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There is an urgent need for engineered tissue repair and replacement components for cartilage implantation in damaged joints due to a shortage of donor tissue. This project will generate smart composite biomaterials with enhanced mechanical strength and physical properties that are desirable for cartilage repair. The fabricated scaffolds will mimic the microstructure of native cartilage and are next-generation biomaterials designed to facilitate cartilage regeneration.
Bioactivated Hierarchical Hydrogels As Zonal Implants For Articular Cartilage Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$353,161.00
Summary
Cartilage is frequently damaged, but does not repair on its own, and degenerates in osteoarthritis. Unfortunately, current treatments are also not able to regenerate the structure of normal cartilage and fail to restore joint function long-term. Our project, HydroZONES, brings together expertise from 16 partners to tackle this problem and regenerate cartilage with the appropriate structure to help the millions of people worldwide suffering from cartilage problems such as osteoarthritis.
A Novel Strategy For The Treatment Of Chronic Skeletal Joint Defects
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Skeletal joint injuries often heal poorly with current treatment approaches and lead to the onset of osteoarthritis. This project will produce a synthetic graft with unique properties to mimic the complex structure of joint tissues, and high bioactivity to induce optimal healing of the joint. This graft will constitute a viable alternative for the treatment of skeletal joint defects, resulting in significant healthcare benefits and improved long-term outcomes.
Smart Hybrid Material For Cartilage Tissue Engineering
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
Tissue engineering is a promising approach to repair damaged/degenerated cartilage caused by various diseases or injuries. Because of its limited capacity for self repair cartilage becomes a constriant to normal everyday life once degenerated. This project aims to develop composite polymers for cartilage repair. The potential of this newly developed material for cartilage tissue engineering will be investigated through the material and biological characterisation techniques.
Discovery Early Career Researcher Award - Grant ID: DE120101666
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Endogenous bone regenerative technique to repair hard tissue defects in congenital craniofacial clefts. This project aims to develop an endogenous bone regenerative technique to repair the bony defects in congenital craniofacial clefts, through stimulating patients' latent self-repair mechanisms and reviving their innate capacity for regeneration. The novel technique would replace the existing and controversial surgical bone grafting method.
Assessing Bone Quality and Health: Experimental imaging, structural characterisation, and mechanical modelling of bone in 3D. Age-related bone fractures due to osteoporosis impose a significant social and economic problem on our increasingly aging population. The assessment of bone quality is important in the diagnosis of age related bone fragility and for studying the efficacy of therapeutic intervens. In this proposal a unique interdisciplinary group with expertise in bone and mineral research ....Assessing Bone Quality and Health: Experimental imaging, structural characterisation, and mechanical modelling of bone in 3D. Age-related bone fractures due to osteoporosis impose a significant social and economic problem on our increasingly aging population. The assessment of bone quality is important in the diagnosis of age related bone fragility and for studying the efficacy of therapeutic intervens. In this proposal a unique interdisciplinary group with expertise in bone and mineral research, experimental 3D imaging and the characterisation and modelling of complex materials will tackle the problem of assessing bone quality and health. The proposed research will greatly improve our assessment of the mechanical competence of bone.Read moreRead less
Special Research Initiatives - Grant ID: SR0354797
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance co ....The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance communication, bring together innovative skill sets, create linkages, generate focussed research programs and foster novel commercial opportunities. Ultimately the Initiative and Network will deliver an improved quality of life, reduced healthcare costs, and increased productivity to Australia.Read moreRead less
Growth of Bioartificial Tissue Containing an Inbuilt Blood Supply. The large and growing demand for replacement tissues and organs has spurred rapid growth in the emerging field of tissue engineering, which aims to form new tissues in the laboratory by combining living cells and synthetic scaffolds. A major challenge lies in the production of thick tissues, which require a blood supply in order to survive. Uniquely, this project aims to grow in the laboratory a vascular system based on natural ....Growth of Bioartificial Tissue Containing an Inbuilt Blood Supply. The large and growing demand for replacement tissues and organs has spurred rapid growth in the emerging field of tissue engineering, which aims to form new tissues in the laboratory by combining living cells and synthetic scaffolds. A major challenge lies in the production of thick tissues, which require a blood supply in order to survive. Uniquely, this project aims to grow in the laboratory a vascular system based on natural structures, which can then be used to support new tissue growth. Australia is well placed to reap the rewards of this work, having a track record in commercialisation of medical technologies, resulting in an improved quality of life for many Australians and substantial direct and indirect economic benefits.Read moreRead less
Effects of prosthesis design on bone remodelling and longevity of dental restorations. The project targets both the 'Promoting and Maintaining Good Health' and 'Advanced Materials' designated research priority areas. The research will underpin Australia's leading role on some emerging interdisciplinary frontiers of biomechanics, biomaterials, health sciences and biomedical software. The development of computer aided clinical plan will help optimise dental restorations for 'long-term success'. Th ....Effects of prosthesis design on bone remodelling and longevity of dental restorations. The project targets both the 'Promoting and Maintaining Good Health' and 'Advanced Materials' designated research priority areas. The research will underpin Australia's leading role on some emerging interdisciplinary frontiers of biomechanics, biomaterials, health sciences and biomedical software. The development of computer aided clinical plan will help optimise dental restorations for 'long-term success'. The benefit will be to improve the ongoing performance and longevity of dental restoration, which complies with the highly demanding national goal of 'ageing well'. The study will also provide a new means to improve the therapy effect for many young Australians' effort towards a 'healthy start to their life'.Read moreRead less
Stem cell-based interface tissue engineering. Osteoarthritis (OA) causes extreme pain, disability, and reduced quality of life and overall productivity. It is the musculoskeletal disorder with the greatest social and economic implications internationally, with 9.3% of the adult population projected to suffer from OA by 2030. A tissue engineered product capable of functional repair of ligament-cartilage-bone tissue interfaces will have significant benefits. It will improve patient activity and qu ....Stem cell-based interface tissue engineering. Osteoarthritis (OA) causes extreme pain, disability, and reduced quality of life and overall productivity. It is the musculoskeletal disorder with the greatest social and economic implications internationally, with 9.3% of the adult population projected to suffer from OA by 2030. A tissue engineered product capable of functional repair of ligament-cartilage-bone tissue interfaces will have significant benefits. It will improve patient activity and quality of life, and significantly reduce OA-associated health care costs. This proposal will train a total of 12 new generation researchers in the emergent fields of stem cell biology and tissue engineering, having important benefits for the Australian scientific and industrial communities.Read moreRead less