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Special Research Initiatives - Grant ID: SR120200004
Funder
Australian Research Council
Funding Amount
$30,000,000.00
Summary
Australian Synchrotron Access Program. The Australian Synchrotron epitomises scientific research excellence in Australian and New Zealand. Its impact spans nearly every research sector. This proposal brings together over 30 Australian universities working together to ensure that world-class peer-reviewed science continues to be performed at the Australian Synchrotron.
Micro-electrofluidic platforms for monitoring 3D human biological models. The ability to study living cells and human biological models (cell cultures) delivers greater understanding of basic biological function and response to applied (bio)chemical stimuli. Creating the physical environments to sustain biological models, and mimic natural conditions and fluidic pathways, is immensely challenging, yet essential to deliver meaningful observational data. This project will deliver this capability t ....Micro-electrofluidic platforms for monitoring 3D human biological models. The ability to study living cells and human biological models (cell cultures) delivers greater understanding of basic biological function and response to applied (bio)chemical stimuli. Creating the physical environments to sustain biological models, and mimic natural conditions and fluidic pathways, is immensely challenging, yet essential to deliver meaningful observational data. This project will deliver this capability through the convergence of expertise and innovation in analytical chemistry, materials science and cellular biology, ultilising the latest technology and understanding of 3D micro/electrofluidics, to enable the study and stimulation of advanced biological models, sustained within precisely controlled 3D micro-environments.Read moreRead less
ARC Centre of Excellence for Electromaterials Science. The ARC Centre of Excellence for Electromaterials Science (ACES) will create next generation electrochemical devices via the precision assembly of nano/micro dimensional components into macroscopic structures. Through the discovery of new materials and structures, and understanding how spatial arrangement in 3D influences chemical, physical and biological properties, ACES will define the cutting edge of Electromaterials Science. The resultin ....ARC Centre of Excellence for Electromaterials Science. The ARC Centre of Excellence for Electromaterials Science (ACES) will create next generation electrochemical devices via the precision assembly of nano/micro dimensional components into macroscopic structures. Through the discovery of new materials and structures, and understanding how spatial arrangement in 3D influences chemical, physical and biological properties, ACES will define the cutting edge of Electromaterials Science. The resulting technology breakthroughs will have a direct impact on some of today's most challenging global problems in clean energy, synthetic biosystems, diagnostics and soft robotics. National benefit to Australia will be realised through the creation of new manufacturing industries.Read moreRead less
Understanding the mechanisms underpinning complex sociality. This project aims to investigate the mechanisms underlying the formation of complex social systems in vertebrates. Our understanding of these mechanisms is strongly biased towards a few model systems. We have identified a novel Australian model system with a wide range of sociality for this purpose. This project expects to generate new knowledge on how the social environment interacts with the brain during social organisation. Expected ....Understanding the mechanisms underpinning complex sociality. This project aims to investigate the mechanisms underlying the formation of complex social systems in vertebrates. Our understanding of these mechanisms is strongly biased towards a few model systems. We have identified a novel Australian model system with a wide range of sociality for this purpose. This project expects to generate new knowledge on how the social environment interacts with the brain during social organisation. Expected outcomes include the refinement of social theory and capacity building via international collaboration and postgraduate training. This work will provide significant benefits by increasing our understanding of how the brain and social environment interact to moderate aggression and enhance social associations.Read moreRead less
An efficient approach to the computation of bacterial evolutionary distance. This project aims to apply advanced mathematical tools to improve our understanding of bacterial evolution. Bacteria account for as much total Earth biomass as all plant species put together, and have an unparalleled ability to evolve quickly and adapt to changing environments. Unfortunately, the existing mathematical models used to model bacterial evolution are generally computationally intractable. This project will r ....An efficient approach to the computation of bacterial evolutionary distance. This project aims to apply advanced mathematical tools to improve our understanding of bacterial evolution. Bacteria account for as much total Earth biomass as all plant species put together, and have an unparalleled ability to evolve quickly and adapt to changing environments. Unfortunately, the existing mathematical models used to model bacterial evolution are generally computationally intractable. This project will rectify this situation by using representation theory to transform combinatorial group theory into linear algebra, allowing for the application of advanced methods of numeric approximation. This will provide a better understanding of how bacteria evolve and improve our ability to manage their impact.Read moreRead less
