How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Impacts of diet on the brain, body, and microbiome. Dietary habits determine cognitive function, metabolism and the composition of the gut microbiome. This project seeks to clarify the role of the gut microbiome in diet-induced changes to cognition. It aims to do so through longitudinal studies of cognitive function in which dietary patterns are systematically varied, and intervention studies where cognition is tested after experimentally manipulating the gut microbiome. Expected outcomes inclu ....Impacts of diet on the brain, body, and microbiome. Dietary habits determine cognitive function, metabolism and the composition of the gut microbiome. This project seeks to clarify the role of the gut microbiome in diet-induced changes to cognition. It aims to do so through longitudinal studies of cognitive function in which dietary patterns are systematically varied, and intervention studies where cognition is tested after experimentally manipulating the gut microbiome. Expected outcomes include new interdisciplinary knowledge spanning psychology, neuroscience, nutrition and metabolism. This project is timely given the enormous shifts in Australian dietary choices. The knowledge to be gained should provide benefits to individual and public health, agriculture, and food systems.Read moreRead less