The Cytochrome P450 Gene Super-family in Drosophila melanogaster; Gene Function and Insecticide Resistance. The cytochrome P450 (Cyp) gene super-family is represented by over 90 sequences in the genome of the vinegar fly, Drosophila melanogaster. To date, four Cyp genes are found to be involved in insecticide resistance. The function of the majority of Cyp genes is unknown. This project will investigate the function and regulation of D. melanogaster Cyp genes, linking the fly's genotype to its ....The Cytochrome P450 Gene Super-family in Drosophila melanogaster; Gene Function and Insecticide Resistance. The cytochrome P450 (Cyp) gene super-family is represented by over 90 sequences in the genome of the vinegar fly, Drosophila melanogaster. To date, four Cyp genes are found to be involved in insecticide resistance. The function of the majority of Cyp genes is unknown. This project will investigate the function and regulation of D. melanogaster Cyp genes, linking the fly's genotype to its phenotype. By studying the effects of Cyp genes on fly survival, Cyp gene expression and regulation, and expressing selected Cyp genes in a yeast expression system, we will enhance our understanding of Cyp gene function and evolution.Read moreRead less
Co-design and dynamic mission optimisation of hypersonic flight vehicles. This project aims to deliver fundamental knowledge by integrating the modelling and control with the design of next generation hypersonic platforms. In an era where Australia's national security reliance on geographic isolation and support from allied forces are being challenged, the research outcomes of this project will play an important role in understanding the capabilities of hypersonic systems. The project will also ....Co-design and dynamic mission optimisation of hypersonic flight vehicles. This project aims to deliver fundamental knowledge by integrating the modelling and control with the design of next generation hypersonic platforms. In an era where Australia's national security reliance on geographic isolation and support from allied forces are being challenged, the research outcomes of this project will play an important role in understanding the capabilities of hypersonic systems. The project will also have significant spillover benefits into other complex system domains, where computational tools can be used to aid in design leading to high embedded-IP products for Australian industry. Furthermore, the proposal encompasses a strong research training aspect, with graduates exposed to leading edge industry and academia.Read moreRead less
Role of Musashi in the regulation of cell cycle proteins. We have identified a protein family that directs cell fate and maintains male fertility. This project will provide new avenues for generation of contraceptives in male animals and to regulate stem cells for production of specialised cell types in biotechnological applications.
ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology indust ....ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology industry, the protection of the Australian Environment and the well-being of the Australian people. Key issues for this Centre include testicular cancer, male infertility, contraception, pest animal control, environmental impacts on human health and gene pharming.Read moreRead less
Renewable energy generation from flow-induced vibration. Much engineering effort has been expended to eliminate vibration of marine structures. This project seeks to provide the basis for the development of tidal energy harnessing, by deliberately amplifying and harnessing vibration. This technology offers the promise of capturing clean, zero-emissions energy, while presenting no risk to marine life.
The social determinants of childhood injury. Child hood injury is a preventable problem of major importance. This project will provide a comprehensive, research-based policy solution that will minimise death and disability among children zero to three years of age.
Development of Control Methodologies for Drug Dosing in Biomedical Engineering. This research proposal is very relevant to the National Research Priorities in the areas of Frontier Technologies and Breakthrough science. At a broader level, we aim to assist in the development of a national competence in what has been an emerging and promising discipline. The research will develop fundamental and enabling laws and techniques for drug administration to regulate physiological variables such as blood ....Development of Control Methodologies for Drug Dosing in Biomedical Engineering. This research proposal is very relevant to the National Research Priorities in the areas of Frontier Technologies and Breakthrough science. At a broader level, we aim to assist in the development of a national competence in what has been an emerging and promising discipline. The research will develop fundamental and enabling laws and techniques for drug administration to regulate physiological variables such as blood pressure and degree of consciousness in critical care patients.Read moreRead less
Automatic control systems for low-energy pipelines in irrigation networks. Automatic control systems for low-energy pipelines in irrigation networks. This project aims to design automated pipelines to distribute irrigation water from backbone open-channels to end-users. Automation can make irrigation networks more efficient, which is important for food security and the environment. Automation is expected to achieve low-energy distribution, in line with the gravity-powered operation of typical op ....Automatic control systems for low-energy pipelines in irrigation networks. Automatic control systems for low-energy pipelines in irrigation networks. This project aims to design automated pipelines to distribute irrigation water from backbone open-channels to end-users. Automation can make irrigation networks more efficient, which is important for food security and the environment. Automation is expected to achieve low-energy distribution, in line with the gravity-powered operation of typical open-channel networks. The main challenges are the development of suitable models for designing outlet-flow control systems, optimization-based outlet-flow scheduling methods for ensuring operation within hydraulic constraints, and system monitoring techniques. This project will design automatic control systems to enable low-energy water distribution from open-channels to end-users by pipes.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100003
Funder
Australian Research Council
Funding Amount
$4,930,205.00
Summary
ARC Training Centre for Biofilm Research and Innovation . The ARC Training Centre for Biofilm Research and Innovation aims to transform biofouling management strategies for maritime platforms by building on local and international expertise to mentor and train the next generation of interdisciplinary scientists and engineers. Anticipating evolving regulatory stringency, this project expects to establish a dynamic environment for industry partners, students and scientists to collaborate and devel ....ARC Training Centre for Biofilm Research and Innovation . The ARC Training Centre for Biofilm Research and Innovation aims to transform biofouling management strategies for maritime platforms by building on local and international expertise to mentor and train the next generation of interdisciplinary scientists and engineers. Anticipating evolving regulatory stringency, this project expects to establish a dynamic environment for industry partners, students and scientists to collaborate and develop biofilm management strategies. Expected outcomes include new and enhanced collaborations that advance and translate knowledge to better manage biofouling. The significant benefits will include a generation of industry-focused researchers critical for growing Australia’s Defence industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100041
Funder
Australian Research Council
Funding Amount
$680,320.00
Summary
National laser-based non-destructive evaluation system. This project aims to establish the first Australian national facility for non-destructive evaluation, consisting of a three-dimensional scanning laser vibrometer, laser shearography, and an optical de-rotator, to enable full-field characterisation of the deformation and damage state of materials and structures. This solution is expected to perform rapid, broad-area scans, characterise dynamic response and wave propagation in human-engineere ....National laser-based non-destructive evaluation system. This project aims to establish the first Australian national facility for non-destructive evaluation, consisting of a three-dimensional scanning laser vibrometer, laser shearography, and an optical de-rotator, to enable full-field characterisation of the deformation and damage state of materials and structures. This solution is expected to perform rapid, broad-area scans, characterise dynamic response and wave propagation in human-engineered or natural structures, and diagnose rotating systems. This will enhance experimental capabilities, with uses spanning many industry sectors including aerospace, naval, automotive and medical.Read moreRead less