Submarine explosive eruptions of silicic magma: constraints on products and processes from modern sea-floor examples, ancient successions and experiments. Volcanoes are common on the sea-floor. Many have been the sites of devastating explosive eruptions throughout Earth history, producing thick layers of pumice and volcanic ash in both modern and ancient ocean basins. None of these events has been witnessed, hence, little is known about submarine explosive eruptions and the associated volcanoes. ....Submarine explosive eruptions of silicic magma: constraints on products and processes from modern sea-floor examples, ancient successions and experiments. Volcanoes are common on the sea-floor. Many have been the sites of devastating explosive eruptions throughout Earth history, producing thick layers of pumice and volcanic ash in both modern and ancient ocean basins. None of these events has been witnessed, hence, little is known about submarine explosive eruptions and the associated volcanoes. This detailed, multidisciplinary study will link exploration of modern explosive sea-floor volcanoes (western Pacific Ocean), field-work on older, submarine volcanic formations (Japan, Greece) and experiments that simulate explosive eruptions and their products. The results will elucidate sea-floor explosive volcanism and its contribution to the geology of ocean basins.Read moreRead less
From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100094
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Development of a world-class facility for three dimensional dynamic testing. Development of a world-class facility for three dimensional dynamic testing: This project aims to establish a world-class facility for multi-directional dynamic testing. Currently there are no such facilities in Australia. The ability to recreate dynamic motion in all available degrees-of-freedom opens up enormous fields of research not currently possible in Australia. This includes such areas as vibration testing, mate ....Development of a world-class facility for three dimensional dynamic testing. Development of a world-class facility for three dimensional dynamic testing: This project aims to establish a world-class facility for multi-directional dynamic testing. Currently there are no such facilities in Australia. The ability to recreate dynamic motion in all available degrees-of-freedom opens up enormous fields of research not currently possible in Australia. This includes such areas as vibration testing, materials testing, biomechanics and human factors, blast and earthquake simulations, field robotics, automotive safety research, flight/vehicle simulation, and marine applications including sloshing of liquids and liquefaction of fines. In conjunction with a 3D laser doppler system this facility will be unique in the world for dynamic mechanical testing.Read moreRead less
The novel production and analysis of breaking waves utilising circular-track moving disturbances. Surfing is a major industry in Australia, contributing $11billion to the economy. It has high active participation levels; but locations with good surfing conditions are limited and becoming crowded. New technologies, such as the circular-track wave pool, are required to provide safe environments for surfing with controllable high quality waves. The research in this proposal will considerably advanc ....The novel production and analysis of breaking waves utilising circular-track moving disturbances. Surfing is a major industry in Australia, contributing $11billion to the economy. It has high active participation levels; but locations with good surfing conditions are limited and becoming crowded. New technologies, such as the circular-track wave pool, are required to provide safe environments for surfing with controllable high quality waves. The research in this proposal will considerably advance knowledge of wave mechanics; provide the ability to design a commercially-viable wave pool and ensure the Australian surfing industry and sport continue to expand. The project will thus result in major scientific, economic and social benefits for Australia.Read moreRead less
The role of turgor in hyphal extension of the Ascomycete Neurospora crassa. Cellular expansion is an absolute necessity during the growth and development of plants and fungi. This process relies heavily upon the accumulation of inorganic ions. Osmotically driven water influx then creates the hydrostatic pressure that underlies the increase in cell volume. Cellular expansion is normally asymmetric and localised in one small region, such as hyphal tip. How does the cell maintain the turgor that dr ....The role of turgor in hyphal extension of the Ascomycete Neurospora crassa. Cellular expansion is an absolute necessity during the growth and development of plants and fungi. This process relies heavily upon the accumulation of inorganic ions. Osmotically driven water influx then creates the hydrostatic pressure that underlies the increase in cell volume. Cellular expansion is normally asymmetric and localised in one small region, such as hyphal tip. How does the cell maintain the turgor that drives expansion? How is expansion controlled spatially? These questions will be addressed in this project by comprehensive study of ion transport processes in a model organism, Neurospora crassa, using osmotic sensitive and transport mutants.Read moreRead less
Outflows, Jets and Plumes. This project studies how fluid flows out from a small concentrated object into a second surrounding fluid. New solution methods will be provided, and new results about how these fluid flows evolve will be obtained. These are important problems with significance in modelling underwater explosions. They are also important in astrophysics, and will help explain the shapes of outflows from some stars or galaxies. The outcomes of the project will be a deeper mathematical un ....Outflows, Jets and Plumes. This project studies how fluid flows out from a small concentrated object into a second surrounding fluid. New solution methods will be provided, and new results about how these fluid flows evolve will be obtained. These are important problems with significance in modelling underwater explosions. They are also important in astrophysics, and will help explain the shapes of outflows from some stars or galaxies. The outcomes of the project will be a deeper mathematical understanding of which outflow shapes are stable, and under what circumstances they might become unstable. This will provide valuable information about galaxy shapes, and a new suite of computational methods for solving such problems.Read moreRead less
Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge mic ....Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge microscopy techniques to visualise whether the endogenous astrocyte protein metallothionein can promote regeneration in the injured nervous system of living zebrafish. The successful outcomes of this project will provide significant insight into understanding how the brain responds to injury.Read moreRead less
Mathematical and computational analysis of ship wakes. This project aims to develop mathematical and computational tools to compute the energy in a given ship wake and to determine a range of properties of a ship by taking simple measurements of the water height as the ship travels past. The expected outcomes of this project include a suite of algorithms that back-calculate the hull shape and operating conditions of a moving ship given only the surface height data measured at a single point. The ....Mathematical and computational analysis of ship wakes. This project aims to develop mathematical and computational tools to compute the energy in a given ship wake and to determine a range of properties of a ship by taking simple measurements of the water height as the ship travels past. The expected outcomes of this project include a suite of algorithms that back-calculate the hull shape and operating conditions of a moving ship given only the surface height data measured at a single point. These results should have direct implications for measuring damage to coastal zones by ship wakes and for surveillance of shipping channels.Read moreRead less
Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-th ....Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-thalassaemia, understanding the specific aHb-binding factor, AHSP is a goal of national significance. In the long term, manipulation of AHSP function through gene therapy may have a direct role in the treatment of thalassaemia.Read moreRead less
Rapid starting and unsteady operation of hydraulic turbines. The project will investigate the ability of hydraulic turbines to start rapidly with the turbine spinning in air which is more water efficient and has lower maintenance costs than other methods. The project will allow higher use of hydroelectricity and higher penetration of wind or other intermittent renewable energy generation into an electricity grid.