Microfluidic Studies of Stimuli-Responsive Emulsions. Breakthrough 'stimuli-responsive interface technology' has been developed in Australia to allow better control over emulsions, which are oil-in-water mixtures used widely in everyday products such as medicines. This project will increase our understanding of this new technology, by examining how the chemistry of the molecules at the interface interacts with fluid behaviour when the emulsion is made. The research will employ miniature lab-on-a ....Microfluidic Studies of Stimuli-Responsive Emulsions. Breakthrough 'stimuli-responsive interface technology' has been developed in Australia to allow better control over emulsions, which are oil-in-water mixtures used widely in everyday products such as medicines. This project will increase our understanding of this new technology, by examining how the chemistry of the molecules at the interface interacts with fluid behaviour when the emulsion is made. The research will employ miniature lab-on-a-chip systems, to give engineers and scientists design rules for this new technology, opening the way to new products that will improve our everyday lives. One immediate product to be researched is 'precision' double emulsions, which show unique properties for the delivery of chemotherapy medicines.Read moreRead less
Production and nano-characterisation of II-VI semiconductor quantum dots from plant cell cultures. Nanocrystallites with semiconductor properties have potential applications in medicine, microelectronics and waste treatment. Cheap, reliable methods for producing large quantities of monodisperse nanoparticles are required. Solution techniques have been used most commonly; however, production of stable, high-quality particles remains difficult. Biological synthesis using plant cell culture offers ....Production and nano-characterisation of II-VI semiconductor quantum dots from plant cell cultures. Nanocrystallites with semiconductor properties have potential applications in medicine, microelectronics and waste treatment. Cheap, reliable methods for producing large quantities of monodisperse nanoparticles are required. Solution techniques have been used most commonly; however, production of stable, high-quality particles remains difficult. Biological synthesis using plant cell culture offers several important advantages. As peptide capping is incorporated into the biological assembly process, the nanoparticles are restricted in size, their stability is improved, and their surfaces are passivated. Application of plant cultures for nanocrystallite production is a novel approach with the potential to yield significant improvements in the quality of manufactured quantum dots.Read moreRead less
Engineering Nanostructured Bio-inspired Products. New nanostructured products that draw on biology promise to revolutionise our lives and economy. Designer emulsions and self-assembling particles inspired by viruses are two such products that form the focus for this research programme. The constitutive behaviour of bio-molecular films that control emulsion performance will be characterised and linked to molecular properties and manufacturing conditions. A broad-based technology platform for t ....Engineering Nanostructured Bio-inspired Products. New nanostructured products that draw on biology promise to revolutionise our lives and economy. Designer emulsions and self-assembling particles inspired by viruses are two such products that form the focus for this research programme. The constitutive behaviour of bio-molecular films that control emulsion performance will be characterised and linked to molecular properties and manufacturing conditions. A broad-based technology platform for the in vitro creation of self-assembling biological nanoparticles will also be developed. Key outcomes will be valuable IPR and fundamental engineering science knowledge to ensure that the value chain for this class of products can deliver commercial outcomes.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560662
Funder
Australian Research Council
Funding Amount
$204,157.00
Summary
Flow Diagnostics Facility for Microstructured Systems. This Project will establish Australia's only world-class facility for the interrogation of steady and fluctuating flows in microstructured components, enabling detailed characterisation of the flow patterns and velocities that occur in single phase and multiphase flows in miniature devices. Such devices are currently being developed by the Chief Investigators in the area of microreactor technology and chemical process intensification, in mic ....Flow Diagnostics Facility for Microstructured Systems. This Project will establish Australia's only world-class facility for the interrogation of steady and fluctuating flows in microstructured components, enabling detailed characterisation of the flow patterns and velocities that occur in single phase and multiphase flows in miniature devices. Such devices are currently being developed by the Chief Investigators in the area of microreactor technology and chemical process intensification, in microelectromechanical systems (MEMS), and in high efficiency membrane separation systems. The new Facility will enable them and others to enhance their research through visualisation and quantification of flow behaviour at the scale of a few micrometres.Read moreRead less
