The lipidomics of cell fate. This project aims to dissect the roles of lipids in cell fate. The study of lipids, or lipidomics, is an emerging and exciting area of biological science. The fundamental roles of lipids in development remain vastly understudied. This project will look at reprogramming of somatic cells into stem cells, their pluripotency and differentiation. This will be complemented with studies in the zebrafish, which permits the direct study of cell fate in vivo. This approach is ....The lipidomics of cell fate. This project aims to dissect the roles of lipids in cell fate. The study of lipids, or lipidomics, is an emerging and exciting area of biological science. The fundamental roles of lipids in development remain vastly understudied. This project will look at reprogramming of somatic cells into stem cells, their pluripotency and differentiation. This will be complemented with studies in the zebrafish, which permits the direct study of cell fate in vivo. This approach is a powerful way to unlock major events involved in development and to unmask the roles of lipids in these fundamental mechanisms.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100012
Funder
Australian Research Council
Funding Amount
$890,000.00
Summary
Dual Column-Focused Ion Beam/Scanning Electron Microscope facility for Queensland. Dual column focused ion beam/scanning electron microscope facility: This facility will precisely cut specimens and surfaces that can be imaged in a variety of ways, including crystallographic and elemental space, of particular use for physical scientists, as well as biological specimens. This instrument will provide information at resolutions between optical and transmission electron microscopy, images that will ....Dual Column-Focused Ion Beam/Scanning Electron Microscope facility for Queensland. Dual column focused ion beam/scanning electron microscope facility: This facility will precisely cut specimens and surfaces that can be imaged in a variety of ways, including crystallographic and elemental space, of particular use for physical scientists, as well as biological specimens. This instrument will provide information at resolutions between optical and transmission electron microscopy, images that will effectively provide the biologist with the ability to develop the complete correlative picture of organelles and cells. The instrument will also provide a much needed resource for researchers across disciplines such as physics, chemistry, biology, geology and engineering.Read moreRead less
Subcellular recruitment of a RhoA ubiquitination complex by Rnd proteins. This study addresses a novel molecular mechanism through which members of the Rnd family of GTP-binding proteins regulate the morphology and migration of immature nerve cells of the developing nervous system. This study has broad implications for the understanding of cell migration during embryo development, as well as in health and disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100066
Funder
Australian Research Council
Funding Amount
$440,000.00
Summary
Mass Cytometry: A breakthrough in multidimensional systems biology. Mass cytometry - a breakthrough in multidimensional systems biology: Mass Cytometry by Time of Flight marries the resolution, specificity and sensitivity of atomic stable isotope mass spectrometry to the high-throughput, single-cell analytical advantages of flow cytometry. Using molecular probes conjugated with stable isotope tags, a large increase is possible in the number of simultaneous quantitative measurements in complex sa ....Mass Cytometry: A breakthrough in multidimensional systems biology. Mass cytometry - a breakthrough in multidimensional systems biology: Mass Cytometry by Time of Flight marries the resolution, specificity and sensitivity of atomic stable isotope mass spectrometry to the high-throughput, single-cell analytical advantages of flow cytometry. Using molecular probes conjugated with stable isotope tags, a large increase is possible in the number of simultaneous quantitative measurements in complex samples. These parameters, denoting cell type, function and signalling status, will make possible future advances in the understanding of the diversity of cell phenotype and function with a systems biology approach. Read moreRead less
Multi-object Estimation for Live-Cell Microscopy. The objective of this project is to develop new tools for the inference of biological information from live-cell data to facilitate analysis of experiments and speed up discovery in cell biology. The new tools would provide reliable, consistent inference requiring no manual intervention and able to process large volumes of data in a timely manner. This would equip biologists with a vehicle that could move them closer to the goal of understanding ....Multi-object Estimation for Live-Cell Microscopy. The objective of this project is to develop new tools for the inference of biological information from live-cell data to facilitate analysis of experiments and speed up discovery in cell biology. The new tools would provide reliable, consistent inference requiring no manual intervention and able to process large volumes of data in a timely manner. This would equip biologists with a vehicle that could move them closer to the goal of understanding the mechanism behind biological processes.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100001
Funder
Australian Research Council
Funding Amount
$875,000.00
Summary
A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected out ....A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected outcomes to include the generation of new knowledge of major biological systems, including the immune system and the nervous system. This will provide significant benefits to fundamental interdisciplinary research into immunology, infectious disease, neuroscience, mechanobiology and engineering.Read moreRead less
The philosophical foundations of women’s rights: a new history, 1600-1750. This project aims to show that the history of women’s rights is much longer and richer than previously thought. There is a common perception that the notion of women’s rights first emerged in the late eighteenth century. This project expects to generate a new understanding of feminist history by investigating texts calling for the recognition of women’s dignity, worth, nobility, and excellence (cognate concepts to rights) ....The philosophical foundations of women’s rights: a new history, 1600-1750. This project aims to show that the history of women’s rights is much longer and richer than previously thought. There is a common perception that the notion of women’s rights first emerged in the late eighteenth century. This project expects to generate a new understanding of feminist history by investigating texts calling for the recognition of women’s dignity, worth, nobility, and excellence (cognate concepts to rights) in England and Europe from 1600 to 1750, against the backdrop of the rise of Cartesianism. The anticipated outcome is greater awareness of an enduring feminist tradition within the history of philosophy. The expected social benefits include a shift in public thinking about feminist history and women in philosophy.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100458
Funder
Australian Research Council
Funding Amount
$444,662.00
Summary
Understanding the role of cosmeceuticals in health, gender and ageing. Cosmeceuticals are a new category of product at the intersection of cosmetics and pharmaceuticals taken to prevent and treat the physical signs of ageing. This project aims to investigate the advertising, regulation and use of cosmeceuticals, drawing on an innovative theoretical approach and qualitative methods. This project expects to generate new knowledge on the relationship between cosmeceuticals and contemporary experien ....Understanding the role of cosmeceuticals in health, gender and ageing. Cosmeceuticals are a new category of product at the intersection of cosmetics and pharmaceuticals taken to prevent and treat the physical signs of ageing. This project aims to investigate the advertising, regulation and use of cosmeceuticals, drawing on an innovative theoretical approach and qualitative methods. This project expects to generate new knowledge on the relationship between cosmeceuticals and contemporary experiences of health, ageing and gender. Expected outcomes include recommendations to improve healthcare and regulation and public outputs to help consumers navigate anti-ageing imperatives. This should provide significant benefit by reducing consumer harms and the associated social, health and economic consequences.Read moreRead less
Exemplary early childhood educators at work: A multi-level investigation. Exemplary early childhood educators at work: A multi-level investigation. This project aims to inform strategies to better attract, prepare, recognise, support and retain a high quality workforce, by investigating the complexity of early childhood educators’ work. Seemingly entrenched workforce shortages threaten the objectives that governments and families seek through investment in early childhood education. Popular imag ....Exemplary early childhood educators at work: A multi-level investigation. Exemplary early childhood educators at work: A multi-level investigation. This project aims to inform strategies to better attract, prepare, recognise, support and retain a high quality workforce, by investigating the complexity of early childhood educators’ work. Seemingly entrenched workforce shortages threaten the objectives that governments and families seek through investment in early childhood education. Popular images of work with young children as easy and instinctual, or of teaching as only school based, mislead potential workforce entrants and erode the status of educators, leading to attrition. This project’s audit and description of exemplary educators’ work, across each level of mandated qualification, will inform strategies to sustain a high quality early childhood workforce into the future.Read moreRead less