Identifying how cortical bone microstructure deteriorates with age. This project aims to define the disruptions responsible for the gradual weakening of the skeleton in ageing by integrating a range of high-resolution imaging, biomechanical, and computational methods. The expected significance of this project includes a full definition and comparison of the cellular and subcellular organisation of bone from young and elderly individuals. Expected outcomes of this international project include th ....Identifying how cortical bone microstructure deteriorates with age. This project aims to define the disruptions responsible for the gradual weakening of the skeleton in ageing by integrating a range of high-resolution imaging, biomechanical, and computational methods. The expected significance of this project includes a full definition and comparison of the cellular and subcellular organisation of bone from young and elderly individuals. Expected outcomes of this international project include the establishment of a new multidisciplinary research team, and the development of a new data-driven theoretical framework for understanding the nature and the causes of age-related bone fragility. Potential long-term benefits include new ways to treat age-related osteoporosis.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100012
Funder
Australian Research Council
Funding Amount
$890,000.00
Summary
Dual Column-Focused Ion Beam/Scanning Electron Microscope facility for Queensland. Dual column focused ion beam/scanning electron microscope facility: This facility will precisely cut specimens and surfaces that can be imaged in a variety of ways, including crystallographic and elemental space, of particular use for physical scientists, as well as biological specimens. This instrument will provide information at resolutions between optical and transmission electron microscopy, images that will ....Dual Column-Focused Ion Beam/Scanning Electron Microscope facility for Queensland. Dual column focused ion beam/scanning electron microscope facility: This facility will precisely cut specimens and surfaces that can be imaged in a variety of ways, including crystallographic and elemental space, of particular use for physical scientists, as well as biological specimens. This instrument will provide information at resolutions between optical and transmission electron microscopy, images that will effectively provide the biologist with the ability to develop the complete correlative picture of organelles and cells. The instrument will also provide a much needed resource for researchers across disciplines such as physics, chemistry, biology, geology and engineering.Read moreRead less
Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to r ....Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100986
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
An innovative platform using non-coding ribonucleic acids (RNAs) to control stem cell differentiation outcomes. It is difficult to control the tissue type that stem cells will form when combined with biomaterials, as the outcome is influenced by the 'stiffness' of the surface to which the stem cells attach. This project will determine how non-coding ribonucleic acids (RNAs) control stem cell behaviours and use this information to direct stem cell differentiation outcomes.