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Analysing and disrupting outlaw motorcycle gangs in Australia. This project aims to reveal the structure and social dynamics of co-offending networks by OMCGs in Australia. Outlaw motorcycle gangs (OMCGs) cause significant social and economic harm in Australia and internationally. The project will generate new knowledge about OMCG co-offending using an innovative multimethod approach combining social network analysis with interviews and focus groups. Expected outcomes include a deeper understand ....Analysing and disrupting outlaw motorcycle gangs in Australia. This project aims to reveal the structure and social dynamics of co-offending networks by OMCGs in Australia. Outlaw motorcycle gangs (OMCGs) cause significant social and economic harm in Australia and internationally. The project will generate new knowledge about OMCG co-offending using an innovative multimethod approach combining social network analysis with interviews and focus groups. Expected outcomes include a deeper understanding of OMCG criminal activity across Australia and refined theory development about co-offending in criminal groups. The project will lead to improved policy, legislation and policing practice to prevent OMCG crime and dismantle OMCG criminal networks in more cost-effective ways.Read moreRead less
Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to de ....Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to develop services and interventions aimed at preventing young people from becoming enmeshed in the criminal justice system.Read moreRead less
Understanding the emerging threat of conspiracy-fuelled extremism. This project aims to address the emerging threat of conspiracy-fuelled extremism in Australia. The project expects to produce new knowledge by identifying the unique factors driving this new form of extremism and the social harm it causes. Through three studies, the project will test a new theoretical model of conspiracy-fuelled extremism, will explore the threats and social harms this form of extremism creates, and will develop ....Understanding the emerging threat of conspiracy-fuelled extremism. This project aims to address the emerging threat of conspiracy-fuelled extremism in Australia. The project expects to produce new knowledge by identifying the unique factors driving this new form of extremism and the social harm it causes. Through three studies, the project will test a new theoretical model of conspiracy-fuelled extremism, will explore the threats and social harms this form of extremism creates, and will develop evidence-based insights into how it can be mitigated. The research should produce benefits for Australia by providing policymakers with a risk-assessment tool to identify individuals most 'at-risk' of violent extremism, and by providing knowledge about the services families may require to de-radicalise loved ones.Read moreRead less
Differential roles of gene family members in development of a cell lineage. This project aims to investigate how a family of genes influence cells in the testis to become mature sperm. Testicular cells regulate gene activity via the Snail family of proteins during sperm development, and interruption of their activities reduces fertility in mice and fruit flies. The project aims to use genetic, cell biological and biochemical studies in Drosophila and mice to compare different Snail family protei ....Differential roles of gene family members in development of a cell lineage. This project aims to investigate how a family of genes influence cells in the testis to become mature sperm. Testicular cells regulate gene activity via the Snail family of proteins during sperm development, and interruption of their activities reduces fertility in mice and fruit flies. The project aims to use genetic, cell biological and biochemical studies in Drosophila and mice to compare different Snail family proteins in spermatogenesis. The outcomes will define the different roles of highly similar proteins from the same family in differentiation of a single cell lineage. This is important in generating functional tissues using in vitro laboratory approaches or understanding how normal development and developmental disorders arise.Read moreRead less
Understanding and preventing gun violence: A qualitative study. Gun violence causes significant harm across Australian communities. Excluding sexual assault, firearms feature in nearly one in 10 violent crimes. The annual costs of gun violence run into tens of millions of dollars. This project aims to make an original qualitative contribution to understanding and preventing gun violence in three contexts: drug dealing/trafficking, other organised crime activity, and armed robbery. The proposed r ....Understanding and preventing gun violence: A qualitative study. Gun violence causes significant harm across Australian communities. Excluding sexual assault, firearms feature in nearly one in 10 violent crimes. The annual costs of gun violence run into tens of millions of dollars. This project aims to make an original qualitative contribution to understanding and preventing gun violence in three contexts: drug dealing/trafficking, other organised crime activity, and armed robbery. The proposed research would be the first study nationally - and one of the very few internationally - to interview convicted gun crime users about the acquisition and use of firearms in criminal life. Project results are expected to have direct implications for reducing the impact of gun violence in Australia.Read moreRead less
Understanding the potency and role of individual stem cells in the skin using Rainbow technology. To renew itself, the skin and its components rely on the activity of stem cells. This project will define more precisely the role of each individual stem cell by labelling them with a unique colour and following its fate. This project has the potential to change our current view on how the skin maintains and repairs itself.
