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Monitoring cardiovascular risk is a major part of the clinical workload both in general practice and specialty areas, but it is an under-researched area, reflected in a general lack of evidence based guidelines. My research will evaluate how to optimise the monitoring of cardiovascular risk both before and after starting treatment. By maximising clinical benefits for patients and minimising unnecessary resource use, my research will benefit patients, clinicians and the community at large.
Understanding Ethnic Differences In The Relationships Between Cardiovascular Risk Factors And Cardiovascular Disease In High Risk Populations
Funder
National Health and Medical Research Council
Funding Amount
$151,374.00
Summary
Cardiovascular disease (disease of the heart and blood vessels) is the leading cause of death world-wide. However, the burden of this disease is significantly greater in some populations, including Indigenous Australians and South Asians (Indians, Pakistanis or Bangladeshis). This project therefore aims to improve our understanding of CVD risk in these populations, and to develop better clinical assessment tools that will assist in the early detection and management of CVD in these individuals.
Central Mechanisms Underlying Obesity Related Hypertension.
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
The prevalence of obesity and related disease are rising rapidly worldwide. Adult risk factors, genetic predisposition and socioeconomic factors all contribute to obesity and obesity related hypertension however there is compelling evidence that the early life environment also contributes to disease progression. In this regard, an understanding of how increased sympathetic activity occurs in programmed hypertension is required in order to develop effective therapeutic strategies.
Societal Determinants Of Cardiovascular Risk Factors And Disease In Communities In Low, Middle And High Income Countries
Funder
National Health and Medical Research Council
Funding Amount
$377,845.00
Summary
The type of neighbourhood- society we live in is increasingly recognised as importantly influencing our behaviour such as our physical activity or nutrition and therefore our health, but no comprehensive measure of societal profile exists. This research aims to devise and test a comprehensive community-profiling tool to measure these factors. This will enable communities to measure their local environment for factors that increase the risk of developing cardiovascular risk factors and disease.
A Lipidomics Approach In The Prediction Of Unstable Coronary Artery Disease
Funder
National Health and Medical Research Council
Funding Amount
$302,383.00
Summary
Despite our best efforts at lowering the ñbadî LDL-cholesterol with statins, heart disease remains the leading cause of death in Australia. One of the biggest problems is early detection of the disease. We know that people with heart disease have abnormal lipid levels. From a single blood sample, we aim to develop and optimize our lipid profiling techniques so that we can provide a cheaper but faster and more accurate test to determine those individuals who may be at much higher risk of a heart ....Despite our best efforts at lowering the ñbadî LDL-cholesterol with statins, heart disease remains the leading cause of death in Australia. One of the biggest problems is early detection of the disease. We know that people with heart disease have abnormal lipid levels. From a single blood sample, we aim to develop and optimize our lipid profiling techniques so that we can provide a cheaper but faster and more accurate test to determine those individuals who may be at much higher risk of a heart attack or stroke.Read moreRead less
Investigating The Genetic Correlation Underlying The Developmental Origins Of Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
The prevalence of cardiovascular disease and diabetes is increasing and the financial burden on society is substantial. Research has shown a link between birth weight and increased risk of these diseases. Genetics may be involved as not all individuals born of suboptimal weight go on to develop disease. This research will identify genes that jointly affect birth weight and future risk of adult disease, leading to a better understanding of the biological relationship between the two.
Improving Health Outcomes For Aboriginal And Torres Strait Islander Australians With Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$383,684.00
Summary
Based in Darwin, Dr Hughes’ research focuses on improving the health and wellbeing of Aboriginal and Torres Strait Islander peoples at risk of chronic kidney disease (CKD), and those with established Chronic and end-stage kidney disease. These studies focus on participants based in both community and hospital based populations. New areas of clinical research will be addressed, as well as health systems strengthening in both primary and tertiary care systems.