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Deprescribing In Frail Older People: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$269,235.00
Summary
Frail older people are often prescribed unnecessary medications. We will test whether stopping some of their medication improves longevity, sleep quality and independence and reduces confusion and falls. We will stop medication that does not provide any overall benefit or is thought to be harmful in older people. We will monitor our volunteers frequently for adverse effects and re-start their medicines if necessary. We hope to show that it is safe to stop many medications in frail older people.
Statistical Approaches For Studying The Safety And Effectiveness Of Medicines
Funder
National Health and Medical Research Council
Funding Amount
$307,946.00
Summary
When medicines first reach the market many of the potential adverse reactions are unknown. Clinical trials of medicines often exclude elderly patients and patients with multiple chronic diseases who are at higher risk of adverse drug reactions. This research aims to improve medicine safety by developing statistical methods to detect and validate medication safety signals and to identify patients who are at high risk of adverse reactions to medicines.
Investigation Of Small Molecule Interactions With The Human Leukocyte Antigen And Their Role In Non-infectious Disease
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The Human Leukocyte Antigens (HLA) play a key role in the immune system helping the body differentiate healthy from diseased cells. Numerous autoimmune diseases and adverse drug reactions are associated with specific HLA variants. This study seeks to unlock the mechanisms behind these diseases, investigating how small molecules including drugs interact with the HLA to make healthy body cells seem foreign. This research has the potential to inform strategies for disease avoidance and management.
Improving Nurse-administered Sedation Practice In The Cardiac Catheterisation Laboratory
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
This research will provide evidence to inform nursing management of the potentially life-threatening complications that are associated with the administration of sedation in the cardiac catheterisation laboratory. Three studies will be conducted: an investigation of the prevalence and risk factors of hypothermia after sedation; a randomised controlled trial of active warming to prevent hypothermia; and a study to determine whether audit and feedback improves patient safety during sedation.
Real-time Surveillance For The Early Detection Of E-health Related Adverse Events
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Health care delivery has become increasingly dependent on information technology. There is growing concern about the risk of harm caused by e-health technology. Current methods for error detection are minimal, and healthcare software remains largely unregulated. This research aims to develop innovative surveillance technologies to provide real-time monitoring and to facilitate early detection of e-health generated adverse events, as a critical step to improve the safety of e-health technology.
Early Antipsychotic Exposure During Childhood And Adolescence: Does It Lead To Long Term Brain And Behaviour Changes In Adulthood?
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Mental health problems affect at least 9% of Australia's 4.1 million children. With the trend towards prescribing antipsychotic medication “off-label” to control these mental disorders in young people and the long-term consequences of doing so unknown, this timely research program aims to address a critical health issue by providing clinicians with valuable information so they can better balance the risk/benefit ratio before prescribing antipsychotics to young people.
Analysis Of The Apoptotic And Therapeutic Effects Of Histone Deacetylase Inhibitors On Multiple Myeloma
Funder
National Health and Medical Research Council
Funding Amount
$287,321.00
Summary
Multiple myeloma (MM) is an incurable progressive cancer of plasma cells within blood. It is the second most common blood cancer and represents 2% of all cancer-related deaths. Statistics show increasing incidence and decreasing age of onset. The cause and progression of MM is poorly understood and current treatments are frequently followed by relapse. This project will assess exciting new therapies against the survival of MM cells leading to more effective treatments in the future.