Discovery Early Career Researcher Award - Grant ID: DE230101044
Funder
Australian Research Council
Funding Amount
$444,318.00
Summary
Bio-inspired nanomaterials with tunable drug loading and controlled release. This project aims to develop new platform technologies for making bio-inspired nanomaterials with tunable drug loading and controlled release. This project will revolutionise current approaches to make lipid nanoparticles camouflaged with natural cell membranes for delivery of both insoluble and soluble drugs. Significant outcomes will include a novel commercially relevant salt-induced nanoprecipitation platform technol ....Bio-inspired nanomaterials with tunable drug loading and controlled release. This project aims to develop new platform technologies for making bio-inspired nanomaterials with tunable drug loading and controlled release. This project will revolutionise current approaches to make lipid nanoparticles camouflaged with natural cell membranes for delivery of both insoluble and soluble drugs. Significant outcomes will include a novel commercially relevant salt-induced nanoprecipitation platform technology for making precisely engineered nanomaterials with tailored functions for applications in controlled release and targeted delivery. Benefits include securing a sustainable future for Australia, with new nanotechnology strategies for advanced manufacturing.Read moreRead less
Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will re ....Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will resolve uncertainties in the underlying phenomena. The expected outcome should support future high quality cell cultures suitable for transplantation therapies.Read moreRead less
Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipi ....Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.Read moreRead less
Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Desalting reclaimed wastewater to safeguard Virginia's horticultural industries. Virginia is a major horticultural region of South Australia undergoing rapid expansion. Groundwater resources are depleted and reclaimed sewage effluent from Adelaide is required for irrigation. Unfortunately, the effluent is frequently too saline. Large-scale desalting is being considered. A pilot-scale plant will be built to evaluate suitable desalting processes (e.g. reverse osmosis) for reducing the effluent ....Desalting reclaimed wastewater to safeguard Virginia's horticultural industries. Virginia is a major horticultural region of South Australia undergoing rapid expansion. Groundwater resources are depleted and reclaimed sewage effluent from Adelaide is required for irrigation. Unfortunately, the effluent is frequently too saline. Large-scale desalting is being considered. A pilot-scale plant will be built to evaluate suitable desalting processes (e.g. reverse osmosis) for reducing the effluent's salt content. Original research will: (i) synthesize the best combination of technologies to produce effluent streams of varying salinity for matching different crop requirements; and (ii) optimise delivery and storage of effluent streams using new storage(s) and the region's multiple aquifer and surface storages.Read moreRead less
Robust fluid mixing through topological chaos. The Australian chemicals and plastics industry has an annual turnover of over $20 billion and employs over 77,000 people; fluid mixing is fundamental to this industry, yet the industry is recognised as underinvesting in research and development in this essential area. Furthermore, frontier technologies such as biotechnology and the next generation of smart materials also crucially rely on fluid mixing. This project aims to evaluate a new paradigm ( ....Robust fluid mixing through topological chaos. The Australian chemicals and plastics industry has an annual turnover of over $20 billion and employs over 77,000 people; fluid mixing is fundamental to this industry, yet the industry is recognised as underinvesting in research and development in this essential area. Furthermore, frontier technologies such as biotechnology and the next generation of smart materials also crucially rely on fluid mixing. This project aims to evaluate a new paradigm (topological chaos) for the design of mixers, to provide better and more robust mixers that work from microscopic to industrial scales.Read moreRead less
Retrofitted brick masonry buildings - are they reliable over the long term? The aim of this project is to investigate the long-term reliability of a new earthquake strengthening technique for brick buildings. The technique involves the use of fibre reinforced polymer (FRP) strips as reinforcement for brick walls and has been shown to give substantial instantaneous strength increases. However, no research has been undertaken to ensure that the improved strength is sustained over the remaining lif ....Retrofitted brick masonry buildings - are they reliable over the long term? The aim of this project is to investigate the long-term reliability of a new earthquake strengthening technique for brick buildings. The technique involves the use of fibre reinforced polymer (FRP) strips as reinforcement for brick walls and has been shown to give substantial instantaneous strength increases. However, no research has been undertaken to ensure that the improved strength is sustained over the remaining life of the building. The only related research involves reinforced concrete which suggests that a reduction of at least 33 per cent could be expected. Hence, this project will quantify the long-term strength of FRP reinforced brickwork to enable engineers to safely apply this new cost-effective retrofit technique.Read moreRead less
Mechanical modulation of particle-cell interactions. Mechanical forces play critical roles in many biological processes, but how particle mechanical properties modulate particle-cell interactions remains elusive. This project aims to develop new design principles for engineering nano/micromaterials with tunable mechanical properties for improved cell activation and expansion, and to advance knowledge of the role of particle stiffness in modulating receptor-mediated particle-cell interactions. Ex ....Mechanical modulation of particle-cell interactions. Mechanical forces play critical roles in many biological processes, but how particle mechanical properties modulate particle-cell interactions remains elusive. This project aims to develop new design principles for engineering nano/micromaterials with tunable mechanical properties for improved cell activation and expansion, and to advance knowledge of the role of particle stiffness in modulating receptor-mediated particle-cell interactions. Expected outcomes and benefits include new fundamental understanding of the effect of particle mechanical properties on cell function, new insights into T cell activation and expansion, and new classes of stiffness-tunable fit-for-purpose materials for various applications in cell manufacturing.Read moreRead less
Development of Novel Metaconcrete to Resist Impulsive Loads. This project aims to develop innovative metaconcrete for structural protection by utilising the concept of phononic crystals and metamaterials which has been recently developed by physicists. Traditional construction materials are used in new structural forms to mitigate dynamic loading effects by exploiting the unique characteristics of the proposed metaconcrete. Theoretical, numerical and experimental methods will be used to derive t ....Development of Novel Metaconcrete to Resist Impulsive Loads. This project aims to develop innovative metaconcrete for structural protection by utilising the concept of phononic crystals and metamaterials which has been recently developed by physicists. Traditional construction materials are used in new structural forms to mitigate dynamic loading effects by exploiting the unique characteristics of the proposed metaconcrete. Theoretical, numerical and experimental methods will be used to derive the best performing metaconcrete and verify its static and dynamic load resistant capacities. The expected outcomes of the project will lead to innovative extreme-loading resistant designs and provide significant benefit to the Australian construction industry, general public and economy.Read moreRead less
Composite tubular construction subject to impact and blast loading. This project will advance the knowledge of composite tubular members and connections under impact and blast loading. It will provide confident design methodology against impact and blast loading for buildings designated as prominent targets or items of critical infrastructure, to save lives and reduce losses.