New guardians of the mucosa: Molecular characterisation of M cell biology. We aim to completely define the cellular and molecular biology of gut and lung M cells for the first time. We will elucidate how they develop, are regulated and function at a molecular level, and how M cells maintain normal gut and lung tissues and induce immune responses to protect against microbial challenges. In the future, the new insights will be essential pre-requisites for the development of mucosal-based intervent ....New guardians of the mucosa: Molecular characterisation of M cell biology. We aim to completely define the cellular and molecular biology of gut and lung M cells for the first time. We will elucidate how they develop, are regulated and function at a molecular level, and how M cells maintain normal gut and lung tissues and induce immune responses to protect against microbial challenges. In the future, the new insights will be essential pre-requisites for the development of mucosal-based interventions and vaccines that protect the gut and lung from infectious and inflammatory issues. The harnessing of effective immune responses to control such challenges, are of enormous fundamental and long-standing biological interest, and are amongst the most important areas of current scientific research.Read moreRead less
Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic ....Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic substances. Understanding this molecular program of epithelial-immune cell-mediated sensing/repair will be essential to understand how tissue-repair processes can be driven in the lung, an organ critical for respiration and thus life.Read moreRead less
Human Leukocyte Antigen-A and -B regulation of Natural Killer cell function. The aim of this project is to determine how genetic variation in the genes encoding cell surface receptors expressed by innate lymphocytes and the molecules they recognise diversifies their capacity to sense and respond to infection. This knowledge is critical for understanding why there are intrinsic differences between individuals with respect to their capacity to respond to different types of infection and will ultim ....Human Leukocyte Antigen-A and -B regulation of Natural Killer cell function. The aim of this project is to determine how genetic variation in the genes encoding cell surface receptors expressed by innate lymphocytes and the molecules they recognise diversifies their capacity to sense and respond to infection. This knowledge is critical for understanding why there are intrinsic differences between individuals with respect to their capacity to respond to different types of infection and will ultimately inform our capacity to better deploy personalised medicines.Read moreRead less
Early career teacher induction: Supporting precarious teachers. This project aims to investigate the ways in which Australian induction policies support precariously employed early career teachers to effectively manage student classroom behaviour. This project expects to generate new knowledge of workforce development and induction experiences of early career teachers employed on casual and short-term contracts. Expected outcomes of this project include alternative policy and practice recommenda ....Early career teacher induction: Supporting precarious teachers. This project aims to investigate the ways in which Australian induction policies support precariously employed early career teachers to effectively manage student classroom behaviour. This project expects to generate new knowledge of workforce development and induction experiences of early career teachers employed on casual and short-term contracts. Expected outcomes of this project include alternative policy and practice recommendations to support the transition of insecure replacement teachers within the profession. The benefits of this research include, improving teachers’ classroom management practices; the retention of new teachers; improving teacher workforce development; and building a healthier education system. Read moreRead less
Career change teachers: Addressing teacher shortages in Australia . Australia is facing a teacher shortage crisis. Consequently, there have been concerted efforts by governments to attract people into teaching from other sections of the workforce. However, career change teachers often do not stay longer than five years in the profession. There is little evidence on how their retention can be enhanced. This project aims to better understand the differing motivations and experiences of these teach ....Career change teachers: Addressing teacher shortages in Australia . Australia is facing a teacher shortage crisis. Consequently, there have been concerted efforts by governments to attract people into teaching from other sections of the workforce. However, career change teachers often do not stay longer than five years in the profession. There is little evidence on how their retention can be enhanced. This project aims to better understand the differing motivations and experiences of these teachers from diverse backgrounds, and to determine how they can be better prepared and supported through their early years of teaching. A clear benefit of this project will be the longer term success for career change teachers and their schools and will ensure young people are not disadvantaged by high teacher turnover. Read moreRead less
Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cel ....Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cell migration with relevance to the basic biology of inflammation, repair and regeneration and new innovations for cell imaging. Significant benefits are expected to arise from this new knowledge and from advanced skills training and improved national capabilities in bio-imaging and analysis.Read moreRead less
Learning-rich leadership for quality improvement in early education. This project aims to establish Australia's first evidence base to inform quality improvement in early childhood education services through the development of educational leaders. Effective leadership is essential to ensuring the effective implementation of the Australian government's national quality standards for early childhood education. A new theory of 'learning-rich' leadership for quality improvement will be developed to ....Learning-rich leadership for quality improvement in early education. This project aims to establish Australia's first evidence base to inform quality improvement in early childhood education services through the development of educational leaders. Effective leadership is essential to ensuring the effective implementation of the Australian government's national quality standards for early childhood education. A new theory of 'learning-rich' leadership for quality improvement will be developed to influence leadership education in the early childhood sector. Expected outcomes from this project have potential benefits for the increased effectiveness in service quality for early childhood education.Read moreRead less
Shifting the Culture of Out-of-field Professional Education for Teachers. This project aims to model an education system that would diversify the expertise of teachers as part of attending to long-term teacher shortage. It responds to a pressing national need for a system of valued and accessible professional education (PE) for out-of-field teachers. The project draws on perspectives from schools, governments and PE providers to expose current practices, cultural norms, and policies; propose an ....Shifting the Culture of Out-of-field Professional Education for Teachers. This project aims to model an education system that would diversify the expertise of teachers as part of attending to long-term teacher shortage. It responds to a pressing national need for a system of valued and accessible professional education (PE) for out-of-field teachers. The project draws on perspectives from schools, governments and PE providers to expose current practices, cultural norms, and policies; propose an 'ideal' PE ecosystem that values re-specialisation in the core subjects; and develop principles to inform policy and practice needed to attain this ideal. The evidence-based framing of PE will inform efforts by schools, PE providers and policy makers to sustain a highly capable, adaptive and specialised teaching workforce.Read moreRead less
Teacher attraction and retention in hard-to-staff schools. Australia is facing a teacher shortage crisis. Many schools have become ‘hard-to-staff’ – evident through either a lack of teachers or a high teacher turnover. The aim of this project is to provide the foundations for strategies that can be implemented by schools and systems to address this problem. Due to the schools’ locations, these shortages can have severe consequences for already educationally vulnerable young people. This has been ....Teacher attraction and retention in hard-to-staff schools. Australia is facing a teacher shortage crisis. Many schools have become ‘hard-to-staff’ – evident through either a lack of teachers or a high teacher turnover. The aim of this project is to provide the foundations for strategies that can be implemented by schools and systems to address this problem. Due to the schools’ locations, these shortages can have severe consequences for already educationally vulnerable young people. This has been a significant concern of governments nationally and internationally. An important outcome from the project will be how best to attract and retain teachers in hard-to-staff schools. This will have benefits for the teaching profession, young people who attend hard-to-staff schools and the broader community. Read moreRead less