Cellular mechanisms that protect against copper-bound beta-amyloid. This project will investigate some of the brain’s own mechanisms for protecting itself against Alzheimer’s disease. Understanding these mechanisms will be important for developing future therapeutic strategies for treating Alzheimer’s disease.
Old brain cells perform new tricks to allow life-long learning. In the brain, nerve cells transmit electrical signals more quickly and reliably when they are insulated. The insulating cells undergo small adaptive changes that speed up information transfer during learning, and the faster the electrical signal, the better the learning outcomes. This project aims to understand the signals that direct insulating cells to adapt and support life-long learning. In the longer term, this knowledge may be ....Old brain cells perform new tricks to allow life-long learning. In the brain, nerve cells transmit electrical signals more quickly and reliably when they are insulated. The insulating cells undergo small adaptive changes that speed up information transfer during learning, and the faster the electrical signal, the better the learning outcomes. This project aims to understand the signals that direct insulating cells to adapt and support life-long learning. In the longer term, this knowledge may be used to: develop interventions that improve learning and educational outcomes; counteract age-related memory decline and enable longer work force participation; develop strategies to circumvent the memory loss caused by brain diseases, or improve the design of computer hardware.Read moreRead less
Microfluidic technology to help understand physical damage to brain cells. Understanding the organisation, structure and mechanisms of the human brain and nervous system remains one of the biggest challenges of science. This project aims to develop a new cell culture platform to form defined molecular networks of brain cells and to monitor changes throughout the network in response to a small localised injury within the network. This innovative platform will be used to help understand changes wi ....Microfluidic technology to help understand physical damage to brain cells. Understanding the organisation, structure and mechanisms of the human brain and nervous system remains one of the biggest challenges of science. This project aims to develop a new cell culture platform to form defined molecular networks of brain cells and to monitor changes throughout the network in response to a small localised injury within the network. This innovative platform will be used to help understand changes within cells in response to physical damage to networks of brain cells. This is one of the major causes of death and disability in developed nations, and is identified as a risk factor for a range of neurodegenerative diseases including Alzheimer's, Parkinson's and motor neuron disease.Read moreRead less
Talking Maths: Bridging the gap through talk in Early Years mathematics . The study aims to address the gap in mathematical performance in Australia in relation to socioeconomic status (SES) by focusing on language and learning in mathematics. The study will design and evaluate a school-based intervention that positions language through talk as a key resource in teaching mathematics in Grades 1 and 2. Outcomes of the study will be empirical evidence of the effect of a language-based pedagogy on ....Talking Maths: Bridging the gap through talk in Early Years mathematics . The study aims to address the gap in mathematical performance in Australia in relation to socioeconomic status (SES) by focusing on language and learning in mathematics. The study will design and evaluate a school-based intervention that positions language through talk as a key resource in teaching mathematics in Grades 1 and 2. Outcomes of the study will be empirical evidence of the effect of a language-based pedagogy on young students' achievement in mathematics and further understanding of the relationship between talk and learning. These outcomes will inform policy and teacher education and have a long lasting impact on low SES students' educational and work opportunities with ultimate impact on economic and cultural prosperity.
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Shifting the Culture of Out-of-field Professional Education for Teachers. This project aims to model an education system that would diversify the expertise of teachers as part of attending to long-term teacher shortage. It responds to a pressing national need for a system of valued and accessible professional education (PE) for out-of-field teachers. The project draws on perspectives from schools, governments and PE providers to expose current practices, cultural norms, and policies; propose an ....Shifting the Culture of Out-of-field Professional Education for Teachers. This project aims to model an education system that would diversify the expertise of teachers as part of attending to long-term teacher shortage. It responds to a pressing national need for a system of valued and accessible professional education (PE) for out-of-field teachers. The project draws on perspectives from schools, governments and PE providers to expose current practices, cultural norms, and policies; propose an 'ideal' PE ecosystem that values re-specialisation in the core subjects; and develop principles to inform policy and practice needed to attain this ideal. The evidence-based framing of PE will inform efforts by schools, PE providers and policy makers to sustain a highly capable, adaptive and specialised teaching workforce.Read moreRead less
Youth Gangs: The Australian Experience. Little systematic research has been undertaken in Australia into the nature and activities of youth gangs. The aim of this project is to provide a national study of youth group formations, processes of group transformation (toward or away from gangs), and strategies the might be employed to curtail gang formation and gang-related behaviour. The study will involve interviews with young people in each capital city, and focus group discussions with youth serv ....Youth Gangs: The Australian Experience. Little systematic research has been undertaken in Australia into the nature and activities of youth gangs. The aim of this project is to provide a national study of youth group formations, processes of group transformation (toward or away from gangs), and strategies the might be employed to curtail gang formation and gang-related behaviour. The study will involve interviews with young people in each capital city, and focus group discussions with youth service providers in each city. The research methods draw upon the instruments presently being developed by the Eurogang Research Network in order to facilitate cross-national comparisons. It will be the first national study of its kind, and will provide new conceptual insights into the character of youth group formation in Australia, baseline youth gang data, and analysis of possible intervention strategies.
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Powerful knowledge: mapping out standards of teachers' knowledge for teaching mathematics and English to achieve the goals of the curriculum. Setting standards is an important step to raising teacher quality. This project will establish benchmarks for teachers' knowledge at all levels of schooling in two key areas of the curriculum: English and mathematics.
Integrated genetic regulation of photomorphogenesis in Pisum. This project will use a molecular genetic approach in garden pea to investigate the roles of photoreceptors that mediate developmental responses to light. It will define gene families encoding phytochrome, cryptochrome and phototropin photoreceptors, characterise photoreceptor gene expression, and identify mutants with impaired response to light. The mutants will be used in molecular, physiological and biochemical studies to examine h ....Integrated genetic regulation of photomorphogenesis in Pisum. This project will use a molecular genetic approach in garden pea to investigate the roles of photoreceptors that mediate developmental responses to light. It will define gene families encoding phytochrome, cryptochrome and phototropin photoreceptors, characterise photoreceptor gene expression, and identify mutants with impaired response to light. The mutants will be used in molecular, physiological and biochemical studies to examine how photoreceptors control and co-ordinate development throughout the plant via effects on plant hormone synthesis and response. Results from the project will be of practical importance in manipulating key aspects of plant growth to better suit particular environmental and agronomic objectives.Read moreRead less
Molecular pathways controlling light-regulated development in legumes. Legumes are widely grown as forage and grain crops and make a substantial contribution to the Australian economy. Light is an important determinant of plant architecture and productivity and we need to know more about how development is regulated by light in this important plant group. The natural light environment faced by plants is complex and varies with crop density, season and time of day. Understanding the interaction o ....Molecular pathways controlling light-regulated development in legumes. Legumes are widely grown as forage and grain crops and make a substantial contribution to the Australian economy. Light is an important determinant of plant architecture and productivity and we need to know more about how development is regulated by light in this important plant group. The natural light environment faced by plants is complex and varies with crop density, season and time of day. Understanding the interaction of photoreceptors and plant hormones in the control of growth is vital for manipulating crops to meet changing agronomic requirements. Training of students in state-of-the art techniques and the generation of new germplasm for use by other researchers and plant breeders will be other significant outcomes of the project.Read moreRead less
Statistical literacy in the primary school: beginning inference. Australia is committed to building a stronger foundation for school mathematics and science. This project will introduce primary school students to beginning inference, a core component of statistical literacy and an increasingly important life skill. Foundations for secondary mathematics study and productive societal participation will be laid.