge the gap by developing recyclable miniaturised reaction vessels for the format ....Microreactors for Organic Synthesis. Since the electronic revolution, miniaturisation has been the trend for devices from consumer electronics to scientific instruments. In this time very little has changed in the manner, or scale, that synthetic organic chemistry has been carried out even though advances in instrumentation mean that less compound is required for identification and analysis. This project aims to bridge the gap by developing recyclable miniaturised reaction vessels for the formation of organic compounds on a scale thousands of times smaller than it is currently done. These devices will have applications in drug discovery programmes due to higher throughput and increased efficiency while minimising waste.Read moreRead less
High Oxidation State and Related Chemistry of Organic Compounds of Palladium. Palladium is able to form compounds containing palladium-carbon bonds, and compounds of this type occur in applications such as synthesis of organic compounds. The fundamental chemistry of this class of palladium compound is to be explored, in particular for the oxidation state +IV for palladium and with a focus on reactions that are relevant to processes occurring in organic synthesis applications. Particular emphas ....High Oxidation State and Related Chemistry of Organic Compounds of Palladium. Palladium is able to form compounds containing palladium-carbon bonds, and compounds of this type occur in applications such as synthesis of organic compounds. The fundamental chemistry of this class of palladium compound is to be explored, in particular for the oxidation state +IV for palladium and with a focus on reactions that are relevant to processes occurring in organic synthesis applications. Particular emphasis is placed on chemistry involving phosphorus compounds and unsaturated organic groups bonded to palladium, and on compounds containing groups that are able to join together to depart from palladium as organic compounds containing carbon-oxygen bonds.Read moreRead less
New Directions in Alkynylpalladium and Platinum Chemistry. Reactions involving palladium or platinum compounds with organic reagents are important for the synthesis of new materials and organic molecules, including pharmaceuticals. This research program will provide a better understanding of applications involving these metals, together with advances in fundamental chemistry of wide general interest at an international level, and high quality research training in an area essential for the conti ....New Directions in Alkynylpalladium and Platinum Chemistry. Reactions involving palladium or platinum compounds with organic reagents are important for the synthesis of new materials and organic molecules, including pharmaceuticals. This research program will provide a better understanding of applications involving these metals, together with advances in fundamental chemistry of wide general interest at an international level, and high quality research training in an area essential for the continued development of modern chemical and related industries in Australia.Read moreRead less
Highly integrated miniaturised total analysis systems for pharmaceuticals in biological and environmental samples. This project will develop three unique chemical approaches that will each overcome a challenge to the creation of advanced miniaturised analytical devices with sample-in/answer-out capability. This will provide substantial improvements in speed, cost, portability, and operational simplicity and safety. New technology for analysing drugs in body fluids will be critical to enabling pe ....Highly integrated miniaturised total analysis systems for pharmaceuticals in biological and environmental samples. This project will develop three unique chemical approaches that will each overcome a challenge to the creation of advanced miniaturised analytical devices with sample-in/answer-out capability. This will provide substantial improvements in speed, cost, portability, and operational simplicity and safety. New technology for analysing drugs in body fluids will be critical to enabling people to closely match their pharmaceutical consumption with their individual requirements. The advance will have implications for all patients, particularly those in remote and rural Australian populations. The same technology is likely to find applications in environmental monitoring of emerging pharmaceutical pollutants. Read moreRead less
Binuclear palladium motifs in synthetic transformations. Reactions involving palladium compounds with organic reagents are important for synthesis of new materials, pharmaceuticals, and molecules of value in medical research. This project will provide a better understanding of applications of palladium in these fields, and structural features of compounds containing chemical bonds linking metal atoms.
