InterLACE: International Collaboration For A Life Course Approach To Reproductive Health And Chronic Disease Events
Funder
National Health and Medical Research Council
Funding Amount
$495,965.00
Summary
Cardiovascular disease and diabetes are major chronic diseases among women. This world-leading research combines data from 7 international and 3 Australian studies of womenÍs health. We will investigate the relationship of reproductive health, from menarche to menopause, with the risk of Type 2 diabetes and cardiovascular disease in later life. Findings will support the development of policies and preventive health strategies to reduce the risk of these chronic diseases.
Development Of A Preventive Strategy For Rheumatic Heart Disease Using An Experimental Model
Funder
National Health and Medical Research Council
Funding Amount
$370,846.00
Summary
Based on animal studies, we aim to demonstrate that the worsening of heart damage seen in patients with rheumatic heart disease (RHD) is due to repeated infections with bacteria (group A streptococci: GAS). The heart damage is caused by continual immune damage to the heart and valves and this has adverse effects on heart function. We will also investigate a novel way to prevent the development of RHD.
A Population-based Birth Cohort Study Of The Development Of Atherosclerosis In Early Life
Funder
National Health and Medical Research Council
Funding Amount
$780,067.00
Summary
Cardiovascular disease (heart attack and stroke) are leading causes of death and illness in adults in Australia. The changes in blood vessels that lead to these conditions begin before birth. This project investigates the factors that contribute to these early changes from birth onwards, and will facilitate development of targeted prevention in high-risk groups to reduce cardiovascular disease in later life.
Developmental Origins Of Adult Cardiovascular Disease: Vascular Health In The Raine Cohort
Funder
National Health and Medical Research Council
Funding Amount
$1,087,427.00
Summary
The Raine study is a unique long term experiment that has collected extensive pre-birth and childhood data in ~3000 young Australians, who are now 27 years old. We plan to measure the artery health of 1200 of these volunteers and to determine what factors, both before and after birth, influence the presence of early atherosclerosis in humans. This study will guide strategies aimed at early prevention of heart attacks and stroke in humans, by defining the major risk factors.
The study will look at the effects of air pollution on conditions related to the heart and respiratory systems in 12,000 men enrolled in the Health in Men study in 1996-1998. We will estimate exposure to air pollution at different points in time by modelling the dispersion of pollutants around Perth. We will use data from air monitoring stations for the relevant time period. We will then look at the relationship between air pollution and health effects between 1998 and 2010.
Assessing Infrastructure And Contextual Factors In Relation To Cardiometabolic Outcomes In Remote Indigenous Communities: Evidence For Policy Change
Funder
National Health and Medical Research Council
Funding Amount
$1,113,005.00
Summary
Cardiometabolic diseases account for the major burden of morbidity and mortality for Indigenous populations. This study with 75 remote Indigenous communities will be the first to evaluate features of their social, built and physical environments in relation to cardiometabolic risks and diseases. Policy-relevant results will identify features of environments to be targeted to reduce chronic diseases for Indigenous peoples in remote communities.
Obesity, Pre-diabetes And Future Risk Of Diabetes: Maximising The Evidence, Minimising The Cost
Funder
National Health and Medical Research Council
Funding Amount
$470,136.00
Summary
The overarching aim of this proposal is to reliably determine how best to identify people at high risk of developing future diabetes. We will do this by using information on biological and behavioural risk factors that was collected on nearly 200,000 people many years ago and who were subsequently followed up to see who developed diabetes. This information will be used to create a risk prediction tool for spotting individuals most at risk of developing diabetes at some point in the future.
The Beta-blocker To LOwer CArdiovascular Dialysis Events (BLOCADE) Feasibility Study
Funder
National Health and Medical Research Council
Funding Amount
$597,811.00
Summary
The BLOCADE Feasibility Study aims to find out what is needed for a study to see if the drug carvedilol reduces heart disease events in people who need kidney dialysis. Carvedilol is widely used to treat the types of heart disease that are common in people on dialysis but the nature of dialysis may lead to more side effects or to less benefit. A Feasibility Study must be done first to properly plan a large study of carvedilol in people on dialysis that answers this important question.
Insulin Regulated Aminopeptidase: A New Cardiovascular Target
Funder
National Health and Medical Research Council
Funding Amount
$672,650.00
Summary
Cardiovascular disease, leading to heart attack or stroke is the largest cause of death in Australia. We have evidence that inhibition of a newly described enzyme (IRAP) by angiotensin IV is protective in a model of atherosclerosis. Excitingly we have preliminary data indicating that mice deficient in IRAP have better vascular function therefore we will further investigate this as well as the effectiveness of newly developed IRAP inhibitors in preventing development of cardiovascular disease.
POISE-2: A Large, International, Placebo-controlled, Factorial Trial To Assess The Impact Of Clonidine And Aspirin In Patients Undergoing Noncardiac Surgery Who Are At Risk Of A Perioperative Cardiovascular Event
Funder
National Health and Medical Research Council
Funding Amount
$1,197,914.00
Summary
At least 5 million patients annually worldwide suffer a heart attack or die after noncardiac surgery. Despite the magnitude of this problem, there are no good treatments to prevent these complications. Previous studies suggest that the drugs clonidine and aspirin may minimize the risk of heart attack after surgery. The POISE-2 trial will study 10,000 patients having noncardiac surgery to determine if clonidine and aspirin improve outcomes. This trial will influence the treatment of patients havi ....At least 5 million patients annually worldwide suffer a heart attack or die after noncardiac surgery. Despite the magnitude of this problem, there are no good treatments to prevent these complications. Previous studies suggest that the drugs clonidine and aspirin may minimize the risk of heart attack after surgery. The POISE-2 trial will study 10,000 patients having noncardiac surgery to determine if clonidine and aspirin improve outcomes. This trial will influence the treatment of patients having surgery around the world.Read moreRead less