Determining how calcium regulates mitochondrial function in models of cardiomyopathy. Heart failure is the leading cause of death in Australia. This project will determine the mechanisms by which the failing heart is associated with disorganisation of the cell and poor energy supply so that interventions aimed at reducing the development of heart failure can be developed.
Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease le ....Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease leading to the potential identification of new drug and vaccine targets. The methodologies and expertise developed will be used will be available to other research groups working on infectious diseases.Read moreRead less
From causative genes to establishing therapies for patients with neuromuscular diseases. A major focus of this project will be pursuing multiple therapeutic approaches for a class of skeletal muscle diseases, which are most often severe and lethal within the first year of life. It will also hunt down the defective genes in human patients with other neuromuscular diseases and explore how these cause disease.
Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precociou ....Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precocious puberty. Kisspeptin and RF-related peptide may offer more physiological alternatives to GnRH, without detrimental side effects. We will fully explore these two newly defined and major players in reproduction and provide a physiological framework for their progression to clinical use.Read moreRead less
The development of tools to study carbohydrate-processing enzymes implicated in human disease. Diseases caused by improper function of carbohydrate-processing enzymes are a major health burden. This research aims to find ways to restore the function of these enzymes bringing a better quality of life to people suffering from these diseases.
Complex dynamical systems: inferring form and function of interacting biological systems. Often in biology a large number of simple parts interacting according to simple rules can result in behaviour that is rich and varied. This project aims to develop the mathematics of complex systems theory to describe how such collections of simple interacting parts can form large complicated structures, and to deduce what dynamical behaviour can result.
Manipulating population sex ratio to eradicate invasive mouse populations. This project aims to use house mice, an Australian pest of economic importance which is also a highly tractable system for testing evolutionary theory and generating practical outcomes. Manipulating population sex ratio is a powerful tool for either enhancing the viability of threatened species or decimating pests. However, despite much scientific effort testing sex ratio theory, the cryptic mechanisms driving sex allocat ....Manipulating population sex ratio to eradicate invasive mouse populations. This project aims to use house mice, an Australian pest of economic importance which is also a highly tractable system for testing evolutionary theory and generating practical outcomes. Manipulating population sex ratio is a powerful tool for either enhancing the viability of threatened species or decimating pests. However, despite much scientific effort testing sex ratio theory, the cryptic mechanisms driving sex allocation remain unidentified, hindering progress in these fields. The project will identify the mechanisms by which sex ratio adjustments are made and establish how individual-level responses influence insular population structure and growth. It will provide benefits by assisting Australia's efforts in eradicating invasive mouse populations.Read moreRead less
Building better Brassicas: Understanding disease resistance mechanisms across the Brassicaceae. Brassica species are important crops producing cooking oil, vegetables and biofuel, grown in diverse environments with a high economic and export value. Blackleg disease, caused by the fungus Leptospheria maculans, is the most important disease of brassica crops world-wide. The newly available brassica genome sequence provides the resources to study the co-evolution of this plant and pathogen. This pr ....Building better Brassicas: Understanding disease resistance mechanisms across the Brassicaceae. Brassica species are important crops producing cooking oil, vegetables and biofuel, grown in diverse environments with a high economic and export value. Blackleg disease, caused by the fungus Leptospheria maculans, is the most important disease of brassica crops world-wide. The newly available brassica genome sequence provides the resources to study the co-evolution of this plant and pathogen. This project will characterise the evolution and conservation of resistance genes in wild and cultivated brassicas, using next-generation sequencing technology, to assess their potential for crop improvement. An understanding of the evolution of genes responsible for resistance will lead to improved plant protection strategies for brassica crops.Read moreRead less
Threshold evolution: conceptualising decisions as traits. All organisms make decisions, yet the diversity of decision rules across the spectrum of life can be understood through a few key evolutionary models. This project will test these models and then apply them to understanding topics as diverse as pest outbreaks, human twinning, sex ratio evolution and disease spread as a consequence of climate change.
Understanding the enigma of the most energetic particles in the Universe. By combining an innovative Unmanned Aerial Vehicle (UAV)-based calibration technique with the unparalleled sensitivity of future gamma-ray and radio telescope arrays, this project will study astronomical particle accelerators and Dark Matter with unprecedented accuracy. This will afford us a unique view of the Universe' most energetic processes and allow us to study the laws of physics inaccessible to us in the lab. In the ....Understanding the enigma of the most energetic particles in the Universe. By combining an innovative Unmanned Aerial Vehicle (UAV)-based calibration technique with the unparalleled sensitivity of future gamma-ray and radio telescope arrays, this project will study astronomical particle accelerators and Dark Matter with unprecedented accuracy. This will afford us a unique view of the Universe' most energetic processes and allow us to study the laws of physics inaccessible to us in the lab. In the context of interdisciplinary research, the UAV innovation created will also be leveraged against key applications of remote sensing. With these two goals, this project will demonstrate the capabilities of novel Australian technology whilst providing Australia with a unique science use-case in high-energy astrophysics.Read moreRead less