Discovery Early Career Researcher Award - Grant ID: DE180101445
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Structure-based investigations into new modes of action for herbicides. This project aims to focus on identifying and providing protein structure information for new protein targets against which herbicides can be developed. Food security for a growing population relies on agriculture, which in turn relies on herbicides. Presently, herbicide efficacy is under serious threat from resistant weeds. In this project, innovative applications of chemical libraries and exploiting a little-known connect ....Structure-based investigations into new modes of action for herbicides. This project aims to focus on identifying and providing protein structure information for new protein targets against which herbicides can be developed. Food security for a growing population relies on agriculture, which in turn relies on herbicides. Presently, herbicide efficacy is under serious threat from resistant weeds. In this project, innovative applications of chemical libraries and exploiting a little-known connection between plants and human parasites will help to resolve the structure of herbicide targets for the development of new herbicides to ensure future food security.Read moreRead less
Membrane transporters mediating 2,4-D resistance in wild radish. This project aims to identify the membrane transporter protein(s) that endows resistance to the herbicide 2,4-D in wild radish (Raphanus raphanistrum). Wild radish is a particular problem in Australia due to its high competitiveness with crops and widespread resistance to other herbicides. 2,4-D resistance is rapidly increasing and threatening crop production in Australia and the United States. The anticipated outcome of the projec ....Membrane transporters mediating 2,4-D resistance in wild radish. This project aims to identify the membrane transporter protein(s) that endows resistance to the herbicide 2,4-D in wild radish (Raphanus raphanistrum). Wild radish is a particular problem in Australia due to its high competitiveness with crops and widespread resistance to other herbicides. 2,4-D resistance is rapidly increasing and threatening crop production in Australia and the United States. The anticipated outcome of the project is to identify strategies to minimise 2,4-D resistance in wild radish by interfering with the specific transporters that confer resistance and by taking advantage of the fitness cost associated with resistance in some populations. It is expected that this will help to improve crop yields and preserve 2,4-D as an effective herbicide.Read moreRead less
Enhancing Clinical Management Of Paediatric Malaria In Endemic Areas With Transmission Of Multiple Plasmodium Species
Funder
National Health and Medical Research Council
Funding Amount
$867,511.00
Summary
Malaria remains a major problem for children in developing countries especially where different types of the disease are common. This set of complementary studies, based at an established research site in PNG aims to develop new treatment strategies for childhood malaria. A novel method of giving medicine via a spray under the tongue for sick children before arrival at hospital and modified dosing schedules of an old drug used for treating parasites hidden in the liver will be studied.
Smoking Cessation For Youth Project Booster And Cohort Tracking Study
Funder
National Health and Medical Research Council
Funding Amount
$135,550.00
Summary
Adolescence is a critical period for the establishment of adult drug use behaviours. If smoking does not commence in teenage years it is unlikely to occur. This innovative project not only continues to address tobacco control with this important age group but also builds on evidence from a randomised intervention trial involving over 4,000 Year 9 students tracked over two years. This project was called the Smoking Cessation for Youth Project (SCYP). Preliminary longitudinal analyses of the SCYP ....Adolescence is a critical period for the establishment of adult drug use behaviours. If smoking does not commence in teenage years it is unlikely to occur. This innovative project not only continues to address tobacco control with this important age group but also builds on evidence from a randomised intervention trial involving over 4,000 Year 9 students tracked over two years. This project was called the Smoking Cessation for Youth Project (SCYP). Preliminary longitudinal analyses of the SCYP data indicate that the intervention students were significantly less likely to smoke heavily (smoking five or more days per week) than the control group and that intervention students were also significantly less likely to have tried smoking than the control group. These results represent a world first in evidence that population-based smoking cessation interventions among teenagers can be successful. The proposed project will determine the extent to which these positive intervention effects are sustainable, two years post intervention, as our cohort moves into Year 12. In addition to tracking the possible decay of SCYP intervention effects, the proposed project will also measure the effects of a booster intervention delivered students when they are in Year 12 (2002). The Year 12 intervention will comprise an innovative self-help 'magazine style' booster and a supportive environmental intervention involving school nurses and local GPs. This proposal represents a cost-effective opportunity to measure the effectiveness of a Year 12 tobacco cessation booster intervention. Further data on tobacco smoking behaviour in 2002 will also enable us to determine how long the SCYP intervention appears to affect behaviour and whether 'boosters' are needed in later secondary school years to maintain the benefits.Read moreRead less
