Discovery Early Career Researcher Award - Grant ID: DE230101044
Funder
Australian Research Council
Funding Amount
$444,318.00
Summary
Bio-inspired nanomaterials with tunable drug loading and controlled release. This project aims to develop new platform technologies for making bio-inspired nanomaterials with tunable drug loading and controlled release. This project will revolutionise current approaches to make lipid nanoparticles camouflaged with natural cell membranes for delivery of both insoluble and soluble drugs. Significant outcomes will include a novel commercially relevant salt-induced nanoprecipitation platform technol ....Bio-inspired nanomaterials with tunable drug loading and controlled release. This project aims to develop new platform technologies for making bio-inspired nanomaterials with tunable drug loading and controlled release. This project will revolutionise current approaches to make lipid nanoparticles camouflaged with natural cell membranes for delivery of both insoluble and soluble drugs. Significant outcomes will include a novel commercially relevant salt-induced nanoprecipitation platform technology for making precisely engineered nanomaterials with tailored functions for applications in controlled release and targeted delivery. Benefits include securing a sustainable future for Australia, with new nanotechnology strategies for advanced manufacturing.Read moreRead less
Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipi ....Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.Read moreRead less
Mechanical modulation of particle-cell interactions. Mechanical forces play critical roles in many biological processes, but how particle mechanical properties modulate particle-cell interactions remains elusive. This project aims to develop new design principles for engineering nano/micromaterials with tunable mechanical properties for improved cell activation and expansion, and to advance knowledge of the role of particle stiffness in modulating receptor-mediated particle-cell interactions. Ex ....Mechanical modulation of particle-cell interactions. Mechanical forces play critical roles in many biological processes, but how particle mechanical properties modulate particle-cell interactions remains elusive. This project aims to develop new design principles for engineering nano/micromaterials with tunable mechanical properties for improved cell activation and expansion, and to advance knowledge of the role of particle stiffness in modulating receptor-mediated particle-cell interactions. Expected outcomes and benefits include new fundamental understanding of the effect of particle mechanical properties on cell function, new insights into T cell activation and expansion, and new classes of stiffness-tunable fit-for-purpose materials for various applications in cell manufacturing.Read moreRead less
Development of Novel Metaconcrete to Resist Impulsive Loads. This project aims to develop innovative metaconcrete for structural protection by utilising the concept of phononic crystals and metamaterials which has been recently developed by physicists. Traditional construction materials are used in new structural forms to mitigate dynamic loading effects by exploiting the unique characteristics of the proposed metaconcrete. Theoretical, numerical and experimental methods will be used to derive t ....Development of Novel Metaconcrete to Resist Impulsive Loads. This project aims to develop innovative metaconcrete for structural protection by utilising the concept of phononic crystals and metamaterials which has been recently developed by physicists. Traditional construction materials are used in new structural forms to mitigate dynamic loading effects by exploiting the unique characteristics of the proposed metaconcrete. Theoretical, numerical and experimental methods will be used to derive the best performing metaconcrete and verify its static and dynamic load resistant capacities. The expected outcomes of the project will lead to innovative extreme-loading resistant designs and provide significant benefit to the Australian construction industry, general public and economy.Read moreRead less
Microfluidics with core-shell beads: handling liquids like solids. Reducing waste of consumables in chemical reactions promises to solve environmental problems as well as enable novel applications in space. This project aims to establish a revolutionary fluid handling technology that lowers waste in the labs and in satellites. The project deciphers the fundamental physics behind our recent discovery of encapsulating a tiny liquid content in a solid shell, allowing for handling liquid samples lik ....Microfluidics with core-shell beads: handling liquids like solids. Reducing waste of consumables in chemical reactions promises to solve environmental problems as well as enable novel applications in space. This project aims to establish a revolutionary fluid handling technology that lowers waste in the labs and in satellites. The project deciphers the fundamental physics behind our recent discovery of encapsulating a tiny liquid content in a solid shell, allowing for handling liquid samples like solid particles. Examples of the benefit of this project are more precise detection of bacteria on earth and compact reactors in space. The research outcomes are instrumental for promoting a clean environment, good health, and creating new business opportunities, particularly in space industry, for Australians.Read moreRead less
