The role of synapse development in cognitive disorder. In humans, intellectual disability occurs when nerve cells in the brain fail to connect. The project examines fundamental molecular processes involved in synapse development of neurons. The use of insect models provides a generalised biological template to understand how synaptic molecules contribute to behaviours that underlie cognitive disorder.
Co-design and dynamic mission optimisation of hypersonic flight vehicles. This project aims to deliver fundamental knowledge by integrating the modelling and control with the design of next generation hypersonic platforms. In an era where Australia's national security reliance on geographic isolation and support from allied forces are being challenged, the research outcomes of this project will play an important role in understanding the capabilities of hypersonic systems. The project will also ....Co-design and dynamic mission optimisation of hypersonic flight vehicles. This project aims to deliver fundamental knowledge by integrating the modelling and control with the design of next generation hypersonic platforms. In an era where Australia's national security reliance on geographic isolation and support from allied forces are being challenged, the research outcomes of this project will play an important role in understanding the capabilities of hypersonic systems. The project will also have significant spillover benefits into other complex system domains, where computational tools can be used to aid in design leading to high embedded-IP products for Australian industry. Furthermore, the proposal encompasses a strong research training aspect, with graduates exposed to leading edge industry and academia.Read moreRead less
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101075
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Novel immune cell subsets in the centre nervous system and supporting tissues. This project aims to identify and characterise novel resident immune cell subsets within the brain and retina, and their close supporting tissues. The project expects to generate new knowledge in the areas of neuroimmunology and ocular immunology by using molecular and cellular techniques to examine the diversity of immune cells within the brain and retina. It is expected that the project will advance our understandin ....Novel immune cell subsets in the centre nervous system and supporting tissues. This project aims to identify and characterise novel resident immune cell subsets within the brain and retina, and their close supporting tissues. The project expects to generate new knowledge in the areas of neuroimmunology and ocular immunology by using molecular and cellular techniques to examine the diversity of immune cells within the brain and retina. It is expected that the project will advance our understanding of the biological mechanisms that protect the central nervous system from harmful inflammation and thus improve our knowledge of the immunobiology of the brain and eye.Read moreRead less
Variable Structure Control Systems in Networked Environments. This project will be the first in the world to lay the foundation for a new theory for understanding and designing new variable structure control systems in the networked environments, which is in great need due to increasing use of shared communication networks in modern industrial systems. It will firmly place Australia at the forefront of this research by developing a cutting edge technology for improving reliability and efficiency ....Variable Structure Control Systems in Networked Environments. This project will be the first in the world to lay the foundation for a new theory for understanding and designing new variable structure control systems in the networked environments, which is in great need due to increasing use of shared communication networks in modern industrial systems. It will firmly place Australia at the forefront of this research by developing a cutting edge technology for improving reliability and efficiency of industrial variable structure control systems in the networked environments, hence resulting in cost-saving and improved productivity for industry. It will provide training for new leading researchers specialised in this new theory and technology.Read moreRead less
The social determinants of childhood injury. Child hood injury is a preventable problem of major importance. This project will provide a comprehensive, research-based policy solution that will minimise death and disability among children zero to three years of age.
Neural circuit control of effort under stress . This Project aims to investigate how the ‘decision’ to persist in exerting effort to obtain a reward is encoded in the the brain and affected by stress. This work will generate new knowledge on the neural mechanisms through which stress modifies neural activity to control decision making processes underpinning adaptive behaviours essential for survival. The expected outcomes of this work include enhanced capacity at the interface of behavioural a ....Neural circuit control of effort under stress . This Project aims to investigate how the ‘decision’ to persist in exerting effort to obtain a reward is encoded in the the brain and affected by stress. This work will generate new knowledge on the neural mechanisms through which stress modifies neural activity to control decision making processes underpinning adaptive behaviours essential for survival. The expected outcomes of this work include enhanced capacity at the interface of behavioural and computational neuroscience, that will in turn provide significant benefits through greater insight into brain functions essential for survival, with long ranging implications for performance optimisation and brain-inspired computing. Read moreRead less
How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understandi ....How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understanding the dynamics of developmental systems that shape complex brain traits includes establishing new developmental paradigms in evolutionary theory, generating new tools to investigate and manipulate brain gene expression in vivo, and the potential discovery of the causes of neurodevelopmental dysfunction.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668246
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Advanced Cell Labelling and Imaging Facility. Understanding the genetic regulation of cellular processes such as migration, differentiation and growth is an important frontier technology with significant biomedical potential. The Australian community is facing an increasing need to provide solutions for a variety of human diseases and disorders, including birth defects, nervous system injury and stroke, and ageing-related conditions. The proposed facility will allow researchers to test in vivo g ....Advanced Cell Labelling and Imaging Facility. Understanding the genetic regulation of cellular processes such as migration, differentiation and growth is an important frontier technology with significant biomedical potential. The Australian community is facing an increasing need to provide solutions for a variety of human diseases and disorders, including birth defects, nervous system injury and stroke, and ageing-related conditions. The proposed facility will allow researchers to test in vivo gene/pharmaceutical therapies as well as to better understand the genetic regulation of normal cellular processes. Read moreRead less
Investigating the role of the innate immune complement system in the abnormal development of the central nervous system. Past research has discovered a surprising link between the immune system, dietary folate deficiency and the development of the embryonic brain. This project will investigate the immune system in the developing brain, in order to understand the causes of developmental defects such as neural tube defects, and the role dietary folate plays in this process.