Discovery Early Career Researcher Award - Grant ID: DE120102556
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The influence of crosstalk between protein post-translational modifications on the propagation of molecular signals. The ability of a cell to respond appropriately to its surroundings is a result of interactions between proteins and chemical modifiers termed post-translational modifications (PTM). This project will show how PTM interactions (competition/ cooperation) influence cellular outcomes in response to changes in the environment.
Discovery Early Career Researcher Award - Grant ID: DE120102451
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Spatial control of nanoporous materials for microfabrication. Treatment of numerous medical conditions will be revolutionised by biomedical devices that can deliver or remove selected molecules in precise locations (for example oxygenation of tissues, release of antitumor agents, toxin neutralisation). New lithographic protocols will be developed to enable the use of nanoporous filters directly for such purposes.
Blood pressure control by neural activation: underlying mechanisms of electric field stimulation and photostimulation of genetically targeted neurones. This project aims to understand how nerve stimulation can be used to treat drug-resistant high blood pressure. The project will lead to new benchmarks for interfacing novel technology with the nervous system and to development and enhancement of commercial devices similar to a cardiac pacemaker for patients with limited treatment options and poor ....Blood pressure control by neural activation: underlying mechanisms of electric field stimulation and photostimulation of genetically targeted neurones. This project aims to understand how nerve stimulation can be used to treat drug-resistant high blood pressure. The project will lead to new benchmarks for interfacing novel technology with the nervous system and to development and enhancement of commercial devices similar to a cardiac pacemaker for patients with limited treatment options and poor prognosis.Read moreRead less
Optimising the spring in your step to enhance footwear design. This project aims to examine how the nervous system adjusts the mechanical function of our feet across a spectrum of speeds, from slow running through to maximal effort sprinting. The proposed research will explore how the nervous system controls the function of the foot to meet the ever-varying demands of locomotion in the real-world. Expected outcomes of this project are to determine if running shoes help or hinder the natural spri ....Optimising the spring in your step to enhance footwear design. This project aims to examine how the nervous system adjusts the mechanical function of our feet across a spectrum of speeds, from slow running through to maximal effort sprinting. The proposed research will explore how the nervous system controls the function of the foot to meet the ever-varying demands of locomotion in the real-world. Expected outcomes of this project are to determine if running shoes help or hinder the natural spring-like function of the foot. It will explain a conceptually novel design allowing shoes to support our feet, whilst harnessing the energetic benefits of the foot's spring-like function. This research has the potential to revolutionise athletic footwear design and has direct implications for enhanced performance in running athletes.Read moreRead less
Understanding evolution in natural systems using robotic models. This project aims to build biologically-inspired robotic and computational systems, and then modify these in ways which are either not possible, or have not yet occurred in natural systems. A comparison of these two systems will then allow a quantitative understanding of how well optimised biological structures are and where the limitations to optimisation lie. Expected outcomes include advancing the understanding of evolutionary p ....Understanding evolution in natural systems using robotic models. This project aims to build biologically-inspired robotic and computational systems, and then modify these in ways which are either not possible, or have not yet occurred in natural systems. A comparison of these two systems will then allow a quantitative understanding of how well optimised biological structures are and where the limitations to optimisation lie. Expected outcomes include advancing the understanding of evolutionary processes, and will provide significant benefits, such as aiding the manufacture of efficient autonomous robots.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100549
Funder
Australian Research Council
Funding Amount
$373,220.00
Summary
Stratiform Optical Barcoding System for Cardiac Biomarkers: Towards Smart Computerised Clinical Prognosis of Cardiovascular Disease. This project involves the development of an innovative optical biosensing system combined with a sophisticated barcode system containing information for clinical diagnosis of cardiovascular disease. For the first time, this system will provide information on the amount and chemical structure of cardiac biomarkers at the same time by combining reflectometric interfe ....Stratiform Optical Barcoding System for Cardiac Biomarkers: Towards Smart Computerised Clinical Prognosis of Cardiovascular Disease. This project involves the development of an innovative optical biosensing system combined with a sophisticated barcode system containing information for clinical diagnosis of cardiovascular disease. For the first time, this system will provide information on the amount and chemical structure of cardiac biomarkers at the same time by combining reflectometric interference and low resolution Raman spectroscopies. These optical signals will be converted into barcodes containing several levels of information, which will be at the base of this versatile point-of-care test. The obtained results will be implemented in a computerised database to improve current cardiac disease diagnosis.Read moreRead less
The combined use of proteomics and small molecules for target identification and pathway analysis. This project intends to investigate how a series of new small molecules identified from our research to improve the metabolic effects of insulin. This project will integrate medicinal chemistry with proteomics and metabolic biology to identify the cellular targets and their mechanism of action.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100181
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Strengthening merit-based access and support at the new National Computing Infrastructure petascale supercomputing facility. World-leading high-performance computing is fundamental to Australia's international research success. This facility will provide access to the new National Computational Infrastructure facility by world-leading researchers from six research universities, and sustain ground-breaking work in an increasingly competitive environment.