Cellular Mechanisms Controlling Neural Crest Cell Migration Along The Developing Gut
Funder
National Health and Medical Research Council
Funding Amount
$368,895.00
Summary
Within the wall of the gut, there are a large number of neurons, probably more than are in the spinal cord. These enteric neurons play an essential role in controlling a number of gut functions including peristalsis (the propulsion of contents along the gut). Most of the neurons in the gut, including those in the large intestine, arise from precursors that emigrate from the hindbrain, and then migrate into and along the gastrointestinal tract during development. The colonization of the gut by ne ....Within the wall of the gut, there are a large number of neurons, probably more than are in the spinal cord. These enteric neurons play an essential role in controlling a number of gut functions including peristalsis (the propulsion of contents along the gut). Most of the neurons in the gut, including those in the large intestine, arise from precursors that emigrate from the hindbrain, and then migrate into and along the gastrointestinal tract during development. The colonization of the gut by neuron precursors takes 5 days in mice and 6 weeks in humans. Studies of the mechanisms controlling the migration of neuron precursors along the gut have provided fundamental information about cell migration in general. Genetic studies in humans and mice have identified some of the genes that are necessary for the migration of neuron precursors along the gastrointestinal tract, but for some of the key genes, their precise role is unknown. We have recently developed a method for imaging living neuron precursors migrating through explants of embryonic mouse gut. In the current proposal we will meld imaging and genetic studies to understand how mutations in particular genes lead to migration defects. In particular, how do particular mutations affect the migratory behaviour of enteric neural precursors? We have also previously shown that neuron precursors migrate along the gut in close association with axons. We will examine the nature of these interactions - in particular, who is following whom, and what happens when cell migration and axon growth are uncoupled? These studies, which will investigate a number of critical aspects of the migration of neural precursors into and along the developing gut, are central to understanding how the enteric nervous system is established along the gastrointestinal tract.Read moreRead less
The Role Of The Zinc Finger Transcriptional Repressor Znf238 During Nerve Cell Maturation
Funder
National Health and Medical Research Council
Funding Amount
$394,264.00
Summary
Proper foetal brain assembly is critical for brain function, but the underlying genetic mechanisms remain poorly defined. In this study, I will investigate a family of proteins that “turn on” neural gene expression in combination with another protein that “turns off” their expression during nerve cell development. Understanding this novel on/off mechanism for controlling gene expression in newborn nerve cells will further our understanding of how the brain is assembled.
Mobility Shocks: Understanding disruptions to Australian migration. This Fellowship aims to generate new knowledge about the impacts of the Covid-19 pandemic on human migration and mobility, in order to advance understanding of major disruptive changes to population movement more broadly. Fellowship outcomes will include designing innovative geospatial research methods, linking and analysing cutting-edge datasets, and building cross-sector collaborations, in order to develop a new theory of ‘Mob ....Mobility Shocks: Understanding disruptions to Australian migration. This Fellowship aims to generate new knowledge about the impacts of the Covid-19 pandemic on human migration and mobility, in order to advance understanding of major disruptive changes to population movement more broadly. Fellowship outcomes will include designing innovative geospatial research methods, linking and analysing cutting-edge datasets, and building cross-sector collaborations, in order to develop a new theory of ‘Mobility Shocks’. This will benefit Australia and its migration partners with new ideas, tools, evidence and expertise to help scholars, policy makers and practitioners to understand, anticipate, and manage future disruptive changes to human migration and mobility in the Australian context and beyond.Read moreRead less
Mechanisms Guiding Pathfinding And Positioning Of Cortical Interneurons
Funder
National Health and Medical Research Council
Funding Amount
$621,606.00
Summary
Brain disorders place an economic and social burden on Australia and the personal costs of these illnesses are immeasurable. Several brain abnormalities are caused from the failure of neurons to position themselves in the correct location when the brain develops. Our study aims to discover how neurons move and what factors influence this process. It provides an understanding of normal brain development, as well as providing insight into what may go wrong in the formation of brain diseases.
