Electrical properties of human dendrites. This project aims to determine the electrical properties of dendrites in human neurons. Dendrites are the primary site of synaptic input to neurons and their electrical properties play a key role in information processing in the brain. While we know much about the electrical properties of dendrites in other species, primarily rodents, little is known about the electrical properties of human dendrites. This project aims to address this gap in knowledge fo ....Electrical properties of human dendrites. This project aims to determine the electrical properties of dendrites in human neurons. Dendrites are the primary site of synaptic input to neurons and their electrical properties play a key role in information processing in the brain. While we know much about the electrical properties of dendrites in other species, primarily rodents, little is known about the electrical properties of human dendrites. This project aims to address this gap in knowledge for the first time. The results obtained will shed light on the mechanisms the brain uses to process information, and therefore will bring us a step closer to truly understanding ourselves.Read moreRead less
Novel cell wall genes ripe for the picking. This project aims to investigate the role of recently discovered plant cellulose synthase-like CslM genes and to define the polysaccharide product associated with them. Successful identification of the polysaccharide is highly likely to increase our fundamental understanding of how cell walls are made, how cells stick together or fall apart as well as facilitating the training of the next generation of cell wall biologists in challenging molecular and ....Novel cell wall genes ripe for the picking. This project aims to investigate the role of recently discovered plant cellulose synthase-like CslM genes and to define the polysaccharide product associated with them. Successful identification of the polysaccharide is highly likely to increase our fundamental understanding of how cell walls are made, how cells stick together or fall apart as well as facilitating the training of the next generation of cell wall biologists in challenging molecular and biochemical techniques. This new knowledge could increase our understanding of fruit ripening, and how it might be manipulated. This could have significant downstream commercial benefits if applied to breeding programs of economically important fruit such as grapes, tomatoes and strawberries.Read moreRead less
Role of the superior colliculus in sensory processing. The ability of an organism to attend to, and orient towards, stimuli in the environment is critical for survival. In the mammalian brain, the principal brain region performing this function is the superior colliculus. Despite its importance, little is known about the role the superior colliculus plays in sensory perception. This project addresses this issue by leveraging revolutionary new recording techniques to determine how the superior co ....Role of the superior colliculus in sensory processing. The ability of an organism to attend to, and orient towards, stimuli in the environment is critical for survival. In the mammalian brain, the principal brain region performing this function is the superior colliculus. Despite its importance, little is known about the role the superior colliculus plays in sensory perception. This project addresses this issue by leveraging revolutionary new recording techniques to determine how the superior colliculus codes sensory information and ultimately drives behaviour. The outcomes will be of immediate benefit to scientists studying sensory processing and perceptual decision making, and will help keep Australia at the forefront of brain-inspired engineering and the neuroscience-based knowledge economy.Read moreRead less
Coding of olfactory information in the piriform cortex. This project aims to understand how electrical activity in the primary olfactory (piriform) cortex enables mice to recognise and remember odours. By using optical recording techniques together with genetic tools, the project expects to generate new knowledge about how the mammalian brain builds internal representations of the external world. Specific outcomes of the project include new insights into the functional architecture of the pirifo ....Coding of olfactory information in the piriform cortex. This project aims to understand how electrical activity in the primary olfactory (piriform) cortex enables mice to recognise and remember odours. By using optical recording techniques together with genetic tools, the project expects to generate new knowledge about how the mammalian brain builds internal representations of the external world. Specific outcomes of the project include new insights into the functional architecture of the piriform cortex and fresh understanding of how olfactory information is encoded and stored in neural circuits. More broadly, the project aims to advance our understanding of how the brain works, with benefits for future improvements in artificial intelligence and brain-machine interfaces.Read moreRead less
RNA-binding proteins rewire transcriptomes in immune cell differentiation. This project aims to combine advanced computational and experimental techniques to investigate a new layer of gene regulation by novel RNA binding proteins (RBP) which control messenger RNA length in immune cells. This project expects to demonstrate that these RBPs have a profound effect on immune cell differentiation and response to infection. Expected outcomes include the discovery of new RBPs regulating immunity, with ....RNA-binding proteins rewire transcriptomes in immune cell differentiation. This project aims to combine advanced computational and experimental techniques to investigate a new layer of gene regulation by novel RNA binding proteins (RBP) which control messenger RNA length in immune cells. This project expects to demonstrate that these RBPs have a profound effect on immune cell differentiation and response to infection. Expected outcomes include the discovery of new RBPs regulating immunity, with mechanism and function determined by novel CRISPR editing of a transgenic mouse model. The significant benefit will be a more complete understanding of RNA mechanisms of immune response, which will be critical in informing future advances in the rapidly developing areas of RNA-based biotechnologies and synthetic immunology.Read moreRead less
