Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100075
Funder
Australian Research Council
Funding Amount
$315,000.00
Summary
Acoustic liquid handling robotics for bioactive compound discovery. This project aims to use a Labcyte Echo 550 acoustic dispenser with Combination Software to deliver sophisticated assay-ready screening. The Echo is the only liquid handling dispenser for 1536-well microplates and will allow Australian researchers to develop assay miniaturisation. The robotics will provide our nation’s researchers with a distinct competitive edge by enhancing assay sophistication, accuracy and reproducibility wh ....Acoustic liquid handling robotics for bioactive compound discovery. This project aims to use a Labcyte Echo 550 acoustic dispenser with Combination Software to deliver sophisticated assay-ready screening. The Echo is the only liquid handling dispenser for 1536-well microplates and will allow Australian researchers to develop assay miniaturisation. The robotics will provide our nation’s researchers with a distinct competitive edge by enhancing assay sophistication, accuracy and reproducibility while reducing cost. The expected benefits will advance the elucidation of molecular mechanisms involved in complex biological phenomena. The benefits of this are substantial, including reduction in test compound and reagents, which in turn reduces laboratory costs, conserves cells and increases data quality.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100040
Funder
Australian Research Council
Funding Amount
$4,997,903.00
Summary
ARC Training Centre for Facilitated Advancement of Australia's Bioactives (FAAB). The Centre for Facilitated Advancement of Australia's Bioactives (FAAB) will transform the rapidly growing bioactive ingredients sector. It will apply advanced analytical methods to molecular characterisation of bioactive products derived from foods, food-waste, and cell-based biotechnologies. FAAB will determine modes of action for bioactives with potential lifestyle and nutritional benefits allowing for evidence- ....ARC Training Centre for Facilitated Advancement of Australia's Bioactives (FAAB). The Centre for Facilitated Advancement of Australia's Bioactives (FAAB) will transform the rapidly growing bioactive ingredients sector. It will apply advanced analytical methods to molecular characterisation of bioactive products derived from foods, food-waste, and cell-based biotechnologies. FAAB will determine modes of action for bioactives with potential lifestyle and nutritional benefits allowing for evidence-informed decision-making, and regulatory framework development. FAAB graduates will lead and deliver future national self-reliance to the Australian bioactives sector, increasing diversification and international competitiveness and development of regulation in a growing market. Read moreRead less
Trojan Y as a genetic solution for controlling and eradicating the Eastern mosquitofish, Gambusia holbrooki. The project aims to develop applied genetic strategies to eradicate Gambusia, a serious invasive pest fish species, from a Tasmanian estuary. The goal is to advance the Trojan Y chromosome model from theory to an applied solution. The project aims to employ an integrated ecological, physiological, behavioural, genetic and genomics approach, within the unique island-within-an-island status ....Trojan Y as a genetic solution for controlling and eradicating the Eastern mosquitofish, Gambusia holbrooki. The project aims to develop applied genetic strategies to eradicate Gambusia, a serious invasive pest fish species, from a Tasmanian estuary. The goal is to advance the Trojan Y chromosome model from theory to an applied solution. The project aims to employ an integrated ecological, physiological, behavioural, genetic and genomics approach, within the unique island-within-an-island status of Gambusia infestation in Tasmania.Read moreRead less
Functional characterisation of contaminant-nanoparticle associations. Nanoparticles present in the environment modify the movement and toxicity of contaminants. This project targets key gaps that hinder the ability to predict the fate and behaviour of environmental contaminants; this will lead to the optimisation of legislative framework and the management/remediation of contaminated sites (for example, mine sites, landfills).
