Barriers and pathways to development of Indigenous traditional medicines. This project aims to explore how Australian regulatory systems can better support Aboriginal and Torres Strait Islander Traditional Knowledge (TK) holders to commercialise their traditional medicines. Focusing on the mudjala plant and working with the Kimberley’s Nyikina people, the project should generate new anthropological methods for documenting TK related to traditional medicine, new models for regulating traditional ....Barriers and pathways to development of Indigenous traditional medicines. This project aims to explore how Australian regulatory systems can better support Aboriginal and Torres Strait Islander Traditional Knowledge (TK) holders to commercialise their traditional medicines. Focusing on the mudjala plant and working with the Kimberley’s Nyikina people, the project should generate new anthropological methods for documenting TK related to traditional medicine, new models for regulating traditional medicinal products, and pharmacological insights into traditional methods of activating the plant. Additional expected outcomes include unlocking the significant, untapped potential for Indigenous Australians to benefit from the development of traditional medicine products regulated by the Therapeutic Goods Administration.Read moreRead less
A new platform technology for gene therapy . The project aims to make a landmark contribution to biological science by enabling programmed delivery of therapeutic payloads from biocompatible materials. It will employ a novel synthetic biology approach to form two distinct peptide-enabled molecular architectures in a single system. This is expected to deliver a platform technology that will allow successful programmed delivery of viral vectors. The project is likely to deliver significant societa ....A new platform technology for gene therapy . The project aims to make a landmark contribution to biological science by enabling programmed delivery of therapeutic payloads from biocompatible materials. It will employ a novel synthetic biology approach to form two distinct peptide-enabled molecular architectures in a single system. This is expected to deliver a platform technology that will allow successful programmed delivery of viral vectors. The project is likely to deliver significant societal benefit as a fundamental scientific platform, improving Australia's capacity and impact in the agriculture and the healthcare sectors. The platform technology has the potential to increase the quality of life for patients and their carers, while also produce fitter, healthier livestock.Read moreRead less
Improving water quality modelling by better understanding solute transport. Poor stream water quality is a critical problem in Australia and globally. Stream water quality depends directly on pathways and time taken for water to transport pollutants through catchments. Predicting these pathways is highly challenging and currently requires specialised data. This project aims to better model the movement of water from rainfall to streams, enable greatly improved use of water quality data routinely ....Improving water quality modelling by better understanding solute transport. Poor stream water quality is a critical problem in Australia and globally. Stream water quality depends directly on pathways and time taken for water to transport pollutants through catchments. Predicting these pathways is highly challenging and currently requires specialised data. This project aims to better model the movement of water from rainfall to streams, enable greatly improved use of water quality data routinely collected in Australia's catchments and thereby better predict water quality behaviour. Proposed field studies aim to support this development. The outcomes sought are improved planning and management of water quality in our rivers, lakes and estuaries, improved health of these water bodies and improved water supplies.Read moreRead less
Linking terrestrial–aquatic fluxes to rectify the Australian carbon balance. This project aims to rectify the Australian carbon balance by determining the amount of terrestrial carbon that is lost to streams and rivers across the country. Through a novel integration of high-resolution hydrochemical and gas measurements, remote sensing and machine learning algorithms, the project intends to generate new knowledge about the links between terrestrial carbon sequestration and aquatic carbon export. ....Linking terrestrial–aquatic fluxes to rectify the Australian carbon balance. This project aims to rectify the Australian carbon balance by determining the amount of terrestrial carbon that is lost to streams and rivers across the country. Through a novel integration of high-resolution hydrochemical and gas measurements, remote sensing and machine learning algorithms, the project intends to generate new knowledge about the links between terrestrial carbon sequestration and aquatic carbon export. Expected outcomes include a refined estimate of the net carbon sequestration potential across Australian biomes and seasons. This should provide significant benefits such as avoiding misalignment of greenhouse gas abatement policies and advancing carbon cycling models and predictions.Read moreRead less
Upscaling genetic management of wildlife populations. Earth’s biodiversity is in crisis: many species are threatened with extinction and need our help. Genetic management helps to stop extinctions and promotes the health and continued existence of our wildlife. This project aims to understand how to use genome science to support preservation of four endangered species in changing climates and apply these learnings to help other species to survive and thrive. Anticipated outcomes include innovati ....Upscaling genetic management of wildlife populations. Earth’s biodiversity is in crisis: many species are threatened with extinction and need our help. Genetic management helps to stop extinctions and promotes the health and continued existence of our wildlife. This project aims to understand how to use genome science to support preservation of four endangered species in changing climates and apply these learnings to help other species to survive and thrive. Anticipated outcomes include innovative approaches to aid conservation decision-making, automated analyses of genome data, and improved conservation training. The expected benefits include larger, healthier populations of four species, new ways of saving other species, and the provision of important resources for conservation managers.Read moreRead less
Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outco ....Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outcomes include innovative genetic rescue protocols, a framework for genetic rescue, and leading-edge conservation training. Expected benefits are increased persistence of species that are otherwise unresponsive to management, and a new path to saving endangered species.Read moreRead less
Rivers of Gold: The Legacy of Historical Gold Mining for Victoria's Rivers. By considering rivers as cultural artefacts, this project aims to evaluate how historical gold mining has shaped river systems in Victoria. Victoria’s historic mining industry led to extensive and long-lasting change to waterways across the state. The project plans to integrate approaches from landscape archaeology, physical geography, geomorphology and environmental chemistry to identify and map the extent of changes, i ....Rivers of Gold: The Legacy of Historical Gold Mining for Victoria's Rivers. By considering rivers as cultural artefacts, this project aims to evaluate how historical gold mining has shaped river systems in Victoria. Victoria’s historic mining industry led to extensive and long-lasting change to waterways across the state. The project plans to integrate approaches from landscape archaeology, physical geography, geomorphology and environmental chemistry to identify and map the extent of changes, including increased sedimentation, erosion, and chemical contamination. The project plans to demonstrate how historical mining continues to influence chemical and physical processes in Victorian streams and to develop understanding of the landscapes experienced by Victorians at the height of the mining boom. Project outcomes may provide improved context for catchment and reservoir management and counter prevailing impressions about causes of observed damage to rivers.Read moreRead less
Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This k ....Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment.
Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.
Read moreRead less