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Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to de ....Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to develop services and interventions aimed at preventing young people from becoming enmeshed in the criminal justice system.Read moreRead less
Understanding the emerging threat of conspiracy-fuelled extremism. This project aims to address the emerging threat of conspiracy-fuelled extremism in Australia. The project expects to produce new knowledge by identifying the unique factors driving this new form of extremism and the social harm it causes. Through three studies, the project will test a new theoretical model of conspiracy-fuelled extremism, will explore the threats and social harms this form of extremism creates, and will develop ....Understanding the emerging threat of conspiracy-fuelled extremism. This project aims to address the emerging threat of conspiracy-fuelled extremism in Australia. The project expects to produce new knowledge by identifying the unique factors driving this new form of extremism and the social harm it causes. Through three studies, the project will test a new theoretical model of conspiracy-fuelled extremism, will explore the threats and social harms this form of extremism creates, and will develop evidence-based insights into how it can be mitigated. The research should produce benefits for Australia by providing policymakers with a risk-assessment tool to identify individuals most 'at-risk' of violent extremism, and by providing knowledge about the services families may require to de-radicalise loved ones.Read moreRead less
Understanding the potency and role of individual stem cells in the skin using Rainbow technology. To renew itself, the skin and its components rely on the activity of stem cells. This project will define more precisely the role of each individual stem cell by labelling them with a unique colour and following its fate. This project has the potential to change our current view on how the skin maintains and repairs itself.
Targeting mitochondria with mitocans to treat cancer: mechanistic aspects. Mitochondria are the power-house of the cell and also the reservoir of proteins causing the demise of cancer cells, therefore suppressing tumour progression. This project proposes a novel way to modify certain compounds, increasing their level in mitochondria in order to maximise their anti-cancer effect.
Microenvironments which support extramedullary hematopoiesis. Tissue regeneration is a breakthrough technology absolutely dependent on knowledge of the stem cells and stromal cells which support differentiation and tissue development. This project investigates the stromal cell types in spleen which can regenerate blood-forming cells in an ectopic tissue site or artificial matrix.
Role of senataxin protein in meiotic recombination and sex chromosome inactivation. Senataxin is a protein defective in the human genetic disorder ataxia oculomotor apraxia type 2. This project is designed to carry out mechanistic studies on the protein to establish its normal role in the cell.
Into the thirties: Persistence and social consequences of risky drinking. The aim of this project is to investigate the social contexts, roles and consequences of problematic alcohol use in adults aged 30, using long term longitudinal resources able to observe the development and corollary of alcohol use over time. It is posited that such drinkers entering their third decade of life persist in levels of problematic alcohol use typically associated with younger ages and that this leads to social ....Into the thirties: Persistence and social consequences of risky drinking. The aim of this project is to investigate the social contexts, roles and consequences of problematic alcohol use in adults aged 30, using long term longitudinal resources able to observe the development and corollary of alcohol use over time. It is posited that such drinkers entering their third decade of life persist in levels of problematic alcohol use typically associated with younger ages and that this leads to social consequences, such as gender specific risks, relationship conflicts and more severe long term effects. Outcomes from this project are expected to inform the generation of relevant prevention and intervention strategies aimed to address problem drinking in adult Australians.Read moreRead less
Pyroptotic macrophages posthumously sculpt immune responses. The life of an organism relies on the timely birth and death of its cells. Importantly, it is crucial for cells to die not only at the right time, but also in an appropriate manner. This proposal investigates a cell death pathway that triggers potent immune responses. This proposal seeks to reveal precisely how cell death sculpts immune responses. Expected outcomes include new insights into how immune cells die, and how they instruct i ....Pyroptotic macrophages posthumously sculpt immune responses. The life of an organism relies on the timely birth and death of its cells. Importantly, it is crucial for cells to die not only at the right time, but also in an appropriate manner. This proposal investigates a cell death pathway that triggers potent immune responses. This proposal seeks to reveal precisely how cell death sculpts immune responses. Expected outcomes include new insights into how immune cells die, and how they instruct immune responses from beyond the grave. Project benefits include a fundamental understanding of how cell death signalling sculpts tissue immune responses, and knowledge of how to manipulate cell death responses for future basic research and commercial applications beyond this project.Read moreRead less
Lifting the burden of imprisonment: Creating safer and stronger communities. This project aims to identify how a reduction in imprisonment rates could benefit Australian communities and enhance their safety and wellbeing. It will link a range of statistical data sources on imprisonment, crime and community wellbeing. We will, for the first time, comprehensively demonstrate the impact of imprisonment on individuals and communities in Australia and beyond. Expected outcomes of this project include ....Lifting the burden of imprisonment: Creating safer and stronger communities. This project aims to identify how a reduction in imprisonment rates could benefit Australian communities and enhance their safety and wellbeing. It will link a range of statistical data sources on imprisonment, crime and community wellbeing. We will, for the first time, comprehensively demonstrate the impact of imprisonment on individuals and communities in Australia and beyond. Expected outcomes of this project include expansion and innovation of coercive mobility theory, novel integration of data, and a forecasting tool to assess the impact of imprisonment reduction on communities. This evidence will assist advocacy groups and policy makers seeking to address Australia’s burgeoning imprisonment rate.Read moreRead less
Identifying novel, health-related predictors of recidivism: Informing evidence-based throughcare. Throughcare is a policy priority for correctional authorities in Australia, however the evidence base to inform policy is limited. Using innovative modelling techniques and unique data from a large, representative cohort of ex-prisoners in Queensland, this study will: identify novel, health-related predictors of recidivism in the first two years after release from adult custody; examine the extent t ....Identifying novel, health-related predictors of recidivism: Informing evidence-based throughcare. Throughcare is a policy priority for correctional authorities in Australia, however the evidence base to inform policy is limited. Using innovative modelling techniques and unique data from a large, representative cohort of ex-prisoners in Queensland, this study will: identify novel, health-related predictors of recidivism in the first two years after release from adult custody; examine the extent to which risk and protective factors for recidivism vary over time and according to individual characteristics; and, provide evidence-based recommendations to improve throughcare interventions and reduce recidivism.Read moreRead less