Building on rural knowledges to unlock the potential of rural students. This project aims to advance understanding of the distinctive knowledges that rural students bring to school and develop teaching practices that build on these rural knowledges to unlock the potential of this significant student population. The project involves collaborating with rural primary schools, teachers, students and communities to identify rural knowledges, study classroom practices in detail, and develop sustainabl ....Building on rural knowledges to unlock the potential of rural students. This project aims to advance understanding of the distinctive knowledges that rural students bring to school and develop teaching practices that build on these rural knowledges to unlock the potential of this significant student population. The project involves collaborating with rural primary schools, teachers, students and communities to identify rural knowledges, study classroom practices in detail, and develop sustainable teaching practices that help students connect rural knowledges and school knowledge. Expected outcomes include a framework of place-based teaching practices and resources that will benefit rural schooling, teacher education, and the education of communities crucial to the nation’s future wealth and welfare.Read moreRead less
Social, economic and health vulnerabilities in Indonesia. This project aims to study and provide ways to overcome vulnerability in Indonesia. Half the Indonesian population is still clustered around the poverty line, contributing to their vulnerability. This project will identify vulnerable groups and why they are vulnerable. Using a common framework of the life course in eight Indonesian field sites, this project will investigate whether social networks and welfare programs reduce vulnerability ....Social, economic and health vulnerabilities in Indonesia. This project aims to study and provide ways to overcome vulnerability in Indonesia. Half the Indonesian population is still clustered around the poverty line, contributing to their vulnerability. This project will identify vulnerable groups and why they are vulnerable. Using a common framework of the life course in eight Indonesian field sites, this project will investigate whether social networks and welfare programs reduce vulnerability, and pinpoint strategies for reducing vulnerabilities in the future. The project expects to show how vulnerable citizens in Indonesia can be made more secure, helping to build a more stable and prosperous region.Read moreRead less
Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovativ ....Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovative and broadly-applicable neuroscience methods and an understanding of receptors involved in plant growth and defense. Benefits of this project include an enhanced capacity to generate knowledge, multidisciplinary training opportunities and patentable synthetic biology technologies.Read moreRead less
Life, living and livelihoods in satellite cities: new urban forms in India . This project aims to assess the success of satellite cities, conceived as possible solutions to the urgent challenge of rapid urban growth in today’s megacities. Through an ethnography of an Indian satellite city, Mahindra World City, this project aims to generate knowledge on new urban formations and the consequences of experiments in urban development for different socio-economic groups. Understanding the lived experi ....Life, living and livelihoods in satellite cities: new urban forms in India . This project aims to assess the success of satellite cities, conceived as possible solutions to the urgent challenge of rapid urban growth in today’s megacities. Through an ethnography of an Indian satellite city, Mahindra World City, this project aims to generate knowledge on new urban formations and the consequences of experiments in urban development for different socio-economic groups. Understanding the lived experiences of residents/workers in satellite cities aims to form a robust evidence base for research driven dialogue with policy makers, planners and developers. Lessons derived are expected to inform policy and practice as to how to achieve wellbeing for urban residents, while providing indications of Asia’s urban futures.Read moreRead less
The Cartography of Peace: Security Zones, Colour Codes and Everyday Life. This project investigates the impacts of security mapping and the use of specific color-codes by United Nations peacekeeping operations when assessing risks. It will for the first time trace the origins of United Nations security mapping practices and compare key case studies: Afghanistan (green zone), Somalia (white zone), South Sudan and Kenya (blue zones) and Haiti (red and yellow zones). Expected outcomes include bette ....The Cartography of Peace: Security Zones, Colour Codes and Everyday Life. This project investigates the impacts of security mapping and the use of specific color-codes by United Nations peacekeeping operations when assessing risks. It will for the first time trace the origins of United Nations security mapping practices and compare key case studies: Afghanistan (green zone), Somalia (white zone), South Sudan and Kenya (blue zones) and Haiti (red and yellow zones). Expected outcomes include better understanding of how policy-makers assess risks on the ground, how security maps are drafted and modified across time, as well as an understanding of the meanings given to specific color-codes. The findings expect to benefit Australian and other policy makers seeking to design better security interventions.Read moreRead less