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Novel tractography-guided MRI methods for studying healthy brain ageing. Advances in imaging, and particularly Magnetic Resonance Imaging, have opened a new era in the study of the brain enabling a myriad of neuroscience discoveries. This project aims to develop new analysis methods to study and understand the variability in the human brain during ageing, exploiting the wealth of information contained in the so-called tractogram, a mapping of the brain’s wiring. This project expects to develop i ....Novel tractography-guided MRI methods for studying healthy brain ageing. Advances in imaging, and particularly Magnetic Resonance Imaging, have opened a new era in the study of the brain enabling a myriad of neuroscience discoveries. This project aims to develop new analysis methods to study and understand the variability in the human brain during ageing, exploiting the wealth of information contained in the so-called tractogram, a mapping of the brain’s wiring. This project expects to develop innovative imaging biomarkers to characterise the brain changes in the course of healthy brain ageing. Expected outcomes include novel imaging tools for neuroscience, which should allow us to map trajectories of normative healthy brain ageing and use them to identify lifestyle factors that impact these trajectories.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100029
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
High Resolution PET-CT for Small Animal Molecular and Anatomical Imaging. This project will integrate a next generation small animal PET-CT instrument into the Sydney Imaging multi-modality imaging ecosystem. PET-CT enables the investigation of molecular function and anatomical structure in complex living organisms. This platform will enable research as diverse as the development and in-vivo characterisation of new chemical probes and nanoparticles that bind to specific protein targets in the bo ....High Resolution PET-CT for Small Animal Molecular and Anatomical Imaging. This project will integrate a next generation small animal PET-CT instrument into the Sydney Imaging multi-modality imaging ecosystem. PET-CT enables the investigation of molecular function and anatomical structure in complex living organisms. This platform will enable research as diverse as the development and in-vivo characterisation of new chemical probes and nanoparticles that bind to specific protein targets in the body, investigating mechanisms of brain plasticity in predictive learning, understanding the molecular pathways involved in neurodegeneration and cancer, developing novel methods for multi-modal image analysis, and developing and validating new radiation detectors for the next generation of imaging technology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100789
Funder
Australian Research Council
Funding Amount
$397,613.00
Summary
Photo-thermal ammonia decomposition . This project aims to develop of novel catalysts targeted to utilise light and heat for the photo-thermal decomposition of ammonia to produce hydrogen and generate new understanding on the role of light in thermal catalytic reactions. The emergence of the hydrogen economy has resulted in the urgent need for safe and efficient hydrogen transport and storage vectors. Ammonia, a hydrogen carrier, is being increasingly considered as a potential key to facilitate ....Photo-thermal ammonia decomposition . This project aims to develop of novel catalysts targeted to utilise light and heat for the photo-thermal decomposition of ammonia to produce hydrogen and generate new understanding on the role of light in thermal catalytic reactions. The emergence of the hydrogen economy has resulted in the urgent need for safe and efficient hydrogen transport and storage vectors. Ammonia, a hydrogen carrier, is being increasingly considered as a potential key to facilitate the hydrogen economy due to its relative ease of storage. The development of catalysts tailored toward capturing light for ammonia decomposition will enable a new potential pathway for the hydrogen economy, with ammonia as a hydrogen vector. Read moreRead less
The neural bases of decision-making. The aim of this project is to understand the brain circuits controlling voluntary or goal-directed actions and particularly the memory processes that contribute to such actions. Goal-directed action is a fundamental capacity necessary for normal decision-making that is significantly attenuated by normal aging. This project aims to establish the neural circuits engaged in encoding new goal-directed actions, how this encoding is accomplished without interfering ....The neural bases of decision-making. The aim of this project is to understand the brain circuits controlling voluntary or goal-directed actions and particularly the memory processes that contribute to such actions. Goal-directed action is a fundamental capacity necessary for normal decision-making that is significantly attenuated by normal aging. This project aims to establish the neural circuits engaged in encoding new goal-directed actions, how this encoding is accomplished without interfering with pre-existing memories and how these memories are later retrieved to guide planning and performance. Understanding the determinants of such actions will enable the development of novel ways to treat ageing-related deficits in decision-making with significant economic benefits. Read moreRead less
Integrative brain imaging technologies. This project aims to develop quantitative metabolic imaging using simultaneous magnetic resonance imaging (MRI) and positron emission tomography (PET). The current generation of MR-PET scanners are capable of simultaneously acquiring MRI and PET data to enable quantitative anatomical, physiological and metabolic imaging. The project aims to develop new MRI methods for quantitative anatomical mapping, MR-based motion correction of dynamic PET scan data, and ....Integrative brain imaging technologies. This project aims to develop quantitative metabolic imaging using simultaneous magnetic resonance imaging (MRI) and positron emission tomography (PET). The current generation of MR-PET scanners are capable of simultaneously acquiring MRI and PET data to enable quantitative anatomical, physiological and metabolic imaging. The project aims to develop new MRI methods for quantitative anatomical mapping, MR-based motion correction of dynamic PET scan data, and joint estimation of physiological and metabolic organ activity. These advances will create innovative imaging technologies for advanced biomedical imaging research with a particular emphasis in healthy ageing.
