The development of tuneable materials to allow the three-dimensional printing of cells. New low cost three-dimensional (3D) printers and reagents will be developed during this project to allow cancer biologists to print cells and polymers as more realistic 3D tissue models for biological assays. Such technology will be important for performing basic research into cancers as well as for providing better tools for drug testing.
Assessing the impact of habitat restoration on the rates of recovery of four native fish species using advanced statistical models. This project will develop statistical modelling tools to assess how quickly threatened native fish populations recover following habitat restoration. The outcome of this project will aid in understanding the use of habitat restoration in managing endangered stocks of Murray Cod, Trout Cod, Silver Perch and Golden Perch in the Murray River.
Targeted process development for drug delivery. Matrix assisted ball milling and continuous flow process intensification on rotating surfaces in the form of spinning discs and rotating tubes, and combinations of these, allow the fabrication of nanoparticles for the pharmaceutical industry, with the ability to fine tune the properties of the particles to improve their uptake profiles, while minimising side effects. The research will be conducted through the Centre for Strategic Nano-Fabrication w ....Targeted process development for drug delivery. Matrix assisted ball milling and continuous flow process intensification on rotating surfaces in the form of spinning discs and rotating tubes, and combinations of these, allow the fabrication of nanoparticles for the pharmaceutical industry, with the ability to fine tune the properties of the particles to improve their uptake profiles, while minimising side effects. The research will be conducted through the Centre for Strategic Nano-Fabrication with its science based attention to quality by design for product development at the inception of the science. This, coupled with the involvement of iCeutica which has a strong commercially focused R and D profile, provides a more innovative research culture, and excellent research training. Read moreRead less
Enhanced pigment weathering resistance by coating with high dielectric ceramic. The partner company, Tiwest, based in Western Australia, is a major contributor to the economy, and earns more than $A400m annually in exports. It is the only company in the world that mines, separates, refines and manufactures titania products, including pigments, in one region. The current post-titania particle formation wet-coating process, however, presents a major capital and recurrent cost and necessitates a pi ....Enhanced pigment weathering resistance by coating with high dielectric ceramic. The partner company, Tiwest, based in Western Australia, is a major contributor to the economy, and earns more than $A400m annually in exports. It is the only company in the world that mines, separates, refines and manufactures titania products, including pigments, in one region. The current post-titania particle formation wet-coating process, however, presents a major capital and recurrent cost and necessitates a pigment regrind stage. The research will investigate the development of a highly durable dry-coated pigment utilising a novel high dielectric coating. This development has the potential to ensure the partner company's future competitiveness through reduced processing costs and improved product performance.Read moreRead less
Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaire ....Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaired but must be developed to identify the causes of decline. The intended outcomes are improved sustainable water resource management within and among states, and improved natural resource policy development.Read moreRead less
Novel Self Assembled Particle Systems as a Key to Next Generation Biosensor Technology. Development and commercialisation of products utilising nanotechnology is crucial to future wealth creation for Australia. The translational research in this proposal will progress innovative concepts in nanotechnology-based biosensors, with potential for substantial improvements in disease diagnosis, leading to more economical and timely therapy. The products that arise from this research will also provide f ....Novel Self Assembled Particle Systems as a Key to Next Generation Biosensor Technology. Development and commercialisation of products utilising nanotechnology is crucial to future wealth creation for Australia. The translational research in this proposal will progress innovative concepts in nanotechnology-based biosensors, with potential for substantial improvements in disease diagnosis, leading to more economical and timely therapy. The products that arise from this research will also provide further employment for Australians, building on Universal Biosensor’s proven record of commercialization in Australia. The project will lead to training of Australian researchers in nanotechnology and in utilization of key Australian science infrastructure including the Australian Synchrotron and the Melbourne Centre for Nanofabrication.Read moreRead less
Optimisation of Coal Flotation Performance. The aim of this project is to improve the cleaning of coal by flotation across the whole particle size range with maximum rejection of mineral matter and decreased reagent consumption. The factors that influence coal flotation will be identified and used to predict coal flotation performance. In particular the ultimate separability of coal will be addressed through a unique combination of in- and ex- situ pulp chemical and physical measurements, embedd ....Optimisation of Coal Flotation Performance. The aim of this project is to improve the cleaning of coal by flotation across the whole particle size range with maximum rejection of mineral matter and decreased reagent consumption. The factors that influence coal flotation will be identified and used to predict coal flotation performance. In particular the ultimate separability of coal will be addressed through a unique combination of in- and ex- situ pulp chemical and physical measurements, embedded in a comprehensive model of coal flotation.Read moreRead less
Optimisation of pigment coating surface treatments. Control and optimisation of surface coatings in pigment processing will lead to improved production efficiency and quality. In pigment processing, technology developed in this project may not only save millions of dollars in increased production efficiency but also lead to improved pigment optical performance in pigment applications such as paints, plastics and pharmaceuticals.
Improved biomonitoring of urban freshwater ecosystems using DNA barcodes. This project aims to provide rapid diagnostic detection of environmental change in aquatic ecosystems at reduced cost. Next-generation sequencing (NGS) can transform monitoring of aquatic ecosystems by identifying many species in multiple biological samples. This project aims to use NGS technology to identify macroinvertebrate species as biological indicators in urban freshwater ecosystems to provide more rapid, sensitive ....Improved biomonitoring of urban freshwater ecosystems using DNA barcodes. This project aims to provide rapid diagnostic detection of environmental change in aquatic ecosystems at reduced cost. Next-generation sequencing (NGS) can transform monitoring of aquatic ecosystems by identifying many species in multiple biological samples. This project aims to use NGS technology to identify macroinvertebrate species as biological indicators in urban freshwater ecosystems to provide more rapid, sensitive and cost-effective monitoring compared to traditional methods. The project uses DNA barcodes that identify species to detect species in samples processed with NGS. The project also plans to use previously collected samples to explore species diversity and detect indicator species.Read moreRead less
Investigating movement, distribution, abundance and diet to support management objectives for threatened riverine predators in Northern Australia. The rivers and estuaries of northern Australia are highly productive environments, containing an exceptional diversity and abundance of large predatory aquatic species. This project aims to monitor the movements, habitat preferences and diet in eight large predatory species in a northern Queensland river over the next three years. Movement data will b ....Investigating movement, distribution, abundance and diet to support management objectives for threatened riverine predators in Northern Australia. The rivers and estuaries of northern Australia are highly productive environments, containing an exceptional diversity and abundance of large predatory aquatic species. This project aims to monitor the movements, habitat preferences and diet in eight large predatory species in a northern Queensland river over the next three years. Movement data will be combined with isotopic analysis to reveal how environmental and biological factors drive animal movements and impact habitat connectivity. In a world of vanishing top predators, it is imperative to understand system dynamics before we can evaluate the impact of species removal on ecosystem function.Read moreRead less