Signaling in the crypt: a novel metabolic pathway in intestinal stem cells. The gut is the most rapidly renewing tissue in the body, driven by a highly active stem cell niche. Bile acids are emerging as critical regulators of this stem cell niche and disruption of bile acid homeostasis has profoundly adverse effects on intestinal renewal and hence gut health. We are addressing a critical gap in our understanding of how bile acids are controlled within stem cell niche. The aim of the project is ....Signaling in the crypt: a novel metabolic pathway in intestinal stem cells. The gut is the most rapidly renewing tissue in the body, driven by a highly active stem cell niche. Bile acids are emerging as critical regulators of this stem cell niche and disruption of bile acid homeostasis has profoundly adverse effects on intestinal renewal and hence gut health. We are addressing a critical gap in our understanding of how bile acids are controlled within stem cell niche. The aim of the project is to define the critical role of a novel enzyme called UGT8 in controlling intestinal stem cell response to bile acids; this is achieved by modulating UGT8 activity in intestinal stem cell models and determining the effects on stem cell function and the key signalling pathways that control intestinal homeostasis and renewal.Read moreRead less
Unravelling the complexities of cell death pathways . This project aims to test if cells can flexibly rewire their cell death pathways to ensure that the absence or inhibition of one type of cell death can be compensated through the triggering of another. The project expects to generate new knowledge in the area of programed cell death, and more specifically will address why cells have multiple programmed ways to die. Expected outcomes of this project include the provision of unprecedented insig ....Unravelling the complexities of cell death pathways . This project aims to test if cells can flexibly rewire their cell death pathways to ensure that the absence or inhibition of one type of cell death can be compensated through the triggering of another. The project expects to generate new knowledge in the area of programed cell death, and more specifically will address why cells have multiple programmed ways to die. Expected outcomes of this project include the provision of unprecedented insights into the molecular regulation of how cells orchestrate and integrate cell death pathways. This should provide significant benefits, such as providing the knowledge base needed to improve our abilities to manipulate cell death both in basic research and commercial applications of cell death.Read moreRead less
Domestic violence disclosure schemes: A national review. In 2014 family violence was declared a national emergency in Australia. In the years since there has been extensive law reform activity. Domestic violence disclosure schemes have emerged within this context as a policy option that may improve safety outcomes for victims. However, there is currently no evidence as to the impact of these schemes and no consultation with victims as to their value. This project aims to generate the evidence re ....Domestic violence disclosure schemes: A national review. In 2014 family violence was declared a national emergency in Australia. In the years since there has been extensive law reform activity. Domestic violence disclosure schemes have emerged within this context as a policy option that may improve safety outcomes for victims. However, there is currently no evidence as to the impact of these schemes and no consultation with victims as to their value. This project aims to generate the evidence required to inform decisions about the introduction of these schemes, to better understand what victim/survivors want from them, and how such schemes can be effectively operationalised. The findings seek to be relevant to all Australian states and territories as well as international jurisdictions.Read moreRead less
Preventing intimate partner homicide. The project aims to develop a framework for an integrated whole systems preventive approach to intimate partner homicide – the most common type of violence against women worldwide and the leading cause of death amongst Australian women aged between 15 and 44. The project will review a decade of intimate partner homicides in Australia to identify points of intervention that might have prevented killings. This knowledge is intended to inform and help develop a ....Preventing intimate partner homicide. The project aims to develop a framework for an integrated whole systems preventive approach to intimate partner homicide – the most common type of violence against women worldwide and the leading cause of death amongst Australian women aged between 15 and 44. The project will review a decade of intimate partner homicides in Australia to identify points of intervention that might have prevented killings. This knowledge is intended to inform and help develop a more risk-sensitive preventive approach to intimate partner homicides in Australia and overseas, enhancing women’s security and preventing their deaths.Read moreRead less