The Cytochrome P450 Gene Super-family in Drosophila melanogaster; Gene Function and Insecticide Resistance. The cytochrome P450 (Cyp) gene super-family is represented by over 90 sequences in the genome of the vinegar fly, Drosophila melanogaster. To date, four Cyp genes are found to be involved in insecticide resistance. The function of the majority of Cyp genes is unknown. This project will investigate the function and regulation of D. melanogaster Cyp genes, linking the fly's genotype to its ....The Cytochrome P450 Gene Super-family in Drosophila melanogaster; Gene Function and Insecticide Resistance. The cytochrome P450 (Cyp) gene super-family is represented by over 90 sequences in the genome of the vinegar fly, Drosophila melanogaster. To date, four Cyp genes are found to be involved in insecticide resistance. The function of the majority of Cyp genes is unknown. This project will investigate the function and regulation of D. melanogaster Cyp genes, linking the fly's genotype to its phenotype. By studying the effects of Cyp genes on fly survival, Cyp gene expression and regulation, and expressing selected Cyp genes in a yeast expression system, we will enhance our understanding of Cyp gene function and evolution.Read moreRead less
Role of Musashi in the regulation of cell cycle proteins. We have identified a protein family that directs cell fate and maintains male fertility. This project will provide new avenues for generation of contraceptives in male animals and to regulate stem cells for production of specialised cell types in biotechnological applications.
ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology indust ....ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology industry, the protection of the Australian Environment and the well-being of the Australian people. Key issues for this Centre include testicular cancer, male infertility, contraception, pest animal control, environmental impacts on human health and gene pharming.Read moreRead less
Renewable energy generation from flow-induced vibration. Much engineering effort has been expended to eliminate vibration of marine structures. This project seeks to provide the basis for the development of tidal energy harnessing, by deliberately amplifying and harnessing vibration. This technology offers the promise of capturing clean, zero-emissions energy, while presenting no risk to marine life.
The social determinants of childhood injury. Child hood injury is a preventable problem of major importance. This project will provide a comprehensive, research-based policy solution that will minimise death and disability among children zero to three years of age.
Development of Control Methodologies for Drug Dosing in Biomedical Engineering. This research proposal is very relevant to the National Research Priorities in the areas of Frontier Technologies and Breakthrough science. At a broader level, we aim to assist in the development of a national competence in what has been an emerging and promising discipline. The research will develop fundamental and enabling laws and techniques for drug administration to regulate physiological variables such as blood ....Development of Control Methodologies for Drug Dosing in Biomedical Engineering. This research proposal is very relevant to the National Research Priorities in the areas of Frontier Technologies and Breakthrough science. At a broader level, we aim to assist in the development of a national competence in what has been an emerging and promising discipline. The research will develop fundamental and enabling laws and techniques for drug administration to regulate physiological variables such as blood pressure and degree of consciousness in critical care patients.Read moreRead less
Automatic control systems for low-energy pipelines in irrigation networks. Automatic control systems for low-energy pipelines in irrigation networks. This project aims to design automated pipelines to distribute irrigation water from backbone open-channels to end-users. Automation can make irrigation networks more efficient, which is important for food security and the environment. Automation is expected to achieve low-energy distribution, in line with the gravity-powered operation of typical op ....Automatic control systems for low-energy pipelines in irrigation networks. Automatic control systems for low-energy pipelines in irrigation networks. This project aims to design automated pipelines to distribute irrigation water from backbone open-channels to end-users. Automation can make irrigation networks more efficient, which is important for food security and the environment. Automation is expected to achieve low-energy distribution, in line with the gravity-powered operation of typical open-channel networks. The main challenges are the development of suitable models for designing outlet-flow control systems, optimization-based outlet-flow scheduling methods for ensuring operation within hydraulic constraints, and system monitoring techniques. This project will design automatic control systems to enable low-energy water distribution from open-channels to end-users by pipes.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100041
Funder
Australian Research Council
Funding Amount
$680,320.00
Summary
National laser-based non-destructive evaluation system. This project aims to establish the first Australian national facility for non-destructive evaluation, consisting of a three-dimensional scanning laser vibrometer, laser shearography, and an optical de-rotator, to enable full-field characterisation of the deformation and damage state of materials and structures. This solution is expected to perform rapid, broad-area scans, characterise dynamic response and wave propagation in human-engineere ....National laser-based non-destructive evaluation system. This project aims to establish the first Australian national facility for non-destructive evaluation, consisting of a three-dimensional scanning laser vibrometer, laser shearography, and an optical de-rotator, to enable full-field characterisation of the deformation and damage state of materials and structures. This solution is expected to perform rapid, broad-area scans, characterise dynamic response and wave propagation in human-engineered or natural structures, and diagnose rotating systems. This will enhance experimental capabilities, with uses spanning many industry sectors including aerospace, naval, automotive and medical.Read moreRead less
Mediator: a new concept for controlled gene expression in plant biotechnology. The Mediator protein complex is a new control point for the activation of all genes in higher organisms and the purpose of this project is to understand how three Mediator subunits regulate disease resistance in plants. The outcomes provide a new concept to direct natural gene expression towards robust crop plants able to cope with climatic variations.
TELEPHONE COUNSELLING FOR MAINTENANCE OF PHYSICAL ACTIVITY, WEIGHT LOSS And GLYCAEMIC CONTROL IN TYPE 2 DIABETES
Funder
National Health and Medical Research Council
Funding Amount
$1,285,894.00
Summary
Regular exercise, a healthy diet and weight loss are key to managing type 2 diabetes, yet these are major challenges for most people with diabetes. This study will evaluate the impact of a telephone counselling program to assist people with type 2 diabetes to exercise, eat a healthy diet and lose weight, with the goal of helping them to sustain these changes over the long-term. It is expected that these lifestyle changes will also result in improved blood glucose control and quality of life.