In touch with the environment: dissecting early tactile responses in plants. This project aims to identify the regulatory mechanisms that control touch-responses in plants. Although plants cannot relocate in the face of danger, they are able to sense mechanical manipulations from the environment. These could be caused by pathogens, herbivores, rain or even wind. This touch-responsiveness of plants is essential for pathogen resistance and for triggering architectural changes to overcome obstacles ....In touch with the environment: dissecting early tactile responses in plants. This project aims to identify the regulatory mechanisms that control touch-responses in plants. Although plants cannot relocate in the face of danger, they are able to sense mechanical manipulations from the environment. These could be caused by pathogens, herbivores, rain or even wind. This touch-responsiveness of plants is essential for pathogen resistance and for triggering architectural changes to overcome obstacles and prevent mechanical damage. Using a comprehensive tool set of genetics, genomics and proteomics, this project aims to identify the upstream regulators that control touch responses. Furthermore, it is expected to expand our understanding of the physiological impacts of touch-responses on growth and stress tolerance.Read moreRead less
Identifying the biochemical and molecular bases of 2,4-D herbicide resistance in the economically important weed Raphanus raphanistrum (wild radish). An alarming increase in the incidence of field-evolved resistance to 2,4-D in Australian wild radish has recently been observed. The project aims to characterise the molecular and biochemical mechanism(s) of resistance to help minimise its impact on Australian cropping.
Putting new herbicide targets on the table. This project aims to discover plant processes and plant proteins that can be the target for new herbicides. Australia's food security is being threatened by a rise in resistance to herbicides, the chemicals relied on to control weeds. In over 20 years a truly new herbicide has not appeared. This project aims to provide validated new targets to engage agrochemical industry and accelerate the rate farmers get tools to manage problematic weeds, the major ....Putting new herbicide targets on the table. This project aims to discover plant processes and plant proteins that can be the target for new herbicides. Australia's food security is being threatened by a rise in resistance to herbicides, the chemicals relied on to control weeds. In over 20 years a truly new herbicide has not appeared. This project aims to provide validated new targets to engage agrochemical industry and accelerate the rate farmers get tools to manage problematic weeds, the major yield penalty for both developed and developing world agriculture. The project expects enable effective collaboration with industry to develop new herbicides.Read moreRead less
Modelling and estimation methods for discrete multi-dimensional systems. Multi-dimensional signal processing plays a role in a variety of application areas, ranging from remote sensing for environmental monitoring and geological mapping, to medical imaging and the automatic control of industrial processes. The success of the project will provide mathematical tools for the advancement of the state-of-the-art in these broad areas.
Re-uniting marsupials and eutherians by embryonic micromanipulation. The unique responsibility for transmitting life from generation to generation normally depends on the gametes. This project will use new reproductive technologies to investigate the properties of the oocyte in reprogramming somatic cell nuclei, and will use the nuclei of both marsupial and eutherian somatic cells to test this. We will also use both marsupial and eutherian genes to insert into the oocyte to create the first tra ....Re-uniting marsupials and eutherians by embryonic micromanipulation. The unique responsibility for transmitting life from generation to generation normally depends on the gametes. This project will use new reproductive technologies to investigate the properties of the oocyte in reprogramming somatic cell nuclei, and will use the nuclei of both marsupial and eutherian somatic cells to test this. We will also use both marsupial and eutherian genes to insert into the oocyte to create the first transgenic marsupials. We will also investigate the ability of spermatozoa from species of increasing genetic distance to ferttilise marsupial eggs using intracytoplasmic sperm injection (ICSI).Read moreRead less