Innovations in peptide-based drug design. This project will aim to develop new types of drugs that fill a gap between existing small molecule drugs, which are relatively inexpensive and stable, but often have side-effects, and biologics which are very expensive and require injection. Our new generation of peptide-based drugs promise to be applicable to diseases that are not treatable by current drugs.
Fragment based screening to deliver drugs targeting tuberculosis and the gametocyte and liver stages of Plasmodium. This project will identify natural products that bind to critical proteins in malaria and tuberculosis to discover new ways to treat these diseases.
Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaire ....Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaired but must be developed to identify the causes of decline. The intended outcomes are improved sustainable water resource management within and among states, and improved natural resource policy development.Read moreRead less
Oxytocin receptor PET ligands: imaging the love receptor’s engagement. This project aims to develop a positron emission tomography (PET) ligand for the oxytocin receptor. This novel platform is significant as it will allow the scientific community to answer questions about the role of the oxytocin receptor in the important process of social behaviour which underlies quality of life. This knowledge gap has remained unanswered for decades due to the lack of specific techniques to measure oxytocin ....Oxytocin receptor PET ligands: imaging the love receptor’s engagement. This project aims to develop a positron emission tomography (PET) ligand for the oxytocin receptor. This novel platform is significant as it will allow the scientific community to answer questions about the role of the oxytocin receptor in the important process of social behaviour which underlies quality of life. This knowledge gap has remained unanswered for decades due to the lack of specific techniques to measure oxytocin receptor engagement. It is also significant as it will equip Australian startup Kinoxis Therapeutics to progress their molecules to market, a process enabled by measuring oxytocin receptor engagement. Our dual expertise on the oxytocin receptor and PET ligand development uniquely situate us to generate this technology.Read moreRead less
Hydrogeological drivers and fate of spring flow in a semi-arid setting. In arid and semi-arid climates, aquatic and terrestrial ecosystems often rely on groundwater springs. Spring hydrology depends on complex relationships between underlying aquifers and surface conditions, leading to high uncertainties in understanding aquifer-spring-wetland hydrology, which is critical for spring ecosystem protection and to inform management of relevant groundwater-affecting activities. This project will appl ....Hydrogeological drivers and fate of spring flow in a semi-arid setting. In arid and semi-arid climates, aquatic and terrestrial ecosystems often rely on groundwater springs. Spring hydrology depends on complex relationships between underlying aquifers and surface conditions, leading to high uncertainties in understanding aquifer-spring-wetland hydrology, which is critical for spring ecosystem protection and to inform management of relevant groundwater-affecting activities. This project will apply novel hydrogeophysical and hydrochemical methods, and computer modelling, to investigate the source aquifer of, and fate of discharge from the Doongmabulla Springs Complex (DSC), located in an area of future development. Project results will inform spring vulnerability to development pressures and climate effects.Read moreRead less
Investigating movement, distribution, abundance and diet to support management objectives for threatened riverine predators in Northern Australia. The rivers and estuaries of northern Australia are highly productive environments, containing an exceptional diversity and abundance of large predatory aquatic species. This project aims to monitor the movements, habitat preferences and diet in eight large predatory species in a northern Queensland river over the next three years. Movement data will b ....Investigating movement, distribution, abundance and diet to support management objectives for threatened riverine predators in Northern Australia. The rivers and estuaries of northern Australia are highly productive environments, containing an exceptional diversity and abundance of large predatory aquatic species. This project aims to monitor the movements, habitat preferences and diet in eight large predatory species in a northern Queensland river over the next three years. Movement data will be combined with isotopic analysis to reveal how environmental and biological factors drive animal movements and impact habitat connectivity. In a world of vanishing top predators, it is imperative to understand system dynamics before we can evaluate the impact of species removal on ecosystem function.Read moreRead less
Growing a sustainable new molecular resource. This project will provide access to a unique and unexplored Australian molecular resource pre-programmed by evolution for therapeutic potential. These discoveries will enable important biomedical research and advance the development of new improved drugs that treat a diverse array of human diseases and illness.
Can we see the wood for the trees? Effective restoration strategies in rapidly changing subtropical river systems. Addressing the issue of degraded waterways nationally will cost billions of dollars; in southeast Queensland alone it is estimated that it will cost $500 million. Fundamental research is needed to ensure such efforts achieve the desired outcomes. Previous research has shown riverbank erosion is a key stressor for water quality. This project aims to link fluvial disturbance with the ....Can we see the wood for the trees? Effective restoration strategies in rapidly changing subtropical river systems. Addressing the issue of degraded waterways nationally will cost billions of dollars; in southeast Queensland alone it is estimated that it will cost $500 million. Fundamental research is needed to ensure such efforts achieve the desired outcomes. Previous research has shown riverbank erosion is a key stressor for water quality. This project aims to link fluvial disturbance with the capacity for effective riparian restoration in subtropical river systems at a local, reach and whole of catchment scale. The outcome aims to develop decision-support tools and methods for industry partners to invest in catchment-scale restoration activities in order to manage the risks to drinking water quality and aquatic ecosystem health from riverbank erosion.Read moreRead less
Restoring functional links between riparian zones and streams by enhancing structural retention. This project aims to test whether structural retention, whereby plant detritus (logs, bark, leaves) is trapped and retained within river channels, can offset the impacts caused by widespread clearance of vegetation along river banks, a widespread problem in Australia and the world. Theoretically, retention is a major environmental driver of ecosystem change in rivers, but this has rarely been tested, ....Restoring functional links between riparian zones and streams by enhancing structural retention. This project aims to test whether structural retention, whereby plant detritus (logs, bark, leaves) is trapped and retained within river channels, can offset the impacts caused by widespread clearance of vegetation along river banks, a widespread problem in Australia and the world. Theoretically, retention is a major environmental driver of ecosystem change in rivers, but this has rarely been tested, particularly in a restoration context. The aim of this project is to show that increasing retention results in higher species diversity, thus providing managers with a relatively straightforward method for improving the environmental conditions of rivers, while simultaneously testing three hypotheses about rectifying ecosystem degradation caused by human impacts.Read moreRead less
Advancing hybrid imaging with magnetic resonance imaging and positron emission tomography (MRI-PET). This project aims to increase the utility, accessibility, cost-effectiveness and accuracy of magnetic resonance imaging and positron emission tomography (MRI-PET) hybrid imaging technology for brain tumour imaging. This project will develop new contrast agents, better ways of measuring their uptake including a new high sensitivity MRI-PET head coil and methods for predicting tumour progression us ....Advancing hybrid imaging with magnetic resonance imaging and positron emission tomography (MRI-PET). This project aims to increase the utility, accessibility, cost-effectiveness and accuracy of magnetic resonance imaging and positron emission tomography (MRI-PET) hybrid imaging technology for brain tumour imaging. This project will develop new contrast agents, better ways of measuring their uptake including a new high sensitivity MRI-PET head coil and methods for predicting tumour progression using imaging information.Read moreRead less