Sustainable processes for next-generation surface coatings and core-shell nanoparticles based on biomolecular templating. Nanotechnology promises new materials with broad impact, yet our ability to manufacture complex nanomaterials using sustainable processes is very limited. This project will advance our knowledge of nanomaterial manufacture using inspiration from how complex materials are made in nature. This project will deliver next-generation surface coatings that are incredibly thin but st ....Sustainable processes for next-generation surface coatings and core-shell nanoparticles based on biomolecular templating. Nanotechnology promises new materials with broad impact, yet our ability to manufacture complex nanomaterials using sustainable processes is very limited. This project will advance our knowledge of nanomaterial manufacture using inspiration from how complex materials are made in nature. This project will deliver next-generation surface coatings that are incredibly thin but strong, and specialised nanoparticles made using biocompatible processes. The knowledge and methods developed will benefit the biotechnology and nanotechnology sectors, as well as research in soft-matter science, quantum computing, photonics and healthcare. The value proposition for innovation in these fields will increasingly rely on new nanomanufacturing approaches.Read moreRead less
Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities ....Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities to address current limitations in understanding the stability of magnetic nanoparticles in biological fluids. The Australian partners will play a leading role in commercializing new applications for functionalized magnetic nanoparticles. The project will provide an excellent multidisciplinary research environment and training for early career researchers.Read moreRead less
Tailoring nano-crystal suspensions for extended ion supply to hydrophobic and hydrophilic leaf surfaces. Nutrient deficiency undermines the potential of billions of people and many nations. The requirement is to rapidly increase micro-nutrient delivery to support intensive and fortified crop production. This proposal seeks to develop a controlled ion release system through the use of tailored suspensions of nano-crystal nutrient materials for delivery to plants through the leaves. This will incr ....Tailoring nano-crystal suspensions for extended ion supply to hydrophobic and hydrophilic leaf surfaces. Nutrient deficiency undermines the potential of billions of people and many nations. The requirement is to rapidly increase micro-nutrient delivery to support intensive and fortified crop production. This proposal seeks to develop a controlled ion release system through the use of tailored suspensions of nano-crystal nutrient materials for delivery to plants through the leaves. This will increase yields from arable land, reduce water requirements and fertiliser applications, fortifying foods for better nutrition leading to improved human health and wellbeing. It leverages and applies recent significant advances in surface science and nanotechnology to gain improved outcomes in agriculture.Read moreRead less
Utilisation of dense gas technology for the development of controlled release active pharmaceutical ingredients (API) delivery systems. The aim of this project is to develop an orally administered drug formulation for the treatment of irritable bowel syndrome and other diseases of the colon. Irritable bowel syndrome is a debilitating condition and the cost to society is similar to that of asthma. As such, the project has the potential to have a major impact on society.
Innovative green technology for bio-particle engineering. Approximately 40% of new pharmaceuticals are poorly soluble in bodily fluids. In many cases this leads to poor bioavailability, and consequent undesirable side effects as a result of high compensating dosages and generally poor patient compliance. These issues will be addressed by developing a green technology for the re-engineering of pharmaceuticals with the objective of increasing bioavilability. The research programme falls within th ....Innovative green technology for bio-particle engineering. Approximately 40% of new pharmaceuticals are poorly soluble in bodily fluids. In many cases this leads to poor bioavailability, and consequent undesirable side effects as a result of high compensating dosages and generally poor patient compliance. These issues will be addressed by developing a green technology for the re-engineering of pharmaceuticals with the objective of increasing bioavilability. The research programme falls within the Designated Research Priority of Frontier Technologies for Building and Transforming Australian Industries. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453823
Funder
Australian Research Council
Funding Amount
$445,124.00
Summary
Atomic Force Microscopy Facility for Soft Interfaces. This proposal seeks to establish a specialized atomic force microscopy facility capable of performing measurements on nanometre scales at soft interfaces. This will service the needs of and collaboration between leading researchers at the Universities of Newcastle, Melbourne, New South Wales and James Cook University. The facility will allow direct measurements of properties of the interactions between atoms, molecules and surfaces associated ....Atomic Force Microscopy Facility for Soft Interfaces. This proposal seeks to establish a specialized atomic force microscopy facility capable of performing measurements on nanometre scales at soft interfaces. This will service the needs of and collaboration between leading researchers at the Universities of Newcastle, Melbourne, New South Wales and James Cook University. The facility will allow direct measurements of properties of the interactions between atoms, molecules and surfaces associated with soft interfaces which are required for ongoing research in fluid-fluid interfaces, surfactant and polymer adsorbed layers, and biomolecules as well as to develop new processes in emerging fields of nanotechnology, biotechnology, and medical and pharmaceutical production.Read moreRead less