Turning back the clock on brain cell aging. This proposal aims to determine the role of fundamental epigenetic mechanisms in the process of aging and whether modulation of the epi-genome underpins an improvement in cognitive function. It combines the fields of epigenetics, neurosciences and mathematics to delineate the dynamics of DNA methylation and histone modification marking on the transcriptome during normal, healthy aging. The outcomes will provide significant new knowledge of the variable ....Turning back the clock on brain cell aging. This proposal aims to determine the role of fundamental epigenetic mechanisms in the process of aging and whether modulation of the epi-genome underpins an improvement in cognitive function. It combines the fields of epigenetics, neurosciences and mathematics to delineate the dynamics of DNA methylation and histone modification marking on the transcriptome during normal, healthy aging. The outcomes will provide significant new knowledge of the variable cognitive decline that occurs in healthy aging and why some populations age less successfully than others do. Better understanding of the impact of environmental change on the biology of aging has potential community benefits.Read moreRead less
Indigenous Lifecourse Research, Data Governance and Capacity Building . This project aims to contribute to rectifying 3 significant gaps in Indigenous research in relation to data; a lack of Indigenous lifecourse research to inform policy development; a lack of Indigenous governance of data; and a broader lack of Indigenous statistical literacy and capability. This project expects to address these gaps: by initiating an Indigenous lifecourse research agenda, using existing datasets; by being th ....Indigenous Lifecourse Research, Data Governance and Capacity Building . This project aims to contribute to rectifying 3 significant gaps in Indigenous research in relation to data; a lack of Indigenous lifecourse research to inform policy development; a lack of Indigenous governance of data; and a broader lack of Indigenous statistical literacy and capability. This project expects to address these gaps: by initiating an Indigenous lifecourse research agenda, using existing datasets; by being the first project to model the application of Indigenous data governance to existing data resources; and by delivering a modularised Indigenous Statistics Course, the first of its kind in Australia, plus a set of statistical literacy workshops to Indigenous organisations to meet Indigenous determined data needs.
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