Characterising The Mechanisms That Control Blood Cell Development
Funder
National Health and Medical Research Council
Funding Amount
$335,616.00
Summary
Hematopoiesis is a tightly regulated process that provides the body with a constant supply of all the cells of the blood system. My studies aim to characterize the molecular mechanisms that regulate the expansion and differentiation of hematopoietic stem cells (HSCs) into each cell lineage. These studies will be key to the effective use of cellular transplantation therapeutic strategies and aim to provide a greater understanding of the mechanisms that underpin proliferative disorders such as can ....Hematopoiesis is a tightly regulated process that provides the body with a constant supply of all the cells of the blood system. My studies aim to characterize the molecular mechanisms that regulate the expansion and differentiation of hematopoietic stem cells (HSCs) into each cell lineage. These studies will be key to the effective use of cellular transplantation therapeutic strategies and aim to provide a greater understanding of the mechanisms that underpin proliferative disorders such as cancer.Read moreRead less
Matching Supply And Demand: How Does Metabolism Fine-tune Signal Transduction?
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
Insulin controls nutrient traffic and disrupting its actions are linked to many diseases: type 2 diabetes, cancer, heart disease. Here, I will test a novel hypothesis that our cells’ metabolic rate, defined by the balance between nutrient supply and energy expenditure, controls how cells respond to insulin. These metabolic regulatory nodes would play a major determinant of many essential functions linked to human health, and thus provide novel therapeutic targets for numerous diseases.
Investigating The Delivery Of Cytotoxic T Cell Lytic Granules And The Microenvironment Of The Immunological Synapse
Funder
National Health and Medical Research Council
Funding Amount
$355,169.00
Summary
T cells recognise infected or cancer cells and eliminate them from the body. They kill their targets by tightly attaching and releasing toxic proteins, which cause the target to undergo cell suicide. This research will use high resolution imaging to investigate the environment of the synapse between the two cells and understand parameters required for the delivery of a lethal hit. This will provide powerful insights into the working of the cell, and may identify novel intervention targets
The Polycomb Ezh2 Methyltransferase Regulates Satellite Cell Self-renewal
Funder
National Health and Medical Research Council
Funding Amount
$333,769.00
Summary
Skeletal muscle regeneration following injury is a tightly regulated process and any disturbance to this process, such as that which occurs with the muscular dystrophies, can greatly impair a muscle's ability to regenerate. The aim of this project is to better understand the mechanisms that control muscle regeneration, and open up new avenues for potential treatment strategies in conditions where muscle wasting and weakness are indicated.