ARDC Research Link Australia

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $157,848.00
Summary: The brain regulates bodily functions in a complex manner. One such example is the regulation of blood pressure and heart rate. This is achieved by an interconnected network of brain nuclei that sense information from the major blood vessels and integrate appropriate responses to maintain the status quo. Chemicals called neurotransmitters convey the nervous messages, and one such example is purines, which include ATP and adenosine. Both ATP and adenosine can act in a number of brain regions to mo ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $400,247.00
Summary: The circulatory system of the body acts in concert with the respiratory system to distribute oxygenated blood to the brain and other organs and tissues of the body. Control of blood pressure and heart rate is achieved largely through the actions of the central nervous system on effector organs and tissues such as the heart and blood vessels. This control is exerted through the actions of nerves in the body which affect the rate and force of contraction of the heart and the diameter of blood vess ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $358,770.00
Summary: The hypothalamus is a brain structure common to all mammals. Experiments on the rat have shown the hypothalamus to be fundamentally involved in cardiovascular control, fluid and electrolyte balance, food ingestion and energy metabolism, thermoregulatory and immune responses, and defensive-aggressive responses and reproduction. It is virtually impossible to perform functional studies in the human and, therefore, the human hypothalamic regions involved in these functions will be inferred from thei ....
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Funded Activity

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $347,036.00
Summary: We are seeking to develop a method to precisely determine which parts of the brain are involved in the carrying out of different brain functions. The main advantage of our new method will be that we will be able to directly visualise the circuitry involved in a specified brain function. The brain is like a vast computer, with literally billions of connections between different parts, and it is these connections which are used to form functional circuits, which ultimately result in the brain cont ....
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Funded Activity

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $209,250.00
Summary: The renin angiotensin system is one of the major homonal systems of the body that regulate the cardiovascular system and bodily salt and water balance. Drugs that inhibit the function of this system by reducing the blood level of the hormone angiotensin II or blocking the receptors at which it acts are in the forefront of treatment of high blood pressure and heart failure. It has been proposed that a separate brain renin angiotensin system exists that is not influenced by angiotensin II in the b ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $299,625.00
Summary: Brain-derived neurotrophic factor (BDNF) is an extraordinary neurotrophin which acts not only as a classical neurotrophic factor to promote neuronal survival and differentiation but also as a neuromodulator to modulate nerve activity. Recently, we found that injection of exogenous BDNF into brain stem triggers a significant increase in blood pressure. The present proposal is to test the hypothesis that BDNF is a physiological neuromodulator regulating blood pressure. The aim of this study is to ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $553,236.00
Summary: Currently there are limited therapeutic treatments and no cure for Alzheimer's disease (AD). The key protein causing AD is called Abeta. Abeta peptides form dityrosine cross-linked dimers (when 2 peptides join together) and this is thought to be responsible for killing brain cells in AD. Therefore, this proposal will determine the role of Abeta dimers in relation to killing brain cells and the progression of AD through analysis of their biological and biochemical properties.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $291,451.00
Summary: Nerves called sympathetic nerves stimulate the heart and raise blood pressure. The brain drives them when we are excited or frightened. It also over-drives them in cardiovascular diseases, and this makes matters worse. This project will use MRI brain scanning to investigate, for the first time, how the cerebral cortex and brain stem act together to control sympathetic nerves. Understanding how this system works normally will help tell us how it may malfunction, and what we can do to correct it.

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