Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will re ....Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will resolve uncertainties in the underlying phenomena. The expected outcome should support future high quality cell cultures suitable for transplantation therapies.Read moreRead less
Next generation core-shell materials based on biomolecular dual-templating. This project aims to discover and develop new methods and knowledge for the precision engineering of next-generation core-shell materials using sustainable biomolecular dual-templating processes. This research builds on a recent breakthrough - emulsion and biomimetic dual-templating technology for facile preparation of silica capsules, and is expected to revolutionise current approaches for making core-shell materials. S ....Next generation core-shell materials based on biomolecular dual-templating. This project aims to discover and develop new methods and knowledge for the precision engineering of next-generation core-shell materials using sustainable biomolecular dual-templating processes. This research builds on a recent breakthrough - emulsion and biomimetic dual-templating technology for facile preparation of silica capsules, and is expected to revolutionise current approaches for making core-shell materials. Significant outcomes are expected to be achieved through building fundamental understanding around this breakthrough, including new concepts for hierarchical nanomaterials based on biomolecular design, new molecular and engineering design rules for core-shell materials, and novel materials for applications in sustained release and delivery systems.Read moreRead less
Dynamic Controllability Analysis for Plantwide Process Design and Control. World-wide chemical plants represent many billions of dollars of investment. Improvements to the process designs in terms of controllability would have the potential to provide large economic benefits, as it implies improved productivity, reduced operating costs and product variability. This proposed research will be a step towards integration of process design and control, which has been widely recognized as the key to t ....Dynamic Controllability Analysis for Plantwide Process Design and Control. World-wide chemical plants represent many billions of dollars of investment. Improvements to the process designs in terms of controllability would have the potential to provide large economic benefits, as it implies improved productivity, reduced operating costs and product variability. This proposed research will be a step towards integration of process design and control, which has been widely recognized as the key to this improvement. The outcomes from this project may be readily implemented in process design practice, and therefore have a direct impact to the Australian and world-wide process industries, helping to build a more efficient and environmental conscious Australian process industries.Read moreRead less
Hydrodynamics of Bubble Column Reactors. This project will study the hydrodynamics of bubble columns with the aim of optimising these reactors for offshore gas-to-liquid plants. Along with experiments using the state-of-art techniques such as the particle image velocimetry, radioactive particle tracking, electrical capacitance tomography and optical probes, computational fluid dynamics simulations will be conducted to gain a deeper insight into bubble-induced turbulence and regime transitions in ....Hydrodynamics of Bubble Column Reactors. This project will study the hydrodynamics of bubble columns with the aim of optimising these reactors for offshore gas-to-liquid plants. Along with experiments using the state-of-art techniques such as the particle image velocimetry, radioactive particle tracking, electrical capacitance tomography and optical probes, computational fluid dynamics simulations will be conducted to gain a deeper insight into bubble-induced turbulence and regime transitions in these reactors. This information will then be used to devise scale-up strategies of these complex and industrially important equipment.Read moreRead less
Flow process and visible-light driven reactions for polymer manufacturing. This project aims to develop rapid, scalable light-driven continuous flow processing techniques that allow the production of value-added synthetic polymers that cannot be achieved by existing technologies. The project will take advantage of the spatio-temporal control of the light mediated polymerisation with flow process to achieve control over the primary structure, the sequential arrangement of monomer units in a polym ....Flow process and visible-light driven reactions for polymer manufacturing. This project aims to develop rapid, scalable light-driven continuous flow processing techniques that allow the production of value-added synthetic polymers that cannot be achieved by existing technologies. The project will take advantage of the spatio-temporal control of the light mediated polymerisation with flow process to achieve control over the primary structure, the sequential arrangement of monomer units in a polymer chain and the molecular weight distribution. The project will result in the preparation of functional polymers containing a specific arrangement of monomers in the polymer chain and a precise distribution of polymer chains. The development of such process will result in the development of advanced materials.Read moreRead less
