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Elucidating The Mechanism And Function Of Cell Disassembly During Apoptosis
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
In humans, billions of cells will die daily in various organs as part of normal turnover and disease progression. During cell death, dying cells can disassembly in to smaller fragments, a process that could facilitate their removal, as well as mediate communication with other healthy cells. I aim to understand the machinery that control how dying cells can disassemble into smaller pieces and their function in influenza A infection.
Analysis Of Apoptotic Pathways To Develop Better Therapies For Unresponsive Cancers.
Funder
National Health and Medical Research Council
Funding Amount
$130,807.00
Summary
Tight control of the balance between cellular survival and death is important for normal development and to avoid numerous diseases. Inappropriate survival of precancerous cells can contribute to oncogenesis. Anti-cancer therapies act by inducing a cellular self-destruct program in tumour cells, and blocks in pathways controlling this process can lead to resistance to anti-cancer treatments. Defining cell death pathways will enable the development of better therapies for incurable cancers.
Control Of Organ Size During Development And Disease By The Salvadore-Warts-Hippo Pathway
Funder
National Health and Medical Research Council
Funding Amount
$331,674.00
Summary
Cancer is a disease that results from the generation of too many cells. Many signalling pathways control cell number including the newly identified Salvador-Warts-Hippo pathway. We are studying the mechanisms by which activity of this pathway is controlled, using the vinegar fly as a model. Information obtained from our study will aid understanding of human cancer as cellular processes which go awry in cancer, such as cell proliferation and death, are highly conserved between flies and humans.
Investigating Mitochondrial Outer Membrane Permeabilization During Programmed Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$88,065.00
Summary
Cancer cells often contain defects which prevent their death. To kill cancer cells we must either reset or bypass these defects. Release of cytochrome c from mitochondria is a critical event in cell death and proteins that block this event render cells resistant to many cancer therapies. My research will determine how cytochrome c release occurs, how this event is regulated and how to kill cancer cells in which cytochrome c release is blocked.
The pathology of many acute and chronic diseases associated with the inappropriate activation of genetically encoded programmed cell death pathways, such as sepsis, stroke, diabetes and neurodegeneration, is linked to detrimental inflammation. This project will accurately define at the molecular level how programmed cell death triggers inflammatory responses, and use this knowledge to test novel and next-generation therapeutic strategies in inflammatory-driven diseases.
Generation Of Mouse Models To Study The Roles Of Different Bcl-2 Family Members In The Regulation Of Apaptosis
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
Programmed cell death, or apoptosis, is required for the removal of infected, damaged or unwanted cells and its disrupted regulation is implicated in cancer, autoimmunity and degenerative disorders. The Bcl-2 family of proteins are key regulators of apoptosis. We propose to generate several mouse models to better understand the relationships between the different members of the Bcl-2 family in an effort to control this pathway for therapeutic purposes.