The human mirror system and the perception of others' actions. This research will provide greater understanding of how the human mirror system operates for the perception of actions, a crucial first-step toward understanding disorders of action perception such as autism and apraxia. The research program will also contribute greatly to building national capacity in cognitive neuroscience research, using advanced brain imaging methods. The fellow actively encourages and mentors young scientists, o ....The human mirror system and the perception of others' actions. This research will provide greater understanding of how the human mirror system operates for the perception of actions, a crucial first-step toward understanding disorders of action perception such as autism and apraxia. The research program will also contribute greatly to building national capacity in cognitive neuroscience research, using advanced brain imaging methods. The fellow actively encourages and mentors young scientists, organises advanced workshops that bring brain imaging researchers around the world to Australia, and builds international collaborations based around high-field brain imaging. The Future Fellowship will substantially enhance these activities, building capacity and enhancing Australia's reputation in cognitive neurosciences.Read moreRead less
The implications of resistance training for the control of movement. Resistance training (or weight lifting) is an essential element of comprehensive rehabilitation programs in a wide range of clinical settings. However, because we know little about how the organization of the nervous system is affected by training with high loads, the consequences of resistance training for our ability to control functional movements are unclear. The ultimate goal of this research is to generate basic knowledge ....The implications of resistance training for the control of movement. Resistance training (or weight lifting) is an essential element of comprehensive rehabilitation programs in a wide range of clinical settings. However, because we know little about how the organization of the nervous system is affected by training with high loads, the consequences of resistance training for our ability to control functional movements are unclear. The ultimate goal of this research is to generate basic knowledge about the impact of resistance training on nervous system function. The research will lead to the design of injury prevention and rehabilitation programs that are maximally effective, and provide a genuine benefit to the community.Read moreRead less
Platform technology to decode motor control through ultra high-field MRI. This project aims to advance our understanding of the poorly understood neural circuits that enable fine motor control in humans. To obtain this knowledge, new platform technology will be developed to capture the full kinematics of the hand during concurrent functional magnetic resonance imaging at ultra high-field. This device will allow testing of fundamental theories describing the canonical microcircuits involved in ha ....Platform technology to decode motor control through ultra high-field MRI. This project aims to advance our understanding of the poorly understood neural circuits that enable fine motor control in humans. To obtain this knowledge, new platform technology will be developed to capture the full kinematics of the hand during concurrent functional magnetic resonance imaging at ultra high-field. This device will allow testing of fundamental theories describing the canonical microcircuits involved in hand motion. Expected outcomes include new evidence of mirror neurons and observation of predictive error signals in the motor cortex. This new knowledge paves the way towards improved computer-brain interface technology which is likely to create benefits through translation to applications such as artificial limb control.Read moreRead less
A common sub-cortical system for human eye and limb control. This project aims to discover how the human brain controls reaching movements via structures and control mechanisms used for rapid eye movements, and for prey capture by lower vertebrates such as fish. Fast and accurate visually-guided movement was crucial for survival long before animals evolved a cerebral cortex, suggesting that basic control systems may be conserved across species. The notion that primitive sub-cortical systems can ....A common sub-cortical system for human eye and limb control. This project aims to discover how the human brain controls reaching movements via structures and control mechanisms used for rapid eye movements, and for prey capture by lower vertebrates such as fish. Fast and accurate visually-guided movement was crucial for survival long before animals evolved a cerebral cortex, suggesting that basic control systems may be conserved across species. The notion that primitive sub-cortical systems can control complex, human limb movements challenges conventional thinking about movement-related brain activity, and has important implications for the design of human-machine interfaces and training protocols in rehabilitation, industry and sport.Read moreRead less
Towards direct imaging of neuronal currents with MRI. This project aims to develop novel neuronal current magnetic resonance imaging (nc-MRI) methods that harness the oscillatory behaviour of neuronal magnetic fields. Current methods of detecting neuronal activity in the living human brain have limited spatial and temporal resolution. Use of nc-MRI aims to overcome these limitations by imaging the effects on the MRI signal of small transient magnetic fields associated with neuronal activity. Sig ....Towards direct imaging of neuronal currents with MRI. This project aims to develop novel neuronal current magnetic resonance imaging (nc-MRI) methods that harness the oscillatory behaviour of neuronal magnetic fields. Current methods of detecting neuronal activity in the living human brain have limited spatial and temporal resolution. Use of nc-MRI aims to overcome these limitations by imaging the effects on the MRI signal of small transient magnetic fields associated with neuronal activity. Signal-to-noise ratio is at the limits of detectability using current imaging systems and nc-MRI is yet to be convincingly demonstrated. An integrated framework for simulating nc-MRI in the visual cortex is expected to be developed.Read moreRead less
The role of synapse development in cognitive disorder. In humans, intellectual disability occurs when nerve cells in the brain fail to connect. The project examines fundamental molecular processes involved in synapse development of neurons. The use of insect models provides a generalised biological template to understand how synaptic molecules contribute to behaviours that underlie cognitive disorder.