Micro Process Plants - Non-Newtonian flow and particle synthesis in confined geometries. Understanding the flow behaviour of well characterised non-Newtonian fluids within microfluidic and nanofluidic devices is of vital importance to development of novel high-value added services, products and devices within Australia's burgeoning biotechnology, environmental technology, communications and information technology industries. The outcomes of this project will provide new 'systematic' design stand ....Micro Process Plants - Non-Newtonian flow and particle synthesis in confined geometries. Understanding the flow behaviour of well characterised non-Newtonian fluids within microfluidic and nanofluidic devices is of vital importance to development of novel high-value added services, products and devices within Australia's burgeoning biotechnology, environmental technology, communications and information technology industries. The outcomes of this project will provide new 'systematic' design standards for microdevice manufacture for these industries, ultimately leading to the creation of new, exciting avenues for tailoring novel biotechnology and 'point-of-care' products for Australia.Read moreRead less
Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would p ....Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would play an important role in preventing avian influenza outbreaks, which are currently affecting both developed and developing countries, costing millions of dollars due to the death and culling of infected poultry.Read moreRead less
Multi-Scale, Multi-Form Approach to the Modelling, Design and Control of Complex Particulate Processes. Many particulate processes suffer from high recycle rates and instability due to lack of knowledge at various scale levels, and on the fitness between model forms and applications. This project will develop a complete model hierarchy ranging from the microscopic scale to full plant scale using a multi-scale, multi-form approach. The joint force of two world class teams will tackle the complex ....Multi-Scale, Multi-Form Approach to the Modelling, Design and Control of Complex Particulate Processes. Many particulate processes suffer from high recycle rates and instability due to lack of knowledge at various scale levels, and on the fitness between model forms and applications. This project will develop a complete model hierarchy ranging from the microscopic scale to full plant scale using a multi-scale, multi-form approach. The joint force of two world class teams will tackle the complex interaction problems covering granulation fundamentals, dynamic modelling, process design and advanced control. The work will lead to significantly improved productivity and quality for a wide range of industrial particulate processes using innovative design and model based control strategies.Read moreRead less
Influence of adsorbed surfactants on three phase contact line motion at high capillary number. The interaction between thin films and solid surfaces underpins the performance of a number of value-adding industrial processes, most notably metallurgical coating operations. Typically, these operations are performed at speeds well beyond the range of existing models, thereby limiting their value when changes in operation occur or when there are problems with product quality. Existing models are also ....Influence of adsorbed surfactants on three phase contact line motion at high capillary number. The interaction between thin films and solid surfaces underpins the performance of a number of value-adding industrial processes, most notably metallurgical coating operations. Typically, these operations are performed at speeds well beyond the range of existing models, thereby limiting their value when changes in operation occur or when there are problems with product quality. Existing models are also limited by their inability to account for the presence of surfactants commonly used throughout industry. This study will produce a capability for predicting how velocity and local changes in molecular composition affect the wetting/dewetting of coated surfaces.Read moreRead less
Bioanalytical Microchips Based on Integrated, Application Tailored Monolithic Modules. Microfluidic devices offer substantial advantages over current technology, in terms of speed, cost of analysis, portability, operator simplicity and safety. Integrating multiple analytical processes within a simple and reliable portable device will lead to application in a range of areas, from pharmacology to therapeutic drug monitoring, proteomic and metabolomic screening for disease diagnosis and drug develo ....Bioanalytical Microchips Based on Integrated, Application Tailored Monolithic Modules. Microfluidic devices offer substantial advantages over current technology, in terms of speed, cost of analysis, portability, operator simplicity and safety. Integrating multiple analytical processes within a simple and reliable portable device will lead to application in a range of areas, from pharmacology to therapeutic drug monitoring, proteomic and metabolomic screening for disease diagnosis and drug development, and also for performing clinical diagnostics in a rural area. This will significantly impact on the quality of life of the Nation as a whole, not only due to expedient diagnosis and treatment which has obvious health benefits, but also in the considerable financial benefits that result from early and efficient treatment. Read moreRead less