Mitigating Vehicular Crashes into Masonry Buildings . Around 2000 vehicles crash annually into school, home and shop buildings located at close proximity to heavily trafficked roads in Australia and cause significant distress to occupants of building and vehicle. The impacted walls mostly of masonry, suffer severe damage often with vehicle intrusion into the building. Despite this, the intrusion mechanism is not understood and no effective mitigation strategies exist at present. This project wi ....Mitigating Vehicular Crashes into Masonry Buildings . Around 2000 vehicles crash annually into school, home and shop buildings located at close proximity to heavily trafficked roads in Australia and cause significant distress to occupants of building and vehicle. The impacted walls mostly of masonry, suffer severe damage often with vehicle intrusion into the building. Despite this, the intrusion mechanism is not understood and no effective mitigation strategies exist at present. This project will uncover the mechanics of vehicle intrusions through masonry walls and develop novel mitigation strategies using high energy absorbing auxetic composite render and innovative vibration isolation at wall edges. These innovations will lead to new theories that can save lives in the building and vehicle.Read moreRead less
Improved seismic resilience against life-safety hazard of masonry buildings. This project aims to develop a cost-effective technique to mitigate the safety risk posed by the many unreinforced brick masonry parapets and walls which are vulnerable to seismic shock. Every Australian city has many streets lined with older unreinforced brick masonry buildings (now cafes, pubs, boutique shops) which feature parapets. The project will provide benefits to society by reducing the potential for parapet co ....Improved seismic resilience against life-safety hazard of masonry buildings. This project aims to develop a cost-effective technique to mitigate the safety risk posed by the many unreinforced brick masonry parapets and walls which are vulnerable to seismic shock. Every Australian city has many streets lined with older unreinforced brick masonry buildings (now cafes, pubs, boutique shops) which feature parapets. The project will provide benefits to society by reducing the potential for parapet collapse and therefore reduce the total number of fatalities in an earthquake. Building owners and engineers will be benefit from the design guidance provided by this project, which will lead to a suite of fully-tested and low-cost retrofit techniques.Read moreRead less
Infrastructure on reactive soils: fundamental advances and validation. This project aims to advance fundamental knowledge on the complex behaviour of reactive soils in the context of resilient geotechnical infrastructure. This research falls within the research priority “Environmental Change”, as geotechnical infrastructure need to sustain the impact of ever more frequent and more intense climatic actions. Attention will focus on the effect of suction on volume change and shear strength of react ....Infrastructure on reactive soils: fundamental advances and validation. This project aims to advance fundamental knowledge on the complex behaviour of reactive soils in the context of resilient geotechnical infrastructure. This research falls within the research priority “Environmental Change”, as geotechnical infrastructure need to sustain the impact of ever more frequent and more intense climatic actions. Attention will focus on the effect of suction on volume change and shear strength of reactive soils, two poorly understood features, and will produce a swelling model and a soil-deformable structure interaction model. After validation by a case study, the models will have the potential to empower industry to produce geotechnical infrastructure that can better sustain climatic actions.Read moreRead less
Develop Catalyst Materials for Future Fuels by Operando Computation. This project aims to design catalyst materials for the production of future fuels (green ammonia, hydrocarbon and alcohol). Using carbon and nitrogen as energy carriers, these fuels are generated from renewable sources such as wind or solar; they are safe, reliable, and possess high energy density. The outcomes include advance in computational electrochemistry to the Opeando level, electrocatalysts design principles with clearl ....Develop Catalyst Materials for Future Fuels by Operando Computation. This project aims to design catalyst materials for the production of future fuels (green ammonia, hydrocarbon and alcohol). Using carbon and nitrogen as energy carriers, these fuels are generated from renewable sources such as wind or solar; they are safe, reliable, and possess high energy density. The outcomes include advance in computational electrochemistry to the Opeando level, electrocatalysts design principles with clearly articulated reaction mechanisms, and candidate materials for experimental validation. Facilitated by advanced computation techniques and reliable catalyst materials design procedure, this project will address the biggest challenge in future fuel generation, which is the lack of efficient catalyst materials. Read moreRead less
Multifunctional Structural Panels for Next-generation Infrastructure. This project aims to develop a multifunctional prefabricated structural panel for current and future infrastructure applications for both land and offshore environments. Prefabrication enables enhanced product control as well as the ability to rapidly construct whole structures or their components. The panels utilise an inner lightweight foam and fibre-reinforced polymer (FRP) composite core with strong outer panels made from ....Multifunctional Structural Panels for Next-generation Infrastructure. This project aims to develop a multifunctional prefabricated structural panel for current and future infrastructure applications for both land and offshore environments. Prefabrication enables enhanced product control as well as the ability to rapidly construct whole structures or their components. The panels utilise an inner lightweight foam and fibre-reinforced polymer (FRP) composite core with strong outer panels made from FRP sheets and high-strength concrete. The expected outcomes include experimental and numerical validation of the system, that will give designers and asset owners the confidence to adopt this new panel. The panel system presents an upward step change in construction technology and built infrastructure performance.Read moreRead less