Competing demands on the axial muscles: Effects, consequences, compensations and mechanisms. Back and neck pain are major health issues and are associated with considerable cost to society and an individual's quality of life. A major issue is to identify factors that increase the chance of developing pain. This project will investigate a novel and innovative possibility; that competition between the many functions of the trunk muscles may increase the possibility for injury. We will study how th ....Competing demands on the axial muscles: Effects, consequences, compensations and mechanisms. Back and neck pain are major health issues and are associated with considerable cost to society and an individual's quality of life. A major issue is to identify factors that increase the chance of developing pain. This project will investigate a novel and innovative possibility; that competition between the many functions of the trunk muscles may increase the possibility for injury. We will study how the nervous system coordinates functions as diverse and movement of the spine, breathing, and control of head and eye movement. A key issue will be to identify whether situations arise in which control of the spine is compromised, potentially leading to increased risk of pain and injury. Such data can aid prevention and rehabilitation.Read moreRead less
Control of cellular differentiation in the developing brain. This project aims to understand how mature brain cells form during foetal life. The central hypothesis is that a specific transcription factor family, called NFI, regulates the epigenetic state of the cell, allowing chromatin accessibility and subsequent transcriptional activation and repression to control cellular differentiation. Aims 1 and 2 will investigate how brain cells transition from proliferating progenitor cells to different ....Control of cellular differentiation in the developing brain. This project aims to understand how mature brain cells form during foetal life. The central hypothesis is that a specific transcription factor family, called NFI, regulates the epigenetic state of the cell, allowing chromatin accessibility and subsequent transcriptional activation and repression to control cellular differentiation. Aims 1 and 2 will investigate how brain cells transition from proliferating progenitor cells to differentiated mature cell types. Aim 3 will investigate how differentiation is maintained in the adult brain. Methods used involve genome and chromatin analyses of cells isolated from transgenic mouse models. Outcomes and benefits are substantial knowledge gain applicable to stem cell regulation and brain health.Read moreRead less
Transcriptional control of neural stem cell differentiation during development and disease. Understanding the molecular mechanisms that control how neural stem cells differentiate is critical to provide potential therapeutic treatment for neurodegenerative diseases and for brain cancer. This project will aim to discover, using an animal model system, the genes and molecules regulating these key biological processes.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100074
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
Facilities for automated high-throughput slide scanning and stereology. The equipment requested will facilitate the work of the Australian Mouse Brain Mapping Consortium, a consortium of Australian research groups collaborating to provide the only mouse model brain mapping capability in the country. The consortium brings together laboratory, neuroimaging and computational expertise in a comprehensive framework for imaging the mouse brain. This will help researchers to study mouse models of genet ....Facilities for automated high-throughput slide scanning and stereology. The equipment requested will facilitate the work of the Australian Mouse Brain Mapping Consortium, a consortium of Australian research groups collaborating to provide the only mouse model brain mapping capability in the country. The consortium brings together laboratory, neuroimaging and computational expertise in a comprehensive framework for imaging the mouse brain. This will help researchers to study mouse models of genetic and acquired disorders across the life-span. Remote viewing and analysis capabilities will help overcome the 'tyranny of distance', increasing national access to the facility. Repositories of digitised images will increase the availability of valuable research material to other Australian and international researchers.Read moreRead less