Microfluidic technology to help understand physical damage to brain cells. Understanding the organisation, structure and mechanisms of the human brain and nervous system remains one of the biggest challenges of science. This project aims to develop a new cell culture platform to form defined molecular networks of brain cells and to monitor changes throughout the network in response to a small localised injury within the network. This innovative platform will be used to help understand changes wi ....Microfluidic technology to help understand physical damage to brain cells. Understanding the organisation, structure and mechanisms of the human brain and nervous system remains one of the biggest challenges of science. This project aims to develop a new cell culture platform to form defined molecular networks of brain cells and to monitor changes throughout the network in response to a small localised injury within the network. This innovative platform will be used to help understand changes within cells in response to physical damage to networks of brain cells. This is one of the major causes of death and disability in developed nations, and is identified as a risk factor for a range of neurodegenerative diseases including Alzheimer's, Parkinson's and motor neuron disease.Read moreRead less
Towards Microfluidic-Based Advanced Remote Analysis. The research under this project will establish and systematically develop Advanced Remote Analysis as a new inter-disciplinary area and establish a leadership role for Australia. By addressing pressing needs such as monitoring the environment, remote medical diagnostics, advancing Australian science and technology, or monitoring for traces of explosives, this project falls directly into all four of the National Research Priorities with applica ....Towards Microfluidic-Based Advanced Remote Analysis. The research under this project will establish and systematically develop Advanced Remote Analysis as a new inter-disciplinary area and establish a leadership role for Australia. By addressing pressing needs such as monitoring the environment, remote medical diagnostics, advancing Australian science and technology, or monitoring for traces of explosives, this project falls directly into all four of the National Research Priorities with applications addressing corresponding Priority Goals. Other areas benefiting from the outcomes of this project will be remote monitoring of agricultural production including living species, and a number of other industries such as biotechnology, mineral processing, power generation etc.Read moreRead less
In-line SPE-CE for the direct determination of drugs and metabolites in biological fluids based on porous polymer monoliths. A new approach is proposed for the development of novel micro- and nano-scale solid-phase adsorbent materials. These materials are based on porous polymer monoliths formed in situ within a capillary acting as a mould. The allows the material to be readily placed in a defined position, in a process similar to photo-patterning, and alleviates many of the problems usually as ....In-line SPE-CE for the direct determination of drugs and metabolites in biological fluids based on porous polymer monoliths. A new approach is proposed for the development of novel micro- and nano-scale solid-phase adsorbent materials. These materials are based on porous polymer monoliths formed in situ within a capillary acting as a mould. The allows the material to be readily placed in a defined position, in a process similar to photo-patterning, and alleviates many of the problems usually associated with fabrication and miniaturisation. A simple photo-grafting process, initiated by UV light can be used for the selective chemical modification of these materials. These tailored monoliths can then be used for the in-line coupling of biological sample handling and capillary electrophoresis (CE) for the determination of drugs and related metabolites in biological fluids, thus avoiding time-consuming and costly off-line sample pre-treatment. This will lead to the development of new methods for the rapid determination of drugs, metabolites and other small molecules in clinical samples.Read moreRead less
3D seismic velocity structure for geothermal exploration: a novel approach combining ambient and passive seismic methods. Australia hosts many geological locations that have the potential for geothermal energy production. This is a sustainable power resource and employs diverse technological approaches depending on local conditions. We aim to pilot a new seismic imaging method, which could become a standard in geothermal exploration around the world, to investigate natural heat sources buried ....3D seismic velocity structure for geothermal exploration: a novel approach combining ambient and passive seismic methods. Australia hosts many geological locations that have the potential for geothermal energy production. This is a sustainable power resource and employs diverse technological approaches depending on local conditions. We aim to pilot a new seismic imaging method, which could become a standard in geothermal exploration around the world, to investigate natural heat sources buried in the crust. Tasmania is an ideal pilot location with active geothermal exploration tenements held by a locally-based company.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100018
Funder
Australian Research Council
Funding Amount
$630,000.00
Summary
Purchase of a high resolution Nuclear Magnetic Resonance spectrometer with liquid chromatography module. A high resolution Nuclear Magnetic Resonance spectrometer and liquids separation module will support Tasmanian research of international significance across the biological and medical sciences, chemistry and Tasmanian industries including profiling studies in human health, plant biology, molecular basis of disease and complex mixture analysis.