Developmental Origins Of Adult Cardiovascular Disease: Vascular Health In The Raine Cohort
Funder
National Health and Medical Research Council
Funding Amount
$1,087,427.00
Summary
The Raine study is a unique long term experiment that has collected extensive pre-birth and childhood data in ~3000 young Australians, who are now 27 years old. We plan to measure the artery health of 1200 of these volunteers and to determine what factors, both before and after birth, influence the presence of early atherosclerosis in humans. This study will guide strategies aimed at early prevention of heart attacks and stroke in humans, by defining the major risk factors.
Obesity, Pre-diabetes And Future Risk Of Diabetes: Maximising The Evidence, Minimising The Cost
Funder
National Health and Medical Research Council
Funding Amount
$470,136.00
Summary
The overarching aim of this proposal is to reliably determine how best to identify people at high risk of developing future diabetes. We will do this by using information on biological and behavioural risk factors that was collected on nearly 200,000 people many years ago and who were subsequently followed up to see who developed diabetes. This information will be used to create a risk prediction tool for spotting individuals most at risk of developing diabetes at some point in the future.
Cardiovascular disease is the biggest killer in Australia. It describes diseases of the heart and blood vessels including heart attack and stroke. The risk of developing these diseases is affected by our diet and lifestyle and also by our genetic makeup that we inherit. In this project we are aiming to identify the specific heritable genetic differences between individuals that put us at greater risk of cardiovascular disease. We are studying large families from the Busselton Health Study.
POISE-2: A Large, International, Placebo-controlled, Factorial Trial To Assess The Impact Of Clonidine And Aspirin In Patients Undergoing Noncardiac Surgery Who Are At Risk Of A Perioperative Cardiovascular Event
Funder
National Health and Medical Research Council
Funding Amount
$1,197,914.00
Summary
At least 5 million patients annually worldwide suffer a heart attack or die after noncardiac surgery. Despite the magnitude of this problem, there are no good treatments to prevent these complications. Previous studies suggest that the drugs clonidine and aspirin may minimize the risk of heart attack after surgery. The POISE-2 trial will study 10,000 patients having noncardiac surgery to determine if clonidine and aspirin improve outcomes. This trial will influence the treatment of patients havi ....At least 5 million patients annually worldwide suffer a heart attack or die after noncardiac surgery. Despite the magnitude of this problem, there are no good treatments to prevent these complications. Previous studies suggest that the drugs clonidine and aspirin may minimize the risk of heart attack after surgery. The POISE-2 trial will study 10,000 patients having noncardiac surgery to determine if clonidine and aspirin improve outcomes. This trial will influence the treatment of patients having surgery around the world.Read moreRead less
FIELD LIFE: Lifestyle Interactions In Fenofibrate And The Epigenome
Funder
National Health and Medical Research Council
Funding Amount
$1,071,754.00
Summary
Genetic and environmental factors influence the risks of developing the blood vessel (vascular), eye and kidney complications of diabetes, but how extensively these factors interact is less well understood. We will examine blood levels of a new class of regulatory molecules (called microRNAs), and of DNA damage and identify how they are linked to vascular risk factors, and heart, foot, eye and kidney damage in 2000 well-characterised Australians with type 2 diabetes from the FIELD Study.
Genetic And Early Life Predictors Of Ectopic Fat And Their Association With Cardiometabolic Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,706,136.00
Summary
Obesity in childhood predicts adult cardiovascular disease. Body mass index as a measure of obesity does not fully describe the biology of excess adiposity. However, differences in the distribution of body fat, particularly fat around organs, may explain some of the excess risk. We will examine effects of genetic, pregnancy and childhood factors on different body fats and cardiovascular risk in Raine Study participants at 26 years. These young adults have been studied from pregnancy to adulthood
The Role Of The Clotting Cascade In Aortic Aneurysm And Associated Cardiovascular Events
Funder
National Health and Medical Research Council
Funding Amount
$651,173.00
Summary
Weakening of the main abdominal artery is responsible for approximately 1000 deaths/ year in Australia. Most weakened arteries are identified at an early stage but there is no current therapy which limits the progression of artery weakening. There is also no model which predicts the complications associated with weakened arteries. In the current project we propose the importance of clot in progression and complications of weakened arteries. We will undertake studies to identify new therapies and ....Weakening of the main abdominal artery is responsible for approximately 1000 deaths/ year in Australia. Most weakened arteries are identified at an early stage but there is no current therapy which limits the progression of artery weakening. There is also no model which predicts the complications associated with weakened arteries. In the current project we propose the importance of clot in progression and complications of weakened arteries. We will undertake studies to identify new therapies and a predictive model for weakened arteries.Read moreRead less
Lipoprotein(a) Metabolism In Subjects At High Risk Of Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$690,735.00
Summary
Heart disease is a major health burden. Despite best evidence-based treatments, residual risk remains high. Lp(a), a small protein in the blood, is a powerful causal risk factor for premature heart disease, but little is known about its physiology or metabolism. This study will provide vital knowledge into Lp(a) metabolism and the mechanisms by which two unique therapies lower Lp(a) levels. These insights may expand treatment choices for people at risk of heart disease.
Obesity And Protective Properties Of High-Density Lipoproteins
Funder
National Health and Medical Research Council
Funding Amount
$391,265.00
Summary
High-density lipoproteins (HDL) are the good form of cholesterol and protect against heart disease. Obesity is associated with a high risk of heart disease and low HDL levels. The effects of obesity on the ability of HDL to prevent plaque build up in the artery wall has not been studied. This project will study how obesity affects the ability of HDL to stop plaque formation. This will provide important information linking two major health problems in Australia, obesity and heart disease.
While is important to prevent vitamin D deficiency, controversies exist about optimal vitamin D intakes and concentrations. Our aim is to evaluate safety concerns with dosages of vitamin D which are routinely promoted for unsupervised public use with over the counter products. We will do this by evaluating long-term health effects for infant vitamin D supplementation, and by using a genetic approach to evaluate the causal effects of high vitamin D and calcium concentrations.