Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668435
Funder
Australian Research Council
Funding Amount
$1,300,000.00
Summary
Biomedical Engineering Sensing and Imaging Facility. The sensing and imaging facility will be the only national facility for leading engineering and medical researchers to undertake multidiscipline research into live and model biological systems. The facility will capture and combine existing strengths in these fields in Melbourne. This will provide new insights into the physiology of human, animal and plant systems and the development of preventive and curative strategies for disease.
Scaling of structure, function and energetics of the vertebrate cardiovascular system. The hearts of mammals, reptiles and fish do different amounts of work, depending on the animal’s metabolic rate and body size. This project attempts to understand why hearts are the size and thickness that they are, and whether this results in minimising the work necessary to satisfy the requirements of the animal.
Understanding And Overcoming Cardiovascular And Diabetes Inequalities In Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
Aboriginal and Torres Strait Islanders experience the highest rates of heart disease and diabetes of all Australians. The reasons for this large disparity is not yet fully understood. I propose to investigate the patterns, causes, complications and links between heart disease and diabetes in Indigenous populations to identify better ways of managing and preventing chronic disease in high risk communities.
What is the function of gamma-aminobutyric acid-gated anion channels in plants? The project will identify the molecular basis of gamma-aminobutyric acid (GABA) signalling in plants. This is significant because GABA regulates proteins that release molecules involved in root-soil interactions, growth, and fertilisation. The project's discoveries will allow improvement of these agronomic traits that ultimately determine crop yield.
A signalling pathway for future crop improvement. This project aims to decipher a mechanism that controls plant gas exchange – the process that emits oxygen, loses water, absorbs carbon dioxide and is essential for plant growth for food, fibre and fuel production. When plants encounter stressful conditions such as drought, high temperatures or flooding, they adapt their physiology to maintain viability and re-establish growth. This project will manipulate stress-induced gamma-aminobutyric acid’s ....A signalling pathway for future crop improvement. This project aims to decipher a mechanism that controls plant gas exchange – the process that emits oxygen, loses water, absorbs carbon dioxide and is essential for plant growth for food, fibre and fuel production. When plants encounter stressful conditions such as drought, high temperatures or flooding, they adapt their physiology to maintain viability and re-establish growth. This project will manipulate stress-induced gamma-aminobutyric acid’s capacity to control plant gas exchange to help secure future food production, through improving crop tolerance to stresses such as low water availability and high temperatures – conditions associated with a changing Australian climate.Read moreRead less
Improving Delivery Of Secondary Prophylaxis For Rheumatic Heart Disease: A Stepped-wedge, Community-randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,913,074.00
Summary
Rheumatic heart disease (RHD) is a major health problem in Indigenous communities. Continued progress in controlling RHD requires an understanding of how to improve delivery of regular injections of penicillin - secondary prophylaxis (SP). We will evaluate a systems-based approach to improving delivery of SP, using a stepped-wedge trial in 12 communities in NT and Qld. If successful, this model will provide a practical and transferable model.
Dissecting chloride transport in plants to secure an untapped source for improving plant productivity. Chloride and nitrate are central to physiological processes that determine crop yield and food production, but their uptake and transport within the plant body are antagonistic. This project will gain a fundamental understanding of the mechanisms underlying this antagonism. This will provide new tools for improving salinity tolerance and the efficiency of fertiliser use, which can be used for t ....Dissecting chloride transport in plants to secure an untapped source for improving plant productivity. Chloride and nitrate are central to physiological processes that determine crop yield and food production, but their uptake and transport within the plant body are antagonistic. This project will gain a fundamental understanding of the mechanisms underlying this antagonism. This will provide new tools for improving salinity tolerance and the efficiency of fertiliser use, which can be used for the development of new crop varieties. Improving these traits will be essential if we are to successfully address the threats to Australian and global food security posed by salinity, and the rising economic and environmental costs of inefficient fertiliser use.Read moreRead less
Special Research Initiatives - Grant ID: SR0354622
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network ....Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network is unique, timely and strategic in that it will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561161
Funder
Australian Research Council
Funding Amount
$110,000.00
Summary
Joint Facility for Genome Analysis of Nutrient Transport Proteins. The joint facility for genome analysis of nutrient transport proteins is a new initiative between the University of Adelaide, the Australian Centre for Plant Functional Genomics, and the University of Western Australia to use a high throughput Xenopus oocyte expression system to screen plant cDNA/cRNA collections for genes encoding nutrient transport proteins. The facility will also provide a platform to rapidly accelerate our p ....Joint Facility for Genome Analysis of Nutrient Transport Proteins. The joint facility for genome analysis of nutrient transport proteins is a new initiative between the University of Adelaide, the Australian Centre for Plant Functional Genomics, and the University of Western Australia to use a high throughput Xenopus oocyte expression system to screen plant cDNA/cRNA collections for genes encoding nutrient transport proteins. The facility will also provide a platform to rapidly accelerate our present capacity for Xenopus oocyte expression analysis of nutrient transport proteins. This facility will greatly aid our current research quantum in this field and allow for new discoveries related to nutrient transport in plants.Read moreRead less