Discovery Early Career Researcher Award - Grant ID: DE160101574
Funder
Australian Research Council
Funding Amount
$374,360.00
Summary
Understanding the Long-Term Decline in Internal Migration. The project seeks to provide insights into the changing nature of internal migration. Internal migration rates have declined continuously since the 1970s in most advanced economies. This decline in human mobility may affect the functioning of the economy and individuals’ aspirations, but remains poorly recognised and understood. This project aims to establish the onset and pace of the migration decline for a sample of countries. It also ....Understanding the Long-Term Decline in Internal Migration. The project seeks to provide insights into the changing nature of internal migration. Internal migration rates have declined continuously since the 1970s in most advanced economies. This decline in human mobility may affect the functioning of the economy and individuals’ aspirations, but remains poorly recognised and understood. This project aims to establish the onset and pace of the migration decline for a sample of countries. It also aims to identify the causes of this change by identifying linkages between the drop in migration rates and the broader socio-demographic transitions of the past 30 years in Australia, Canada and the United Kingdom. Understanding this issue may support the development of appropriate economic and social policy responses.Read moreRead less
Transition to adulthood in greater Jakarta: A longitudinal perspective. Interviewing 3,000 young adult Indonesians at two points in time, this project examines whether their economic and social outcomes change across time or whether early experience determines longer-term outcomes. What are the factors involved in transition to adulthood among young people in a rapidly developing metropolis of a developing country?
The Role Of Force-sensing Ion Channels In Melanoma Migration
Funder
National Health and Medical Research Council
Funding Amount
$553,848.00
Summary
Metastasis of melanoma cells away from the primary tumour site carries a very poor patient prognosis.This research aims to characterise a novel signalling pathway that can regulate the migration (movement) of melanoma cells. This signalling pathway depends on force-sensing platforms that can rapidly convert physical inputs from the environment into an electrical signal within the cell. We are working to understand how these force-sensors function.
A Place to Call Home: expediting repatriation and ending the practice of warehousing refugees and internally displaced persons (IDPs). Half of the world's 12 million refugees and 25 million IDPs have been living in camps for five to ten years (and longer). The proposed model for refugee and IDP repatriation and reintegration will: significantly increase their human security; alleviate the economic burden on host countries; contribute to the development goals of the countries of origin; facilitat ....A Place to Call Home: expediting repatriation and ending the practice of warehousing refugees and internally displaced persons (IDPs). Half of the world's 12 million refugees and 25 million IDPs have been living in camps for five to ten years (and longer). The proposed model for refugee and IDP repatriation and reintegration will: significantly increase their human security; alleviate the economic burden on host countries; contribute to the development goals of the countries of origin; facilitate the targeting of humanitarian assistance for resolving protracted refugee and IDP situations; and reduce the threats to regional stability. The research will also enhance both Australia's reputation in this humanitarian sector and its institutional capacity to successfully repatriate and reintegrate refugees and IDPs.Read moreRead less
From Migrant to Worker: New Transnational Responses to Temporary Labour Migration in East and Southeast Asia. This project compares the nature and impact of civil society initiatives concerning temporary labour migration in Hong Kong, Korea, Malaysia, Singapore and Taiwan. It provides a model for understanding NGO-union cooperation on migrant labour issues, useful not only in East and Southeast Asia, where foreign workers - and foreign workers' rights - are already matters of serious concern, bu ....From Migrant to Worker: New Transnational Responses to Temporary Labour Migration in East and Southeast Asia. This project compares the nature and impact of civil society initiatives concerning temporary labour migration in Hong Kong, Korea, Malaysia, Singapore and Taiwan. It provides a model for understanding NGO-union cooperation on migrant labour issues, useful not only in East and Southeast Asia, where foreign workers - and foreign workers' rights - are already matters of serious concern, but in countries like Australia, where skills shortages and ageing populations are increasing pressure on governments to allow large-scale temporary foreign labour. The project's findings will assist government agencies and local and transnational civil society groups to respond more effectively to temporary labour migration.Read moreRead less
The glomerulus is the filtering component of the kidney. In many diseases, it can be the target of an inappropriate inflammatory response. As part of this response, white blood cells accumulate in the glomerulus where they cause damage. In this project, we make use of special microscopes to examine the glomerulus during an inflammatory response, with the aim of understanding the actions of leukocytes present in glomeruli and how they cause inflammation and damage the glomerulus.