Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microflu ....Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microfluidic platform technology for reproducibly producing targeted polymer nanocarriers having systematically varied properties, a dual-templating method for making targeted silica nanocapsules and new design of in vivo-mimicking 'Tissue Chips' for screening and evaluating the nanocarriers.Read moreRead less
Solar-driven thermochemical dissociation of carbon dioxide and water to produce carbon-neutral fuels. The biggest challenge to humanity of the century is to develop enabling clean energy resources to encounter rapidly diminished fossil fuel and accelerated global warming conditions. This project will offer a solution by developing a unique solar-driven thermochemical system capable of cleaving carbon dioxide and water to produce artificial syngas.
Two-dimensional nanoporous structured high performance gas evolution electrocatalysts. This project aims to develop nano-catalysts with high catalytic activity and rapid gas detachment properties for efficient fuel gas production. Heterogeneous electrocatalytic gas evolution reactions are important for clean energy generation and storage technologies, but high overpotentials caused by slow gaseous products’ detachment from catalyst surface severely hinder their efficiencies. Expected outcomes in ....Two-dimensional nanoporous structured high performance gas evolution electrocatalysts. This project aims to develop nano-catalysts with high catalytic activity and rapid gas detachment properties for efficient fuel gas production. Heterogeneous electrocatalytic gas evolution reactions are important for clean energy generation and storage technologies, but high overpotentials caused by slow gaseous products’ detachment from catalyst surface severely hinder their efficiencies. Expected outcomes include insights into gas bubble formation and evolution during electrocatalysis, effective catalyst structures to mitigate negative effects of gas bubble formation, and improved catalytic efficiency of gas evolution reactions and develop high performance electrocatalysts for fuel gas production.Read moreRead less
Smart self-propelled nanoreactors for catalytic environmental remediation. This project aims to develop nanomaterial design and technology to enable the applications of nanotechnology for environmental remediation. Various nanomotors with different asymmetric structures will be fabricated and tested for catalytic and photocatalytic degradation of aqueous pollutants. The physicochemical properties, motion behaviour and catalytic performance will be comprehensively investigated. The outcomes of th ....Smart self-propelled nanoreactors for catalytic environmental remediation. This project aims to develop nanomaterial design and technology to enable the applications of nanotechnology for environmental remediation. Various nanomotors with different asymmetric structures will be fabricated and tested for catalytic and photocatalytic degradation of aqueous pollutants. The physicochemical properties, motion behaviour and catalytic performance will be comprehensively investigated. The outcomes of the project will underpin the development of green technologies for sustainable energy conversion and water treatment. This will provide significant benefits, putting Australia in a leading position in the sustainable development of nanotechnology for sustainable energy supply and transformation as well as environmental and biomedical applications.Read moreRead less
Safe and efficient biomedical nanomaterials. This project aims to rationally engineer nanomaterials with controlled biological responses. Nanomaterials are becoming widespread in biomedicine and engineering, but are inefficient and unsafe. This project will develop atomic scale models to understand interactions between engineered nanoparticles and the crowded cellular environment. It will design extremely sensitive biosensors and theranostic nanodevices combining medical imaging capacity with pr ....Safe and efficient biomedical nanomaterials. This project aims to rationally engineer nanomaterials with controlled biological responses. Nanomaterials are becoming widespread in biomedicine and engineering, but are inefficient and unsafe. This project will develop atomic scale models to understand interactions between engineered nanoparticles and the crowded cellular environment. It will design extremely sensitive biosensors and theranostic nanodevices combining medical imaging capacity with precision targeted drug delivery to improve efficiency and safety of nanomaterials for biomedical applications in both vitro and in vivo enabling cost effective early diagnostics and more efficient treatments.Read moreRead less
Understanding biomolecular interactions of nanoparticles for engineering efficient biomedical materials and devices. Recent studies suggest that proteins bind differently to nano-patterned materials. This phenomenon holds a great potential for engineering of novel materials and devices for biomedical applications. At the same time, there are increasing concerns due to formation of biomolecular "coronas" of nanoparticles which can change their biological identity. This project will develop knowle ....Understanding biomolecular interactions of nanoparticles for engineering efficient biomedical materials and devices. Recent studies suggest that proteins bind differently to nano-patterned materials. This phenomenon holds a great potential for engineering of novel materials and devices for biomedical applications. At the same time, there are increasing concerns due to formation of biomolecular "coronas" of nanoparticles which can change their biological identity. This project will develop knowledge of the molecular mechanisms of nanomaterials interactions with molecular components of biological environment which will be exploited to improve molecular recognition needed in biosensors and drug delivery applications. The project outcomes will help formulate rational design principles for efficient biomedical materials and nanodevices.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100205
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
A novel high-pressure system for multiple gas adsorption. This facility will equip researchers with analytical capabilities for research in the field of multi-gas adsorption. The facility will be of great significance to clean energy research, such as greenhouse gas emission control and hydrogen production and storage.
Nanostructured Electrocatalysts for Clean Fuels Production. This project aims to develop single-component and hybrid transition-metal and metal-free electrocatalysts with controllable nanostructures to efficiently and selectively catalyse carbon dioxide reduction and hydrogen evolution reactions for clean fuels production including hydrogen and low-carbon organic molecules. By combining experimental and theoretical modelling, this project plans to reveal the origins, mechanism and pathway of the ....Nanostructured Electrocatalysts for Clean Fuels Production. This project aims to develop single-component and hybrid transition-metal and metal-free electrocatalysts with controllable nanostructures to efficiently and selectively catalyse carbon dioxide reduction and hydrogen evolution reactions for clean fuels production including hydrogen and low-carbon organic molecules. By combining experimental and theoretical modelling, this project plans to reveal the origins, mechanism and pathway of these reactions, and the effect of catalyst composition and morphology on their performance. The resulting nanostructured catalysts are of great importance for feasible clean fuel generation and carbon dioxide reduction.Read moreRead less
Development of novel cathodes for next generation solid oxide fuel cells. This project will provide novel cathodes to reduce the operating temperature of the Solid Oxide Fuel Cell (SOFC) as low as 500 degrees celsius. The technology may lead to widespread utilization of SOFCs, thus providing great assistance to Australia's industries in term of reducing carbon dioxide emission and easing pressure from carbon tax.