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Three-dimensional solar-energy-driven hydrogen generation from ammonia. This project aims to address the challenges of hydrogen generation, transportation and storage by conceptualising a novel three-dimensional, solar-driven system for ammonia splitting on ultralight catalyst materials. The project expects to generate new knowledge in the area of advanced materials enabled hydrogen technologies through interdisciplinary approaches involving materials science, novel catalysis, and nanotechnology ....Three-dimensional solar-energy-driven hydrogen generation from ammonia. This project aims to address the challenges of hydrogen generation, transportation and storage by conceptualising a novel three-dimensional, solar-driven system for ammonia splitting on ultralight catalyst materials. The project expects to generate new knowledge in the area of advanced materials enabled hydrogen technologies through interdisciplinary approaches involving materials science, novel catalysis, and nanotechnology. Expected outcomes include new catalyst materials, design strategies, and advanced ammonia splitting technologies. This should provide significant benefits, such as newly created knowledge, technological innovation, research training, contributing to hydrogen economy and net zero for a greener environment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101272
Funder
Australian Research Council
Funding Amount
$420,885.00
Summary
Glial Plasticity: How experience and aging change brain structure. 50 % of the cells in the brain are called glia. These cells work with neurons to regulate how we think, feel and behave. Most glial cells are added to the brain after birth, however we know very little about how this process works, or how it may be changed by lived-experience. The overarching aim of this study is to better understand how lived-experience impacts the growth of the major types of glial cells in the brain. To do th ....Glial Plasticity: How experience and aging change brain structure. 50 % of the cells in the brain are called glia. These cells work with neurons to regulate how we think, feel and behave. Most glial cells are added to the brain after birth, however we know very little about how this process works, or how it may be changed by lived-experience. The overarching aim of this study is to better understand how lived-experience impacts the growth of the major types of glial cells in the brain. To do this, I will use cutting-edge technologies and identify; 1) the rates of cell growth for the major types of glia, and 2) map how they are integrated into the brain. This will lead to important new information on how lived-experience can shape the growth and structure of the brain.Read moreRead less
Phenotyping doublecortin+ cells to unravel human adult neurogenesis. This project investigates one of the brain’s most remarkable phenomena: adult neurogenesis, the birth of new brain cells in a specialised brain area (the hippocampus) occurring well into adulthood. This process contributes to many species’ capacity to learn, remember and regenerate. However whether this process occurs in humans is heavily debated. Using new neuroscience tools, this project will produce new insights into human a ....Phenotyping doublecortin+ cells to unravel human adult neurogenesis. This project investigates one of the brain’s most remarkable phenomena: adult neurogenesis, the birth of new brain cells in a specialised brain area (the hippocampus) occurring well into adulthood. This process contributes to many species’ capacity to learn, remember and regenerate. However whether this process occurs in humans is heavily debated. Using new neuroscience tools, this project will produce new insights into human adult neurogenesis by deeply examining hippocampal cells that express the newborn cell marker, doublecortin. This will enable clarification of the existence and extent of adult neurogenesis in humans, and provide the foundation to leverage this process for improving learning, memory and brain regeneration in people.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100269
Funder
Australian Research Council
Funding Amount
$422,232.00
Summary
Mapping the neural circuits which control water and salt intake. This project aims to map the brain circuits controlling fluid and salt intake using innovative genetically encoded techniques, which enable precise targeting and manipulation of select neuronal populations. Expected outcomes of this project include constructing detailed maps of the brain circuits for fluid and salt intake by tracing multiple nodes in the network, characterising neuronal populations, and precisely defining their fun ....Mapping the neural circuits which control water and salt intake. This project aims to map the brain circuits controlling fluid and salt intake using innovative genetically encoded techniques, which enable precise targeting and manipulation of select neuronal populations. Expected outcomes of this project include constructing detailed maps of the brain circuits for fluid and salt intake by tracing multiple nodes in the network, characterising neuronal populations, and precisely defining their functions. This should provide significant benefits including understanding the brain regions controlling fluid and salt intake which are essential for maintaining fluid homeostasis, and providing a framework for investigating the neural circuits underlying other complex behaviours.Read moreRead less
Charging transition metals with activating alkanes. The project aims to engineer positively charged metal complexes and use them to explore the chemistry of bound activated alkane ligands. The transformation of cheap, plentiful alkanes into more valuable products is a major quest in chemistry, and complexes of alkanes bound to metals are expected to play a key role in transformations of alkanes. The project intends to use the activated metal bound alkane to transform the normally inert alkane in ....Charging transition metals with activating alkanes. The project aims to engineer positively charged metal complexes and use them to explore the chemistry of bound activated alkane ligands. The transformation of cheap, plentiful alkanes into more valuable products is a major quest in chemistry, and complexes of alkanes bound to metals are expected to play a key role in transformations of alkanes. The project intends to use the activated metal bound alkane to transform the normally inert alkane into compounds with desirable functional groups. This should make the synthesis of alkane complexes stable at room temperature in solution a realistic possibility. These cheap, plentiful alkanes can be turned into more valuable products, bringing benefits to industry.Read moreRead less