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Development Of A Transdiagnostic Intervention For Patients With Cancer Experiencing Anxiety In The Context Of Ongoing Uncertainty
Funder
National Health and Medical Research Council
Funding Amount
$72,768.00
Summary
Surprisingly little work has been done to explain how anxiety develops and persists in patients with cancer. A model was recently developed to explain how fears of cancer recurrence develop and persist, which led to a new intervention. This study proposes to extend that work for patients with ongoing cancer threat or poor prognosis. The proposed study will develop a model of cancer-related anxiety and develop and test an intervention for anxiety in cancer patients with ongoing uncertainty.
The assessment of thrombosis requires the holistic evaluation of in-vivo coagulation including total clot formation. Unfortunately, current tests only evaluate the time to the start of clot formation. Experimental biomarkers such us thrombin generation, endothelial markers, microparticles and microRNA may provide a better framework for evaluating thrombotic risk. Translation of these markers to clinical use requires understanding of their expression in the normal population and assessment of the ....The assessment of thrombosis requires the holistic evaluation of in-vivo coagulation including total clot formation. Unfortunately, current tests only evaluate the time to the start of clot formation. Experimental biomarkers such us thrombin generation, endothelial markers, microparticles and microRNA may provide a better framework for evaluating thrombotic risk. Translation of these markers to clinical use requires understanding of their expression in the normal population and assessment of their ability to detect thrombotic disorders.Read moreRead less
Improving The Long-term Outcomes Of The Australian And New Zealand Fontan Population
Funder
National Health and Medical Research Council
Funding Amount
$89,836.00
Summary
The Fontan procedure is the last of a series of operations offered to children born with hearts with a single pumping chamber. Without this procedure these children would die, however, with this procedure their long-term expectations are still uncertain. This study will investigate the long-term outcomes of the Australian and New Zealand Fontan population and how these outcomes can be improved.
Investigation Of Regulators That Control The Pro-survival Molecule MCL1 And Its Stabililty In Lymphoma And Myeloma Cells
Funder
National Health and Medical Research Council
Funding Amount
$169,162.00
Summary
B cell malignancies are common and in many cases result in mortality. The BCL-2 family protein MCL-1 has been shown to be over-expressed in many B cell malignancies. However, the regulation and biology of MCL-1 in these cancers remains largely unknown. We aim to define mechanisms that control regulation of MCL-1 expression in cancer cells at the transcriptional and protein level and hence identify new therapeutic targets.
The Epidemiology Of Post Thrombotic Syndrome Following The Use Of Central Venous Lines In Paediatrics
Funder
National Health and Medical Research Council
Funding Amount
$130,203.00
Summary
The association between central venous lines (CVL) and blood clots in children is well known. Possible consequences of CVL-related blood clots are line blockage, pulmonary embolism (blood clots in the lungs) and post-thrombotic syndrome (PTS). PTS symptoms can be physically limiting, painful and disfiguring. Yet as the incidence of PTS is unknown, the importance of treating CVL-related blood clots is unclear. This study will assess the incidence of PTS and the associated risk factors in children ....The association between central venous lines (CVL) and blood clots in children is well known. Possible consequences of CVL-related blood clots are line blockage, pulmonary embolism (blood clots in the lungs) and post-thrombotic syndrome (PTS). PTS symptoms can be physically limiting, painful and disfiguring. Yet as the incidence of PTS is unknown, the importance of treating CVL-related blood clots is unclear. This study will assess the incidence of PTS and the associated risk factors in children.Read moreRead less
Dual 68-Gallium/FDG PET Imaging In Neuroendocrine Tumours
Funder
National Health and Medical Research Council
Funding Amount
$75,006.00
Summary
Neuroendocrine tumours (NETs) are uncommon cancers. Low-grade tumours may grow very slowly and not require treatment, but high-grade tumours can grow over weeks and have a poor prognosis. Grade is determined by looking at tissue, but this may vary considerably even in different disease sites in the same patient. Two PET scans (FDG PET and 68Gallium PET) can show high grade and low grade disease respectively, and we plan to investigate their combination in imaging advanced neuroendocrine tumours.
Management Of Paediatric Acute Severe Behavioural Disturbance In The Emergency Department
Funder
National Health and Medical Research Council
Funding Amount
$114,376.00
Summary
Acute Severe Behavioural Disturbance (ASBD) is a medical condition where a person loses control of their behaviour and becomes extremely agitated or aggressive. It usually occurs as a result of an underlying medical problem. People who develop ASBD often come to the Emergency Department (ED) to receive care. My PhD will investigate why children develop ASBD and determine the best management for these individuals when they present to the ED.
20% Human Albumin Solution FLuid Bolus AdministratIon TheRapy In Patients After Cardiac Surgery-II (HAS FLAIR-II)
Funder
National Health and Medical Research Council
Funding Amount
$125,396.00
Summary
Patients undergoing cardiac surgery often need a fluid bolus which is a volume of fluid given over a short period of time to improve their circulation. This intervention is essential as poor circulation may cause damage to important organs in the body such as the heart, lungs and kidneys. This study will allow doctors to make informed decisions about which type of fluid is better for their patients having cardiac surgery in the future.
Out-of-hospital cardiac arrest is fatal without immediate resuscitation. Paramedic competency in resuscitation has been shown to influence cardiac arrest survival. Through my doctoral research I aim to investigate: how paramedic exposure to cardiac arrest can influence patient survival; the practices emergency medical services currently use to develop and maintain paramedic competency in resuscitation; and the confidence and perceived competency of paramedics responding to cardiac arrests.
A Prospective Investigation Of Musculoskeletal And Vestibular Deficits Post-concussion In Adolescent Rugby Players
Funder
National Health and Medical Research Council
Funding Amount
$66,746.00
Summary
The primary aim of this thesis will be to investigate deficits in the musculoskeletal and vestibular systems in the acute and subacute periods following sport-related concussion injury in school level rugby union players.