Symmetries in CR-geometry. This project aims at investigating symmetries of geometric objects called CR-manifolds. It is expected to open new avenues for understanding such symmetries at the infinitesimal level and lead to ground-breaking results in CR-geometry. Expected outcomes include new methodology, solving long-standing problems, and establishing international research collaborations. The benefits are in enhancing the strength of the research in analysis and geometry performed in Australia ....Symmetries in CR-geometry. This project aims at investigating symmetries of geometric objects called CR-manifolds. It is expected to open new avenues for understanding such symmetries at the infinitesimal level and lead to ground-breaking results in CR-geometry. Expected outcomes include new methodology, solving long-standing problems, and establishing international research collaborations. The benefits are in enhancing the strength of the research in analysis and geometry performed in Australia, in fostering the international competitiveness of Australian research and in high-quality research training.Read moreRead less
Nilpotent associative algebras and spherical hypersurfaces. This project concerns pure basic research in mathematics and is based on an important recently discovered relationship between certain geometric and algebraic objects. In the project, this relationship will be applied in a novel way to solve several significant long-standing problems in the research area of complex geometry.
The Reconstruction and Recognition Problems for Hypersurface Singularities. This project concerns pure basic research in mathematics. It is centred around a surprising relationship between geometric objects called quasi-homogeneous isolated hypersurface singularities, and algebraic structures described as Artinian Gorenstein algebras. This relationship has not been fully understood despite numerous attempts by internationally based experts to shed light on it. Armed with a novel approach to Arti ....The Reconstruction and Recognition Problems for Hypersurface Singularities. This project concerns pure basic research in mathematics. It is centred around a surprising relationship between geometric objects called quasi-homogeneous isolated hypersurface singularities, and algebraic structures described as Artinian Gorenstein algebras. This relationship has not been fully understood despite numerous attempts by internationally based experts to shed light on it. Armed with a novel approach to Artinian Gorenstein algebras, this project proposes to clarify the nature of this relationship and utilise it for solving related geometric and algebraic problems. In particular, it aims at obtaining a groundbreaking result in the area of classical invariant theory.Read moreRead less
Proper Group Actions in Complex Geometry. The results of the project will enhance Australia's performance in several key mathematical areas as well as mathematical applications to physics critical for expanding Australia's knowledge base and research capability. The project has strong international aspects, it will foster the international competitiveness of Australian research and establish long-term collaborations between Australian researchers and high profile world experts in the area of the ....Proper Group Actions in Complex Geometry. The results of the project will enhance Australia's performance in several key mathematical areas as well as mathematical applications to physics critical for expanding Australia's knowledge base and research capability. The project has strong international aspects, it will foster the international competitiveness of Australian research and establish long-term collaborations between Australian researchers and high profile world experts in the area of the proposal. It will create an opportunity for a Ph.D. graduate to be involved in top-class research as a Research Associate, and will attract Ph.D. and honours students thus enabling research training in a high-quality mathematical environment.Read moreRead less
Symmetry and geometric structures. This is a fundamental research project in mathematics, especially concerned with the interaction between symmetry, differential equations, and geometry. Based on many classical and recently discovered instances, the aim of the project is to use symmetries to build and understand curved geometric structures from their flat counterparts.
The Role Of Melanoma Tumour Antigen P97 (Melanotransferrin) In Melanoma Tumourigenesis.
Funder
National Health and Medical Research Council
Funding Amount
$563,242.00
Summary
The Role of Melanoma Tumour Antigen p97 (Melanotransferrin) in Melanoma Tumourigenesis Melanotransferrin (MTf) is a homologue of the iron transport protein, transferrin, and was one of the first well characterised melanoma tumour antigens. Our published studies have shown that MTf plays an important role in melanoma tumourigenesis in vivo. In this proposal, we will assess if it is associated with melanoma progression in patient samples and examine its role in melanoma growth and metastasis.
Investigating The Cellular Response To Iron-Depletion: The Trilogy Of ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$552,572.00
Summary
Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for t ....Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.Read moreRead less
Improving neuronal cell function with cell permeable copper complexes. Metal-based drugs offer an exciting new approach to treatment of neurodegeneration. However, little is known about how cells metabolise these drugs and this information is critical for further drug development. This project will determine how metal-based drugs are metabolised by neuronal cells and how this may result in therapeutic benefit.
Electrical properties of human dendrites. This project aims to determine the electrical properties of dendrites in human neurons. Dendrites are the primary site of synaptic input to neurons and their electrical properties play a key role in information processing in the brain. While we know much about the electrical properties of dendrites in other species, primarily rodents, little is known about the electrical properties of human dendrites. This project aims to address this gap in knowledge fo ....Electrical properties of human dendrites. This project aims to determine the electrical properties of dendrites in human neurons. Dendrites are the primary site of synaptic input to neurons and their electrical properties play a key role in information processing in the brain. While we know much about the electrical properties of dendrites in other species, primarily rodents, little is known about the electrical properties of human dendrites. This project aims to address this gap in knowledge for the first time. The results obtained will shed light on the mechanisms the brain uses to process information, and therefore will bring us a step closer to truly understanding ourselves.Read moreRead less
Tailoring cellulose properties by manipulating cellulose synthase. Cellulose, a highly abundant polymer produced by plants, has many existing uses in Australian fibre and polymer industries and potential uses as, for example, an abundant feedstuff for biomass conversion into ethanol and other high value products. The optimal properties for different applications vary so that, for example, high crystallinity cellulose gives strong fibres whereas low crystallinity cellulose dissolves in gentler so ....Tailoring cellulose properties by manipulating cellulose synthase. Cellulose, a highly abundant polymer produced by plants, has many existing uses in Australian fibre and polymer industries and potential uses as, for example, an abundant feedstuff for biomass conversion into ethanol and other high value products. The optimal properties for different applications vary so that, for example, high crystallinity cellulose gives strong fibres whereas low crystallinity cellulose dissolves in gentler solvents on the way to producing cellulose-based polymers. By exploring ways to adjust the properties of celluloses for use in different applications, we can deliver potential benefits to primary producers, industries and the environment.
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