Harnessing Imaging And IT Strategies To Expedite Targeted Treatment And Improve Outcomes In Cerebrovascular Diseases
Funder
National Health and Medical Research Council
Funding Amount
$2,914,215.00
Summary
This project will expand on my 25+ years of research in combining neuroimaging methods such as CT and MRI with nascent software tools to better target and coordinate treatment and achieve improved outcomes in cerebrovascular diseases such as stroke. We will develop & improve new CT and MRI methods and leverage latest advances in computer science, such as deep learning and mobile phone app technology, to achieve faster and more accurate identification of patients who can benefit from treatment.
An Imaging-genomic Approach To Advance Understanding Of Early Cortical Development And Outcome After Preterm Birth
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
In Australia, over 26,000 babies are born too early each year, with long-lasting consequences to their development. We do not know how preterm birth affects the newborn brain. In order to improve our understanding, I will combine neuroimaging and genetic data to uncover how preterm birth affects the development of the brain in newborns and how this imparts risk for poor cognitive and motor outcomes. This will allow us better plan and monitor clinical trials and treatments for these infants.
A Network Approach To Mapping And Modifying Brain Changes In Psychosis
Funder
National Health and Medical Research Council
Funding Amount
$2,163,245.00
Summary
Psychosis fundamentally alters a person’s relationship with reality. Brain scans can map which parts of the brain are affected by psychosis, but they cannot reveal the actual disease processes that cause these changes. I will address this gap by integrating brain imaging with genetics and mathematical modelling to identify the brain circuits and molecules that impact risk for psychosis, and to develop targeted therapies that modify risk-related brain dysfunction.
Improving Outcomes In Patients With Life-threatening Ventricular Arrhythmias
Funder
National Health and Medical Research Council
Funding Amount
$606,009.00
Summary
This grant focuses on improving outcomes in patients with life-threatening ventricular arrhythmias (VAs). The AUGMENT-VA trial compares standard techniques for energy delivery during cardiac arrest with ‘manual pressure augmentation’, a novel technique which may improve energy delivery to the heart & restore normal rhythm sooner. The SUBSTRATE-VA study looks at the role of invasive mapping of the heart for unexplained VAs to identify subtle abnormalities that could be targeted for treatment.
Improving Outcomes And Cost Of Systemic Sclerosis Related Pulmonary Arterial Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
My research program aims to improve the outcomes for those living with systemic sclerosis related pulmonary arterial hypertension (SSc-PAH) and reduce its associated societal burden through the evaluation and implementation of a novel PAH screening algorithm; the use of risk stratification tools in therapeutic decisions; and the development of a more streamlined management approach. My research will initiate collaboration across multiple medical disciplines and sites nationally.