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100141
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
High sensitivity and precision mass spectrometry for tracing Australia's ancient evolution and securing our future groundwater resources. High sensitivity and precision mass spectrometry for tracing Australia’s ancient evolution and securing our future groundwater resources: Micro-sampling thermal ionisation mass spectrometry (TIMS) provides the ability to undertake ultra low-level isotope analysis of earth and environmental samples. Analysis of radiogenic (for example, Neodymium, Strontium and ....High sensitivity and precision mass spectrometry for tracing Australia's ancient evolution and securing our future groundwater resources. High sensitivity and precision mass spectrometry for tracing Australia’s ancient evolution and securing our future groundwater resources: Micro-sampling thermal ionisation mass spectrometry (TIMS) provides the ability to undertake ultra low-level isotope analysis of earth and environmental samples. Analysis of radiogenic (for example, Neodymium, Strontium and Lead) and stable (for example, Boron) isotopes allows researchers to trace the evolution of the Australian continent from its beginnings in the Precambrian through to the impacts of climate change in the Quaternary period (the last 2.6 million years). The proposed micro-sampling TIMS facility will give researchers the opportunity to characterise mineral deposit formation, paleoclimate records and groundwater sources with new levels of accuracy and precision. This will help secure the economic and environmental future of Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100183
Funder
Australian Research Council
Funding Amount
$715,000.00
Summary
An ICP-ToF-MS facility for environmental, mineral and biological science. This project aims at establishing a facility for the detection, quantification and rapid mapping of elements and their isotopes in nanoparticles and a diverse set of biological and earth materials. The facility consists of a latest generation ICP-ToF-MS that can simultaneously collect a full suite of isotopic information (Li to U) from liquid samples or, in combination with laser ablation and laser induced breakdown spectr ....An ICP-ToF-MS facility for environmental, mineral and biological science. This project aims at establishing a facility for the detection, quantification and rapid mapping of elements and their isotopes in nanoparticles and a diverse set of biological and earth materials. The facility consists of a latest generation ICP-ToF-MS that can simultaneously collect a full suite of isotopic information (Li to U) from liquid samples or, in combination with laser ablation and laser induced breakdown spectroscopy, solid samples. It will enhance capabilities and sample throughput in environmental science, geoscience, biology and cultural heritage research, significantly accelerating the discovery of new ore bodies, improving environmental risk assessment and assisting research in cancer biology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100183
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Protein Quantitation Centre of South Australia renewal for Systems Biology. This application aims to renew Mass Spectrometry (MS) instrumentation to characterise and quantify Biomolecules towards a better understanding of biological processes. UniSA, Uni Adelaide, Flinders have established the Protein Quantitation Centre of South Australia (PQCSA) in 2013 through an ARC LIEF lead by CI Hoffmann and this application will renew and expand MS capacity towards metabolites, glycans and lipids. This ....Protein Quantitation Centre of South Australia renewal for Systems Biology. This application aims to renew Mass Spectrometry (MS) instrumentation to characterise and quantify Biomolecules towards a better understanding of biological processes. UniSA, Uni Adelaide, Flinders have established the Protein Quantitation Centre of South Australia (PQCSA) in 2013 through an ARC LIEF lead by CI Hoffmann and this application will renew and expand MS capacity towards metabolites, glycans and lipids. This will enable researchers in South Australia to work towards a full understanding of biological processes and towards expanding their knowledge to Systems Biology. Expected outcome of the projects are multiple interdisciplinary collaborations between the CI's and should provide significant benefits in research outputs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100155
Funder
Australian Research Council
Funding Amount
$909,079.00
Summary
Advancing 4D fluorescence microscopy within Australia. This multi-institutional proposal aims to establish a state-of-the-art Lightsheet microscope facility in South Australia with enhanced analysis infrastructure and a national user support network. Expectations are, this will transform researcher outcomes for multiple disciplines by facilitating high-resolution four-dimensional interrogation of novel biological processes. Significant benefits will include the ability to image deep within livin ....Advancing 4D fluorescence microscopy within Australia. This multi-institutional proposal aims to establish a state-of-the-art Lightsheet microscope facility in South Australia with enhanced analysis infrastructure and a national user support network. Expectations are, this will transform researcher outcomes for multiple disciplines by facilitating high-resolution four-dimensional interrogation of novel biological processes. Significant benefits will include the ability to image deep within living tissue over long time-scales without inducing phytotoxicity to produce high-impact fundamental and translatable outcomes, the development of novel probes and methodologies, new cross-disciplinary collaborations, and new and unique funding, student training and public engagement opportunities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100174
Funder
Australian Research Council
Funding Amount
$380,000.00
Summary
Development of a digital Transmission Electron Microscope Facility in Tasmania. Development of a digital transmission electron microscope facility: Transmission electron microscopy is a fundamental tool for the study of biological systems at the ultrastructural level. This project will establish a facility that will be accessible to a range of biological researchers, replacing aged and non-sustainable electron microscopy facilities. The instrument will revitalise cellular research and provide ad ....Development of a digital Transmission Electron Microscope Facility in Tasmania. Development of a digital transmission electron microscope facility: Transmission electron microscopy is a fundamental tool for the study of biological systems at the ultrastructural level. This project will establish a facility that will be accessible to a range of biological researchers, replacing aged and non-sustainable electron microscopy facilities. The instrument will revitalise cellular research and provide additional insights and outcomes related to the study of intracellular features in a diverse range of systems and models. This will add substantially to the knowledge base across a wide range of fields of research, increasing national contributions in the areas of neuroscience, separation science and marine science.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100141
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
High-resolution ITRAX XRF core scanning facility for global change research. This facility will enable researchers to obtain high-resolution geochemical profiles in the study of environmental change and climate variability. It will provide archive data on the variation of density and chemical element composition along sediment and soil cores, rock cores, wood samples, speleothems and corals. These archives contain important information such as human activity, climate variability, water quality c ....High-resolution ITRAX XRF core scanning facility for global change research. This facility will enable researchers to obtain high-resolution geochemical profiles in the study of environmental change and climate variability. It will provide archive data on the variation of density and chemical element composition along sediment and soil cores, rock cores, wood samples, speleothems and corals. These archives contain important information such as human activity, climate variability, water quality changes, pollution histories, recent geomorphological change, land-use change, introduction of invasive species and the occurrence of bushfires. A better understanding of the occurrence and timing of these major environmental issues is of national and regional importance.Read moreRead less