Lags and legacies: antecedent effects on grassland biomass response to carbon dioxide. This project aims to assess how past conditions influence grassland responses to the rising atmospheric concentration of carbon dioxide. High CO2 concentrations should stimulate productivity but in grasslands this is rarely realised because other, mostly unknown, factors constrain the response. By synthesising data from past experiments, this project aims to determine exactly why grasslands fail to realise the ....Lags and legacies: antecedent effects on grassland biomass response to carbon dioxide. This project aims to assess how past conditions influence grassland responses to the rising atmospheric concentration of carbon dioxide. High CO2 concentrations should stimulate productivity but in grasslands this is rarely realised because other, mostly unknown, factors constrain the response. By synthesising data from past experiments, this project aims to determine exactly why grasslands fail to realise the full productivity benefits of increased CO2 and when this will happen. This should improve predictions of carbon exchange and indicating the best direction for climate change adaptation measures.Read moreRead less
Changes in the ocean's biological pump: innovative models and diagnostics. This Project aims to quantify how the ocean’s biological pump, which exports newly formed organic matter into the ocean interior, responds to environmental change. The biological pump is a key control on the global carbon and oxygen cycles, and hence on the viability of marine life. New, efficient numerical models will be developed and analysed with highly innovative mathematical methods. Expected outcomes are optimised .... Changes in the ocean's biological pump: innovative models and diagnostics. This Project aims to quantify how the ocean’s biological pump, which exports newly formed organic matter into the ocean interior, responds to environmental change. The biological pump is a key control on the global carbon and oxygen cycles, and hence on the viability of marine life. New, efficient numerical models will be developed and analysed with highly innovative mathematical methods. Expected outcomes are optimised predictive models and a new understanding of the possible future evolutions of the ocean carbon cycle, acidification, and oxygenation. This should provide significant benefits such as predictions of future ocean health, identification of processes that are sensitive to change, and strategies for marine resource management.Read moreRead less
Eruption and disruption: how Earth’s deep interior and surface communicate. Massive volcanic eruptions are a fundamental part of the Earth System, responsible for globally disruptive events, from airspace disturbance, to extinction of the dinosaurs. This project will reveal relationships between hot, deep sources of volcanic material, and the tectonic processes at the Earth's surface. Expected outcomes of this project include assembling an unprecedented set of new observations from underwater vo ....Eruption and disruption: how Earth’s deep interior and surface communicate. Massive volcanic eruptions are a fundamental part of the Earth System, responsible for globally disruptive events, from airspace disturbance, to extinction of the dinosaurs. This project will reveal relationships between hot, deep sources of volcanic material, and the tectonic processes at the Earth's surface. Expected outcomes of this project include assembling an unprecedented set of new observations from underwater volcanoes offshore Eastern Australia, and the development of innovative geodynamic models of how the deep Earth interacts with the surface to form these volcanoes. This will provide significant benefits by advancing our understanding of the deep Earth, and its impact on Earth’s surface, natural hazards, and mineral systems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100043
Funder
Australian Research Council
Funding Amount
$389,000.00
Summary
Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies. This project aims to undertake fast probe-free biochemical/chemical imaging of heterogeneity within cells and materials surfaces with new infrared and Raman imaging. It will generate new fundamental knowledge on: cell heterogeneity and dynamic processes; technologies for optimising cell printing; understanding toxicity of microplastics; and protocols for measuring materials of technological relevance. Expected outcomes inc ....Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies. This project aims to undertake fast probe-free biochemical/chemical imaging of heterogeneity within cells and materials surfaces with new infrared and Raman imaging. It will generate new fundamental knowledge on: cell heterogeneity and dynamic processes; technologies for optimising cell printing; understanding toxicity of microplastics; and protocols for measuring materials of technological relevance. Expected outcomes include: interdisciplinary collaborations in new protocols for in-vitro drug development; cell printing technologies; environmental impacts of microplastics; and materials design. Expected benefits include innovative approaches to early stage drug design; improved environmental controls and advances in innovative materials.Read moreRead less
ARC Centre of Excellence for Plant Success in Nature and Agriculture. The ARC CoE for Plant Success in Nature and Agriculture will discover the adaptive strategies underpinning productivity and resilience in diverse plants and deepen knowledge of the genetic and physiological networks driving key traits. Using novel quantitative and computational approaches, the Centre will link gene networks with traits across biological levels, giving breeders an unparalleled predictive capacity. The Centre wi ....ARC Centre of Excellence for Plant Success in Nature and Agriculture. The ARC CoE for Plant Success in Nature and Agriculture will discover the adaptive strategies underpinning productivity and resilience in diverse plants and deepen knowledge of the genetic and physiological networks driving key traits. Using novel quantitative and computational approaches, the Centre will link gene networks with traits across biological levels, giving breeders an unparalleled predictive capacity. The Centre will accelerate technologies to transfer successful networks into crops and build legal frameworks to secure this knowledge. With a uniquely multidisciplinary team, the Centre will deliver new strategies to address the problems of food security and climate change, establishing Australia as a global leader in these areas.Read moreRead less