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Echocardiographic Predictors Of Cardiovascular Outcomes And Their Progression In Diabetes Mellitus
Funder
National Health and Medical Research Council
Funding Amount
$104,664.00
Summary
Premature cardiovascular (CV) disease is the most common cause of death in diabetes, and the risk persists even after adjustment for traditional risk factors. We aim to assess the prevalence and predictors of CV disease in type 2 diabetes (DM). Additionally we will assess the prognostic utility of potential plasma biomarkers and echocardiography, perform a 8-year outcome analysis.
The Integrated Assessment Of Cardiac Function And Synchrony, And Its Clinical Implications In Cardiac Pacing.
Funder
National Health and Medical Research Council
Funding Amount
$100,381.00
Summary
Current techniques for assessing cardiac function are limited. We seek firstly to help prove the accuracy of new techniques to assess cardiac function using novel echocardiographic (cardiac ultrasound) tools. We will then apply these tools to patients with severe heart failure who are receiving cardiac resynchronisation therapy - a new, potentially life-saving type of pacemaker - to maximise potential patient benefit. We will also use these tools to help optimise conventional pacemaker function.
Identification Of Key Enzymes Required For Efficient Post-translational Modification And Multimerisation Of Adiponectin
Funder
National Health and Medical Research Council
Funding Amount
$92,364.00
Summary
Obesity is a major national and global health issue, with 62% of adult Australians being overweight/obese, associated with a number of diseases such as type 2 diabetes and cardiovascular disease. Fat tissue secretes hormones and dysregulation of these hormones contributes to the development of obesity-associated disease. This project aims to define processes governing the secretion of one key hormone and ultimately to identify targets for the treatment of obesity-associated complications.
Pharmacological Characterisation Of Venoms From Australian Box Jellyfish
Funder
National Health and Medical Research Council
Funding Amount
$33,626.00
Summary
Australian box jellyfish are responsible for many stings in Australia every year. Years of scientific research have gone into studying how these venoms work however, their mechanism of action is still unknown. Most of these venoms cause cardiovascular effects in envenomed people. Our aim is to isolate and characterise these toxins in the venoms, this will hopefully allow us to then isolate their mechanism of action. Thus allowing for better management of accidental human envenomings.
Evaluation Of Cardiac Risk And Alterations In Cardiovascular Structure And Function In Renal Transplantation
Funder
National Health and Medical Research Council
Funding Amount
$72,275.00
Summary
Despite recent advances in health care, cardiovascular disease remains the leading killer of patients with Renal Failure and following Renal Transplantation. Current methods for assessing Cardiovascular Risk largely rely on tests that utilise radiation and-or kidney-toxic substances. Recent advances in Magnetic Resonance Imaging may allow for more accurate and safer assessment of Cardiovascular Risk and improve our understanding of the effect of Renal Transplantation on the Cardiovascular System