Echocardiographic Predictors Of Cardiovascular Outcomes And Their Progression In Diabetes Mellitus
Funder
National Health and Medical Research Council
Funding Amount
$104,664.00
Summary
Premature cardiovascular (CV) disease is the most common cause of death in diabetes, and the risk persists even after adjustment for traditional risk factors. We aim to assess the prevalence and predictors of CV disease in type 2 diabetes (DM). Additionally we will assess the prognostic utility of potential plasma biomarkers and echocardiography, perform a 8-year outcome analysis.
Designing Novel Apolipoprotein A1 Mimetic Peptides As Drug Treatment For Atherosclerosis
Funder
National Health and Medical Research Council
Funding Amount
$60,016.00
Summary
Cardiovascular disease is the formation of atherosclerotic plaques caused by the imbalance between the amount of cholesterol delivered and removed from the arteries. Apolipoprotein A-1 (ApoA-1) is the main protein of high density lipoprotein (HDL) and removes cholesterol out of cell. In this project we are aimed at designing and testing new drugs (ApoA1-mimetic peptides) which will elicit the same anti-atherogenic properties as apoA-1, as a therapeutic agent for prevention of atherosclerosis.
Evaluation Of Cardiac Risk And Alterations In Cardiovascular Structure And Function In Renal Transplantation
Funder
National Health and Medical Research Council
Funding Amount
$72,275.00
Summary
Despite recent advances in health care, cardiovascular disease remains the leading killer of patients with Renal Failure and following Renal Transplantation. Current methods for assessing Cardiovascular Risk largely rely on tests that utilise radiation and-or kidney-toxic substances. Recent advances in Magnetic Resonance Imaging may allow for more accurate and safer assessment of Cardiovascular Risk and improve our understanding of the effect of Renal Transplantation on the Cardiovascular System
Regulation Of Macrophage Gene Expression And Function By Histone Deacetylases
Funder
National Health and Medical Research Council
Funding Amount
$35,909.00
Summary
Macrophages are white blood cells that play a major role in the development of inflammatory diseases such as rheumatoid arthritis and atherosclerosis, diseases that are a major burden to Australian society. This project aims to characterise the effects of a novel class of potential anti-inflammatory agents on macrophages. Defining how these drugs modify macrophages in disease models will allow design of therapeutics with minimal side effects.